Vascular Inflammation and the Renin-Angiotensin System

Atherosclerosis--an inflammatory disease

Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725

Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients

(2000) · New England Journal of Medicine · doi:10.1056/nejm200001203420301 · Cited by 8,663

Acute-Phase Proteins and Other Systemic Responses to Inflammation

Gabay, C., & Kushner, I. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902113400607 · Cited by 6,734

Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction: Results of the Survival and Ventricular Enlargement Trial

Pfeffer, M. A., Braunwald, E., Moyé, L. A., Basta, L., Brown, E. J., Cuddy, T. E., Davis, B. R., Geltman, E. M., Goldman, S., Flaker, G. C., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199209033271001 · Cited by 5,911

C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women

Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850

Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men

Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504

NAD(P)H Oxidase: Role in Cardiovascular Biology and Disease

Griendling, K. K., Sorescu, D., & Ushio-Fukai, M. (2000) · Circulation Research · doi:10.1161/01.res.86.5.494 · Cited by 2,886

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

Griendling, K. K., Minieri, C. A., Ollerenshaw, J. D., & Alexander, R. W. (1994) · Circulation Research · doi:10.1161/01.res.74.6.1141 · Cited by 2,735

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

Rajagopalan, S., Kurz, S. D., Münzel, T. F., Tarpey, M. M., Freeman, B. Α., Griendling, K. K., & Harrison, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118623 · Cited by 2,467

Plasma Concentration of Interleukin-6 and the Risk of Future Myocardial Infarction Among Apparently Healthy Men

Ridker, P. M., Rifai, N., Stampfer, M. J., & Hennekens, C. H. (2000) · Circulation · doi:10.1161/01.cir.101.15.1767 · Cited by 2,429

Progenitors in motion: mechanisms of mobilization of endothelial progenitor cells

Tilling, L., Chowienczyk, P., & Clapp, B. R. (2009) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2009.03486.x · Cited by 106

Effects of Angiotensin II Receptor Blockade with Valsartan on Pro-Inflammatory Cytokines in Patients with Essential Hypertension

Manabe, S., Okura, T., Watanabe, S., Fukuoka, T., & Higaki, J. (2005) · Journal of Cardiovascular Pharmacology · doi:10.1097/01.fjc.0000185783.00391.60 · Cited by 102

Crucial role of renin-angiotensin system in the pathogenesis of atherosclerosis

Sata, M., & Fukuda, D. (2010) · The Journal of Medical Investigation · doi:10.2152/jmi.57.12 · Cited by 103

Candesartan Reduces Oxidative Stress and Inflammation in Patients with Essential Hypertension

Dohi, Y., Ohashi, M., Sugiyama, M., Takase, H., Sato, K., & Ueda, R. (2003) · Hypertension Research · doi:10.1291/hypres.26.691 · Cited by 103

Expression of ACE2, Soluble ACE2, Angiotensin I, Angiotensin II and Angiotensin-(1-7) Is Modulated in COVID-19 Patients

Osman, I. O., Melenotte, C., Brouqui, P., Million, M., Lagier, J., Parola, P., Stein, A., Scola, B. L., Meddeb, L., Mège, J., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.625732 · Cited by 103

Inflammation, arteriosclerosis, and cardiovascular therapy in hemodialysis patients

London, G. M., Marchais, S. J., Guérin, A. P., Métivier, F., Adda, H., & Pannier, B. (2003) · Kidney International · doi:10.1046/j.1523-1755.63.s84.25.x · Cited by 96

Gut microbiota and renin-angiotensin system: a complex interplay at local and systemic levels

Jaworska, K., Koper, M., & Ufnal, M. (2021) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00099.2021 · Cited by 93

Systemic lupus erythematosus and hypertension

Munguía‐Realpozo, P., Pinto, C. M., Sierra, C., Escarcega, R. O., García‐Carrasco, M., Méndez‐Martínez, S., Etchegaray‐Morales, I., Gálvez-Romero, J. L., Ruı́z-Argüelles, A., & Cervera, R. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2019.102371 · Cited by 94

