Inflammatory markers and occurrence of falls
Open accessAbstract
OBJECTIVE: Analyze whether inflammatory markers are associated with falls among older adults living in Bambuí. METHODS: Study that analyzed baseline data from a Bambuí Cohort Study of Aging, involving 1,250 participants. Data about falls were collected from previous 12 months, classified as single or multiple occurrence and severity (participant seeking health services). Information about sociodemographic characteristics, health behaviors and health condition was also collected and used as confounding factors. The exposures of interest included interleukins (IL-1β, IL-6, IL-8, IL-10, IL-12), tumor necrosis factor (TNF), ultra-sensitive C-reactive protein (us-CRP) and chemokines (CXCL9, CCL5, CCL10, MCP1). Data were processed through logistic regression, obtaining odds ratio and 95% confidence interval (95%CI). RESULTS: The prevalence of falls was 27.1%; 40.1% of the older adults reported multiple falls and 33.3% sought health services. After adjustments, the following elevated levels were associated with falls: us-CRP (OR = 1.46, 95%CI 1.04–2.03), CCL5 (OR = 1.38, 95%CI 1.01–1.90) and CXCL9 (OR = 1.43, 95%CI 1.02–2.02). An association was observed between the number of elevated markers and the occurrence of falls: two (OR = 1.47, 95%CI 1.02–2.12) and three (OR = 2.08, 95%CI 1.12–3.87) elevated biomarkers indicated fall probability of 32.0% and 39.4%, respectively. CONCLUSIONS: Elevated levels of us-CRP, CCL5 and CXCL9, which were associated with falls, may contribute to a proper understanding of the mechanism associated with the occurrence of falls among older people.
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CXCL9 is associated with falls in the older population.
“Notably, CXCL9 has also been shown to be associated with falls in the older population101,102”
From An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging (2021) · cites this paper as [101]
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- Authors
- Amorim, J. S. C. D., Torres, K. C. L., Teixeira-Carvalho, A., Martins-Filho, O. A., Lima-Costa, M. F., & Peixoto, S. V.
- Affiliations
- Fiocruz Minas (BR)
- Universidade Federal de Minas Gerais (BR)
- ORCID
- Venue
- Revista de Saúde Pública
- Published
- 2019-03-26
- Volume
- 53
- Pages
- 35
- ISSN
- 0034-8910 (ISSN-L)
- 1518-8787
- PMC
- PMC6474745
- OpenAlex
- W2928106214
- Cited by
- 16
- References
- 31
- Citations by year
- 2025: 4 · 2024: 5 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Revista de Saúde Pública (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Americanae (AECID Library) (publishedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by)
- Arca - Repositório Institucional da Fiocruz (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Topics
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- falls, older adults, inflammatory markers, C-reactive protein, RANTES, CXCL9, chemokines, interleukins, TNF-α, fall risk
- MeSH terms
- Accidental Falls, Aged, Aging, Brazil, Educational Status, Female, Humans, Interleukins, Male, Middle Aged, Nutritional Status, Prospective Studies, Risk Factors, Tumor Necrosis Factor-alpha, Biomarkers, Body Mass Index, Polymerase Chain Reaction, Chemokines
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