The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Safety of prothrombin complex concentrates for rapid anticoagulation reversal of vitamin K antagonists: A meta-analysis
Abstract
Summary: Prothrombin complex concentrates (PCCs) are recommended as the treatment of choice in warfarin-related coagulopathy. However, the risk of thromboembolic complications associated with their use is not well defined. We performed a meta-analysis to estimate the rate of thromboembolic complications in patients receiving vitamin K antagonists (VKAs) treated with PCCs for bleeding or before urgent surgery. Medline and Embase databases were searched. Two reviewers performed study selection and extracted data independently. Studies providing data on incidence of thromboembolic complications in VKA-treated patients were eligible for the study. Weighted mean proportion of the rate of thromboembolic complications and the mortality rate were calculated. Twenty-seven studies (1,032 patients) were included. Seven studies used 3-factor, and 20 4-factor PCCs. Twelve patients had a thromboembolic complication (weighted mean 1.4%; 95% CI 0.8–2.1), of which two were fatal. The incidence of thromboembolic events was 1.8% (95% CI 1.0–3.0) in patients treated with 4-factor PCCs, and 0.7% (95% CI 0.0–2.4) in patients treated with 3-factor PCCs. Total mortality rate was 10.6% (95% CI 5.9–16.6). In conclusion, our results suggest there is a low but quantifiable risk of thromboembolism in VKA-treated patients receiving PCCs for anticoagulation reversal. These findings should be confirmed in randomised, controlled trials.
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Cites
Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139
Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>
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“To avoid bias which is more likely in smaller studies (12), only studies including at least five patients were included.”
Pharmacology and Management of the Vitamin K Antagonists
Ansell, J., Hirsh, J., Hylek, E., Jacobson, A., Crowther, M., & Palareti, G. (2008) · Chest · doi:10.1378/chest.08-0670 · Cited by 2,118
Self-citationEfficacy and Safety of Recombinant Activated Factor VII for Acute Intracerebral Hemorrhage
Mayer, S. A., Brun, N. C., Begtrup, K., Broderick, J., Davis, S., Diringer, M. N., Skolnick, B. E., & Steiner, T. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0707534 · Cited by 1,255
Linkins, L.-A., Choi, P. T., & Douketis, J. D. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-11-200312020-00007 · Cited by 764
Safety of Recombinant Activated Factor VII in Randomized Clinical Trials
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Bleeding Complications With Warfarin Use: A Prevalent Adverse Effect Resulting in Regulatory Action
Wysowski, D. K., Nourjah, P., & Swartz, L. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.13.1414 · Cited by 547
Bleeding complications in oral anticoagulant therapy. An analysis of risk factors
van der Meer, F. J. (1993) · Archives of Internal Medicine · doi:10.1001/archinte.153.13.1557 · Cited by 538
Tips for learners of evidence-based medicine: 3. Measures of observer variability (kappa statistic)
McGinn, T. (2004) · Canadian Medical Association Journal · doi:10.1503/cmaj.1031981 · Cited by 482
Cited by
Antithrombotic Therapy for Atrial Fibrillation
Lip, G. Y. H., Banerjee, A., Boriani, G., Chiang, C. E., Fargo, R., Freedman, B., Lane, D. A., Ruff, C. T., Turakhia, M., Werring, D., et al. (2018) · Chest · doi:10.1016/j.chest.2018.07.040 · Cited by 939
Goldstein, J. N., Refaai, M. A., Milling, T. J., Lewis, B., Goldberg-Alberts, R., Hug, B. A., & Sarode, R. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61685-8 · Cited by 461
De Hert, S., Staender, S., Fritsch, G., Hinkelbein, J., Afshari, A., Bettelli, G., Bock, M., Chew, M. S., Coburn, M., De Robertis, E., et al. (2018) · European Journal of Anaesthesiology · doi:10.1097/eja.0000000000000817 · Cited by 389
Major Bleeding in Patients With Atrial Fibrillation Receiving Apixaban or Warfarin
Hylek, E. M., Held, C., Alexander, J. H., Lopes, R. D., De Caterina, R., Wojdyla, D. M., Huber, K., Jansky, P., Steg, P. G., Hanna, M., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.02.549 · Cited by 344
Self-citation
Metadata
- Authors
- Marchesi, C., Pierfranceschi, M., Crowther, M., Garcia, D., Hylek, E., Witt, D., Clark, N., Squizzato, A., Imberti, D., Ageno, W., & Dentali, F.
- Venue
- Thrombosis and Haemostasis
- Publisher
- Georg Thieme Verlag KG
- Published
- 2011
- Volume
- 106
- Issue
- 09
- Pages
- 429-438
- ISSN
- 0340-6245 (ISSN-L)
- 2567-689X
- OpenAlex
- W1922017495
- Cited by
- 306
- References
- 37
- FWCI
- 19.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Marchesi, C., Pierfranceschi, M., Crowther, M., Garcia, D., Hylek, E., Witt, D., Clark, N., Squizzato, A., Imberti, D., Ageno, W., & Dentali, F. (2011). Safety of prothrombin complex concentrates for rapid anticoagulation reversal of vitamin K antagonists: A meta-analysis. Thrombosis and Haemostasis. https://doi.org/10.1160/th11-01-0052
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