Role of IL-6 in Angiotensin II–Induced Retinal Vascular Inflammation

Rojas, M., Zhang, W., Lee, D. L., Romero, M. J., Nguyen, D. T., Al‐Shabrawey, M., Tsai, N., Liou, G. I., Brands, M. W., Caldwell, R. W., et al. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-3375 · Cited by 93

p38 MAPK Inhibition Reduces Aortic Ultrasmall Superparamagnetic Iron Oxide Uptake in a Mouse Model of Atherosclerosis

Morris, J. B., Olzinski, A. R., Bernard, R. E., Aravindhan, K., Mirabile, R. C., Boyce, R. W., Willette, R. N., & Jucker, B. M. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.151175 · Cited by 91

Maternal autoantibodies from preeclamptic patients activate angiotensin receptors on human mesangial cells and induce interleukin-6 and plasminogen activator inhibitor-1 secretion

Bobst, S., Day, M.-C., GILSTRAPIII, L., XIA, Y., & Kellems, R. E. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2004.10.002 · Cited by 90

Vasculopathy and Coagulopathy Associated with SARS-CoV-2 Infection

Labò, N., Ohnuki, H., & Tosato, G. (2020) · Cells · doi:10.3390/cells9071583 · Cited by 92

Biochemical indicators of cardiac and renal function in a healthy elderly population

Johnston, N., Jernberg, T., Lindahl, B., Lindbäck, J., Stridsberg, M., Larsson, A. O., Venge, P., & Wallentin, L. C. (2003) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2003.11.002 · Cited by 89

Chemokine Receptor 2b Inhibition Provides Renal Protection in Angiotensin II–Salt Hypertension

Elmarakby, A. A., Quigley, J. E., Olearczyk, J. J., Sridhar, A., Cook, A. K., Inscho, E. W., Pollock, D. M., & Imig, J. D. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.098806 · Cited by 84

Is Oxidant Stress a Connection Between Obesity and Atherosclerosis?

Morrow, J. D. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000063107.86298.fd · Cited by 87

Angiotensin II Infusion–Induced Inflammation, Monocytic Fibroblast Precursor Infiltration, and Cardiac Fibrosis are Pressure Dependent

Qi, G., Jia, L., Li, Y., Bian, Y., Cheng, J., Li, H., Xiao, C., & Du, J. (2011) · Cardiovascular Toxicology · doi:10.1007/s12012-011-9109-z · Cited by 85

Obesity, Lutein Metabolism, and Age-Related Macular Degeneration: A Web of Connections

Johnson, E. J. (2005) · Nutrition Reviews · doi:10.1111/j.1753-4887.2005.tb00105.x · Cited by 82

Role of JAK/STAT Pathway in IL-6-Induced Activation of Vascular Smooth Muscle Cells

Watanabe, S., Mu, W., Kahn, A., Jing, N., Li, J., Lan, H. Y., Nakagawa, T., Ohashi, R., & Johnson, R. J. (2004) · American Journal of Nephrology · doi:10.1159/000079706 · Cited by 83

Essential Hypertension

Androulakis, E. S., Tousoulis, D., Παπαγεωργίου, Ν., Tsioufis, C. P., Kallikazaros, I. E., & Stefanadis, C. (2009) · Cardiology in Review · doi:10.1097/crd.0b013e3181b18e03 · Cited by 83

Irbesartan Treatment Reduces Biomarkers of Inflammatory Activity in Patients With Type 2 Diabetes and Microalbuminuria

Persson, F., Rossing, P. R., Hovind, P. H., Stehouwer, C. D. A., Schalkwijk, C. G., Tarnow, L., & Parving, H. (2006) · Diabetes · doi:10.2337/db06-0827 · Cited by 81

Acute and subchronic exposure to air particulate matter induces expression of angiotensin and bradykinin-related genes in the lungs and heart: Angiotensin-II type-I receptor as a molecular target of particulate matter exposure

Aztatzi-Aguilar, O. G., Uribe-Ramírez, M., Arias‐Montaño, J., Barbier, O. C., & Vizcaya‐Ruíz, A. D. (2015) · Particle and Fibre Toxicology · doi:10.1186/s12989-015-0094-4 · Cited by 79

Maternal obesity induces fibrosis in fetal myocardium of sheep

Huang, Y., Yan, X., Zhao, J. X., Zhu, M. J., McCormick, R. J., Ford, S. P., Nathanielsz, P. W., Ren, J. T., & Du, ‬. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00434.2010 · Cited by 79

ACE inhibition lowers angiotensin II-induced chemokine expression by reduction of NF-κB activity and AT1 receptor expression

Schmeißer, A., Soehnlein, O., Illmer, T., Lorenz, H., Eskafi, S., Rörick, O., Gabler, C., Strasser, R. H., Daniel, W. G., & Garlichs, C. D. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.10.059 · Cited by 79

The Effects of Statins and Renin‐Angiotensin System Blockers on Atrial Fibrillation Recurrence Following Antral Pulmonary Vein Isolation

Chekakie, M. O. A., Akar, J. G., Wang, F., Muradi, H. A., WU, J. M., Santucci, P. A., Varma, N., & Wilber, D. J. (2007) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2007.00887.x · Cited by 77

Effects of Ramipril on Endothelial Function and the Expression of Proinflammatory Cytokines and Adhesion Molecules in Young Normotensive Subjects With Successfully Repaired Coarctation of Aorta

Brili, S. V., Tousoulis, D., Antoniades, C. A., Vasiliadou, C., Karali, M., Παπαγεωργίου, Ν., Ioakeimidis, N., Marinou, K., Stefanadi, E., & Stefanadis, C. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.10.036 · Cited by 77

Deep-Sea Water Improves Cardiovascular Hemodynamics in Kurosawa and Kusanagi-Hypercholesterolemic (KHC) Rabbits

Katsuda, S.-I., Yasukawa, T., Nakagawa, K., Miyake, M., Yamasaki, M., Katahira, K., Mohri, M., Shimizu, T., & Hazama, A. (2008) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.31.38 · Cited by 76

Recent advances in intracellular signalling in hypertension

Touyz, R. M. (2003) · Current Opinion in Nephrology & Hypertension · doi:10.1097/00041552-200303000-00007 · Cited by 77

Deficiency of Angiotensin Type 2 Receptor Rescues Obesity But Not Hypertension Induced by Overexpression of Angiotensinogen in Adipose Tissue

Yvan‐Charvet, L., Massiéra, F., Lamandé, N., Ailhaud, G. P., Teboul, M., Moustaïd‐Moussa, N., Gasc, J., & Quignard‐Boulangé, A. (2008) · Endocrinology · doi:10.1210/en.2008-1120 · Cited by 75

RhoA Mediates Angiotensin II–Induced Phospho-Ser536 Nuclear Factor κB/RelA Subunit Exchange on the Interleukin-6 Promoter in VSMCs

Cui, R., Tieu, B. C., Recinos, A., Tilton, R. G., & Brasier, A. R. (2006) · Circulation Research · doi:10.1161/01.res.0000244015.10655.3f · Cited by 75

Fat intake modifies vascular responsiveness and receptor expression of vasoconstrictors: Implications for diet-induced obesity

Mundy, A. L., Haas, E., Bhattacharya, I., Widmer, C. C., Kretz, M., Hofmann‐Lehmann, R., Minotti, R., & Barton, M. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.11.019 · Cited by 75

Myocardial fibrosis in response to Angiotensin II is preceded by the recruitment of mesenchymal progenitor cells

Sopel, M. J., Rosin, N. L., Lee, T. D., & Légaré, J. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2010.190 · Cited by 72

Low level arsenic promotes progressive inflammatory angiogenesis and liver blood vessel remodeling in mice

Straub, A. C., Stolz, D. B., Vin, H., Ross, M. A., Soucy, N. V., Klei, L. R., & Barchowsky, A. (2006) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.10.011 · Cited by 72

Effect of the Renin-Angiotensin System Inhibitors on Inflammatory Markers: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Awad, K., Zaki, M. M., Mohammed, M., Lewek, J., Lavie, C. J., & Banach, M. (2022) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2022.06.036 · Cited by 71

Mast cells in vulnerable atherosclerotic plaques – a view to a kill

Lindstedt, K. A., Mäyränpää, M. I., & Kovanen, P. T. (2007) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00052.x · Cited by 75

The Proinflammatory Actions of Angiotensin II Are Dependent on p65 Phosphorylation by the IκB Kinase Complex

Douillette, A., Bibeau-Poirier, A., Gravel, S., Clément, J.-F., Chénard, V., Moreau, P. R., & Servant, M. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512815200 · Cited by 74

Cardiac-specific suppression of NF-κB signaling prevents diabetic cardiomyopathy via inhibition of the renin-angiotensin system

Thomas, C., Yong, Q. C., Rosa, R. M., Seqqat, R., Gopal, S., Casarini, D. E., Jones, W. K., Gupta, S., Baker, K. M., & Kumar, R. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00340.2014 · Cited by 70

The expression of macrophage migration inhibitory factor 1α (MIF 1α) in human atherosclerotic plaques is induced by different proatherogenic stimuli and associated with plaque instability

Schmeißer, A., Marquetant, R., Illmer, T., Graffy, C., Garlichs, C. D., Böckler, D., Menschikowski, D., Braun-Dullaeus, R. C., Daniel, W. G., & Strasser, R. H. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.08.038 · Cited by 69

Connecting chronic and recurrent stress to vascular dysfunction: no relaxed role for the renin-angiotensin system

Groeschel, M., & Braam, B. G. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00208.2010 · Cited by 69

Multiple actions of angiotensin II in hypertension

Schiffrin, E. L., & Touyz, R. M. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00845-3 · Cited by 68

FXR-mediated regulation of angiotensin type 2 receptor expression in vascular smooth muscle cells

Zhang, Q., He, F., Kuruba, R., Gao, X., Wilson, A. S., Li, J., Billiar, T. R., Pitt, B. R., Xie, W., & Li, S. (2007) · Cardiovascular Research · doi:10.1093/cvr/cvm068 · Cited by 68

Lipaemia, Inflammation and Atherosclerosis

van Oostrom, A. J. H. H. M., van Wijk, J. P. H., & Cabezas, M. C. (2004) · Drugs · doi:10.2165/00003495-200464002-00004 · Cited by 67

Physical inactivity causes endothelial dysfunction in healthy young mice

Suvorava, T., Lauer, N., & Kojda, G. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.06.030 · Cited by 66

Lack of vitamin D receptor causes stress-induced premature senescence in vascular smooth muscle cells through enhanced local angiotensin-II signals

Valcheva, P., Figueras, A. C., Panizo, S., Parisi, E., Božić, M., López-Novoa, J. M., Dusso, A., Fernández, E., & Valdivielso, J. M. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.05.911 · Cited by 65

Common genetic factors for depression and cardiovascular disease

Bondy, B. (2007) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2007.9.1/bbondy · Cited by 65

Adiponectin Expression Protects against Angiotensin II-Mediated Inflammation and Accelerated Atherosclerosis

van Stijn, C. M. W., Kim, J., Barish, G. D., Tietge, U. J. F., & Tangirala, R. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086404 · Cited by 64

Nature and Mediators of Parietal Epithelial Cell Activation in Glomerulonephritides of Human and Rat

Rizzo, P., Perico, N., Gagliardini, E., Novelli, R., Alison, M. R., Remuzzi, G., & Benigni, A. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.08.008 · Cited by 64

Angiotensin II Type 1A Receptors in Vascular Smooth Muscle Cells Do Not Influence Aortic Remodeling in Hypertension

Sparks, M. A., Parsons, K. K., Stegbauer, J., Gurley, S. B., Vivekanandan‐Giri, A., Fortner, C. N., Snouwaert, J., Raasch, E. W., Griffiths, R. C., Haystead, T., et al. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.165274 · Cited by 63

Costimulation with angiotensin II and interleukin 6 augments angiotensinogen expression in cultured human renal proximal tubular cells

Satou, R., González-Villalobos, R. A., Miyata, K., Ohashi, N., Katsurada, A., Navar, L. G., & Kobori, H. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00047.2008 · Cited by 64

Small-Molecule Inhibitors of Signal Transducer and Activator of Transcription 3 Protect Against Angiotensin II–Induced Vascular Dysfunction and Hypertension

Johnson, A. W., Kinzenbaw, D. A., Modrick, M. L., & Faraci, F. M. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00299 · Cited by 63

Anti-atherosclerotic properties of telmisartan in advanced atherosclerotic lesions in apolipoprotein E deficient mice

Blessing, E., Preusch, M. R., Kranzhöfer, R., Kinscherf, R., Marx, N., Rosenfeld, M. E., Isermann, B., Weber, C. M., Kreuzer, J., Gräfe, J., et al. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.10.037 · Cited by 63

Angiotensin II induces monocyte chemoattractant protein-1 expression via a nuclear factor-κB-dependent pathway in rat preadipocytes

Tsuchiya, K., Yoshimoto, T., Hirono, Y., Tateno, T., Sugiyama, T., & Hirata, Y. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00560.2005 · Cited by 62

(Pro)renin Receptor Promotes Choroidal Neovascularization by Activating Its Signal Transduction and Tissue Renin-Angiotensin System

Satofuka, S., Ichihara, A., Nagai, N., Noda, K., Ozawa, Y., Fukamizu, A., Tsubota, K., Itoh, H., Oike, Y., & Ishida, S. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.080457 · Cited by 65

Role of Asymmetric Dimethylarginine in Inflammatory Reactions by Angiotensin II

Chen, M., Xie, X.-M., Yang, T., Wang, Y., Zhang, X., Bai-lin, L., & Li, Y. (2007) · Journal of Vascular Research · doi:10.1159/000103284 · Cited by 62

Cooperation of SRC-1 and p300 With NF-κB and CREB in Angiotensin II-Induced IL-6 Expression in Vascular Smooth Muscle Cells

Sahar, S., Reddy, M. A., Wong, C., Meng, L. Y., Wang, M., & Natarajan, R. D. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.145862 · Cited by 62

Anti-Inflammatory Effects of AT1 Receptor Blockade Provide End-Organ Protection in Stroke-Prone Rats Independently from Blood Pressure Fall

Sironi, L., Gelosa, P., Guerrini, U., Banfi, C., Crippa, V., Brioschi, M., Gianazza, E., Nobili, E., Gianella, A., de Gasparo, M., et al. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.072066 · Cited by 61

Angioedema induced by angiotensin-converting enzyme inhibitors

Campo, P., Fernández, T. D., Cantó, G., & Mayorga, C. (2013) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e328362b835 · Cited by 59

Hypertension and cardiac arrhythmias: a review of the epidemiology, pathophysiology and clinical implications

Yiu, K., & Tse, H. (2008) · Journal of Human Hypertension · doi:10.1038/jhh.2008.10 · Cited by 58

Understanding mechanisms of hypertension in systemic lupus erythematosus

Taylor, E. B., & Ryan, M. J. (2016) · Therapeutic Advances in Cardiovascular Disease · doi:10.1177/1753944716637807 · Cited by 59

Angiotensin II Differentially Regulates Interleukin-1-β-inducible NO Synthase (iNOS) and Vascular Cell Adhesion Molecule-1 (VCAM-1) Expression

Jiang, B., Xu, S., Hou, X., Pimentel, D. R., & Cohen, R. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314172200 · Cited by 58

Angiotensin II activates JAK2/STAT3 pathway and induces interleukin-6 production in cultured rat brainstem astrocytes

Kandalam, U., & Clark, M. A. (2009) · Regulatory Peptides · doi:10.1016/j.regpep.2009.09.001 · Cited by 57

Telomere length and psychological well-being in patients with chronic heart failure

Huzen, J., van der Harst, P., de Boer, R. A., Lesman‐Leegte, I., Voors, A. A., van Gilst, W. H., Samani, N. J., Jaarsma, T., & van Veldhuisen, D. J. (2010) · Age and Ageing · doi:10.1093/ageing/afp256 · Cited by 58

Cardiac Angiotensin II Participates in Coronary Microvessel Inflammation of Unstable Angina and Strengthens the Immunomediated Component

Serneri, G. G. N., Boddi, M., Modesti, P. A., Coppo, M., Cecioni, I., Toscano, T., Papa, M. L., Bandinelli, M., Lisi, G. F., & Chiavarelli, M. (2004) · Circulation Research · doi:10.1161/01.res.0000130944.49657.b8 · Cited by 57

PDGF-induced vascular smooth muscle cell proliferation is associated with dysregulation of insulin receptor substrates

Zhao, Y., Biswas, S. K., McNulty, P. H., Kozak, M., Jun, J. Y., & Segar, L. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00670.2008 · Cited by 56

The Impact of the Renin-Angiotensin-Aldosterone System on Inflammation, Coagulation, and Atherothrombotic Complications, and to Aggravated COVID-19

Ekholm, M., & Kahan, T. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.640185 · Cited by 62

New-onset hypertension and inflammatory response/poor outcome in acute ischemic stroke

Rodríguez‐Yáñez, M., Castellanos, M., Blanco, M., García, M. M., Nombela, F., Serena, J. L., Leira, R., Lizasoaín, I., Dávalos, A., & Castillo, J. (2006) · Neurology · doi:10.1212/01.wnl.0000247064.53130.91 · Cited by 56

Role of AT-1 receptor in regulation of vascular MCP-1, IL-6, PAI-1, MAP kinase, and matrix expressions in obesity

Vaziri, N. D., Xu, Z., Shahkarami, A., Huang, K. T., Rodruguez-Iturbe, B., & Natarajan, R. D. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00750.x · Cited by 55

Role of Inflammation in Initiation and Perpetuation of Atrial Fibrillation: A Systematic Review of the Published Data.

Phillips, K. P. (2013) · Europe PMC (PubMed Central) · doi:10.4022/jafib.935 · Cited by 55

Angiotensin II type 1 receptor expression on human leukocyte subsets: A flow cytometric and RT-PCR study

Rasini, E., Cosentino, M., Marino, F., Legnaro, M., Ferrari, M., Guasti, L., Venco, A., & Lecchini, S. (2006) · Regulatory Peptides · doi:10.1016/j.regpep.2006.01.007 · Cited by 55

Critical Role of Bone Marrow Angiotensin II Type 1 Receptor in the Pathogenesis of Atherosclerosis in Apolipoprotein E–Deficient Mice

Fukuda, D., Sata, M., Ishizaka, N., & Nagai, R. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.152363 · Cited by 55

Endothelial Cell Regulation of Pulmonary Vascular Tone, Inflammation, and Coagulation

Goldenberg, N. M., & Kuebler, W. M. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140024 · Cited by 63

JAK-STAT and the renin-angiotensin system

Satou, R., & González-Villalobos, R. A. (2012) · JAK-STAT · doi:10.4161/jkst.22729 · Cited by 57

A Local Proinflammatory Signalling Loop Facilitates Adverse Age-Associated Arterial Remodeling

Wang, M., Spinetti, G., Monticone, R. E., Zhang, J., Wu, J. T., Jiang, L., Khazan, B., Telljohann, R. S., & Lakatta, E. G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016653 · Cited by 54

The Role of Angiotensin Type 1 Receptor in Inflammation and Endothelial Dysfunction

Skultetyova, D., Filipová, S., Riečanský, I., & Skultety, J. (2007) · Recent Advances in Cardiovascular Drug Discovery (Formerly Recent Patents on Cardiovascular Drug Discovery) · doi:10.2174/157489007779606130 · Cited by 54

Angiotensinogen and Megalin Interactions Contribute to Atherosclerosis—Brief Report

Ye, F., Ya, W., Wu, C., Howatt, D. A., Wu, C.-H., Balakrishnan, A., Mullick, A. E., Graham, M. J., Danser, A. H. J., Wang, J., et al. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.311817 · Cited by 54

HMG-CoA Reductase Inhibitors: Effects on Chronic Subacute Inflammation and Onset of Atherosclerosis Induced by Dietary Cholesterol

Kleemann, R., & Kooistra, T. (2005) · Cardiovascular & Haematological Disorders - Drug Targets · doi:10.2174/156800605774962077 · Cited by 54

Blockage of angiotensin II type 1 receptor regulates TNF-α-induced MAdCAM-1 expression via inhibition of NF-κB translocation to the nucleus and ameliorates colitis

Mizushima, T., Sasaki, M., Ando, T., Wada, T., Tanaka, M., Okamoto, Y., Ebi, M., Hirata, Y., Murakami, K., Mizoshita, T., et al. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00264.2009 · Cited by 53

Chronic hyperglicemia and nitric oxide bioavailability play a pivotal role in pro-atherogenic vascular modifications

Pandolfi, A., & Filippis, E. A. D. (2007) · Genes & Nutrition · doi:10.1007/s12263-007-0050-5 · Cited by 55

Lipid peroxidation, isoprostanes and vascular damage.

Minuz, P., Fava, C., & Lechi, A. (2006) · PubMed · Cited by 53

MAPK/AP-1 pathway activation mediates AT1R upregulation and vascular endothelial cells dysfunction under PM2.5 exposure

Xu, X., Xu, H., Qimuge, A., Liu, S., Wang, H., Hu, M., & Song, L. (2018) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2018.11.124 · Cited by 53

Long-Term, High-Dosage Candesartan Suppresses Inflammation and Injury in Chronic Kidney Disease

Yu, C., Gong, R., Rifai, A., Tolbert, E. M., & Dworkin, L. D. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006070770 · Cited by 53

The Sirt1 activator SRT1720 attenuates angiotensin II-induced atherosclerosis in apoE−/− mice through inhibiting vascular inflammatory response

Chen, Y. X., Zhang, M., Cai, Y., Zhao, Q., & Dai, W. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.08.066 · Cited by 53

Molecular Mechanism of Vitamin D in the Cardiovascular System

Li, Y. C. (2011) · Journal of Investigative Medicine · doi:10.2310/jim.0b013e31820ee448 · Cited by 52

Upregulation of sestrin-2 expression protects against endothelial toxicity of angiotensin II

Lao, Y., Li, F., Yong, Y., Dong, J., Zhang, L., Huang, X., Li, F., & Jiewen, L. (2014) · Cell Biology and Toxicology · doi:10.1007/s10565-014-9276-3 · Cited by 52

Cigarette smoke enhances abdominal aortic aneurysm formation in angiotensin II-treated apolipoprotein E-deficient mice

Stolle, K., Berges, A., Lietz, M., Lebrun, S., & Wallerath, T. (2010) · Toxicology Letters · doi:10.1016/j.toxlet.2010.10.005 · Cited by 52

Angiotensin-Receptor Blockade Reduces Border Zone Myocardial Monocyte Chemoattractant Protein-1 Expression and Macrophage Infiltration in Post-Infarction Ventricular Remodeling

Kohno, T., Anzai, T., Naito, K., Sugano, Y., Maekawa, Y., Takahashi, T., Yoshikawa, T., & Ogawa, S. (2008) · Circulation Journal · doi:10.1253/circj.cj-08-0115 · Cited by 52

Relationship between renal function and the risk of recurrent atrial fibrillation following catheter ablation

Tokuda, M., Yamane, T., Matsuo, S., Ito, K., Narui, R., Hioki, M., Tanigawa, S., Nakane, T., Yamashita, S., Inada, K., et al. (2010) · Heart · doi:10.1136/hrt.2010.200824 · Cited by 52

Equisetum arvense L. Extract Induces Antibacterial Activity and Modulates Oxidative Stress, Inflammation, and Apoptosis in Endothelial Vascular Cells Exposed to Hyperosmotic Stress

Pallag, A., Filip, G. A., Olteanu, D. E., Clichici, S. V., Bâldea, I., Jurca, T., Micle, O., Vicaș, L. G., Marian, E., Şoriţău, O., et al. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/3060525 · Cited by 54

Angiotensin II and leukocyte trafficking: New insights for an old vascular mediator. Role of redox-signaling pathways

Piqueras, L., & Sanz, M. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.02.002 · Cited by 51

Blood pressure lowering after experimental cerebral ischemia provides neurovascular protection

Elewa, H. F., Kozak, A., Johnson, M. H., Ergul, A., & Fagan, S. C. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e3280149708 · Cited by 51

ACE gene titration in mice uncovers a new mechanism for ACE on the control of body weight

Heimann, A. S., Favarato, M. H. S., Gozzo, F. C., Rioli, V., Carreno, F. R., Eberlin, M. N., Ferro, E. S., Krege, J. H., & Krieger, J. E. (2004) · Physiological Genomics · doi:10.1152/physiolgenomics.00145.2004 · Cited by 51

Role of Rho-Kinase and p27 in Angiotensin II–Induced Vascular Injury

Kanda, T., Hayashi, K., Wakino, S., Homma, K., Yoshioka, K., Hasegawa, K., Sugano, N., Tatematsu, S., Takamatsu, I., Mitsuhashi, T., et al. (2005) · Hypertension · doi:10.1161/01.hyp.0000153316.59262.79 · Cited by 51

Dalcetrapib: no off‐target toxicity on blood pressure or on genes related to the renin‐angiotensin‐aldosterone system in rats

Stroes, E. S. G., Kastelein, J. J. P., Benardeau, A. M., Kuhlmann, O., Blum, D., Campos, L. A., Clerc, R. G., & Niesor, E. J. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00460.x · Cited by 50

Cytokine imbalance in acute coronary syndrome

Alam, S. (2004) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2003.10.011 · Cited by 50

Diabetes and Inflammation

Cosentino, F., & Assenza, G. E. (2004) · Herz · doi:10.1007/s00059-004-2635-8 · Cited by 51

Genetic Determinants of Arterial Calcification Associated With Atherosclerosis

Doherty, T. M., Fitzpatrick, L. A., Shaheen, A., Rajavashisth, T. B., & Detrano, R. (2004) · Mayo Clinic Proceedings · doi:10.4065/79.2.197 · Cited by 49

Telmisartan Exerts Antiatherosclerotic Effects by Activating Peroxisome Proliferator-Activated Receptor-γ in Macrophages

Matsumura, T., Kinoshita, H., Ishii, N., Fukuda, K., Motoshima, H., Senokuchi, T., Taketa, K., Kawasaki, S., Nishimaki‐Mogami, T., Kawada, T., et al. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.222067 · Cited by 49

The effects of captopril on lipopolysaccharide induced learning and memory impairments and the brain cytokine levels and oxidative damage in rats

Abareshi, A., Hosseini, M., Beheshti, F., Norouzi, F., Khazaei, M., Sadeghnia, H. R., Boskabady, M. H., Shafei, M. N., & Anaeigoudari, A. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.10.026 · Cited by 49

Pyrrolidine dithiocarbamate down-regulates vascular matrix metalloproteinases and ameliorates vascular dysfunction and remodelling in renovascular hypertension

Cáu, S. B. D. A., Guimarães, D. A., Rizzi, É., Ceron, C. S., Souza, L. L., Tirapelli, C. R., Gerlach, R. F., & Tanus-Santos, J. E. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01360.x · Cited by 47

Vascular and plaque imaging with ultrasmall superparamagnetic particles of iron oxide

Alam, S. R., Stirrat, C., Richards, J. M. J., Mirsadraee, S., Semple, S. I. K., Tse, G. H., Henriksen, P. A., & Newby, D. E. (2015) · Journal of Cardiovascular Magnetic Resonance · doi:10.1186/s12968-015-0183-4 · Cited by 48

IL-6 augments angiotensinogen in primary cultured renal proximal tubular cells

Satou, R., González-Villalobos, R. A., Miyata, K., Ohashi, N., Urushihara, M., Acres, O. W., Navar, L. G., & Kobori, H. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.06.013 · Cited by 47

Angiotensin II and vascular inflammation.

Cheng, Z. J., Vapaatalo, H., & Mervaala, E. M. A. (2005) · PubMed · Cited by 236

Role of the Renin-Angiotensin System in Vascular Diseases

Ruiz‐Ortega, M., Lorenzo, Ó., Rupérez, M., Esteban, V., Suzuki, Y., Mezzano, S. A., Plaza, J. J. G., & Egido, J. (2001) · Hypertension · doi:10.1161/hy1201.100589 · Cited by 317

Angiotensin Induces Inflammatory Activation of Human Vascular Smooth Muscle Cells

Kranzhöfer, R., Schmidt, J., Pfeiffer, C. A. H., Hagl, S., Libby, P., & Kübler, W. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.7.1623 · Cited by 483

Angiotensin II and atherosclerosis

Weiss, D., Sorescu, D., & Taylor, W. R. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)01539-9 · Cited by 180

From endothelial dysfunction to vascular occlusion: role of the renin-angiotensin system.

Silva, P. M. (2010) · PubMed · Cited by 10