The DOI matches its Crossref record; 104 of the 104 references it cites were found in a registry or an index.
Notch Signaling in Vascular Development
Open accessAbstract
Notch signaling is an extremely conserved and widely used mechanism regulating cell fate in metazoans. Interaction of Notch receptors (Notch) with their ligands (Delta-like or Jagged) leads to cleavage of the Notch intracellular domain (NICD) that migrates into the nucleus. In the nucleus, NICD associates with a transcription factor, RBP-Jk. The NICD-RBP-Jk complex, in turn, upregulates expression of primary target genes of Notch signaling, such as hairy and enhancer of split (HES) and HES-related repressor protein (HERP) transcriptional repressors. Recent evidence has demonstrated that the Notch pathway is involved in multiple aspects of vascular development, including proliferation, migration, smooth muscle differentiation, angiogenic processes, and arterial-venous differentiation. In this brief review, we focus on ligands, receptors, and target genes of Notch signaling in the vascular system and discuss (1) tissue distribution; (2) gain- and loss-of-function studies; and (3) the role of Notch components in human diseases involving the vascular system.
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Cites
Notch Signaling: Cell Fate Control and Signal Integration in Development
Artavanis-Tsakonas, S., Rand, M. D., & Lake, R. J. (1999) · Science · doi:10.1126/science.284.5415.770 · Cited by 5,909
Mechanisms of angiogenesis and arteriogenesis
Carmeliet, P. (2000) · Nature Medicine · doi:10.1038/74651 · Cited by 4,162
Vascular-specific growth factors and blood vessel formation
Yancopoulos, G. D., Davis, S., Gale, N. W., Rudge, J. S., Wiegand, S. J., & Holash, J. (2000) · Nature · doi:10.1038/35025215 · Cited by 3,699
Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia
Joutel, A., Corpechot, C., Ducros, A., Vahedi, K., Chabriat, H., Mouton, P., Alamowitch, S., Domenga, V., Cécillion, M., Maréchal, E., et al. (1996) · Nature · doi:10.1038/383707a0 · Cited by 2,068
Ellisen, L. W., Bird, J., West, D. C., Soreng, A. L., Reynolds, T. C., Smith, S. D., & Sklar, J. (1991) · Cell · doi:10.1016/0092-8674(91)90111-b · Cited by 1,696
Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1
Li, L., Krantz, I. D., Deng, Y., Genin, A., Banta, A. B., Collins, C. C., Qi, M., Trask, B. J., Kuo, W. L., Cochran, J., et al. (1997) · Nature Genetics · doi:10.1038/ng0797-243 · Cited by 1,284
HES and HERP families: Multiple effectors of the notch signaling pathway
Iso, T., Kedes, L., & Hamamori, Y. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10208 · Cited by 1,238
Self-citationNotch signalling controls pancreatic cell differentiation
Apelqvist, Å., Li, H., Sommer, L., Beatus, P., Anderson, D. J., Honjo, T., de Angelis, M. H., Lendahl, U., & Edlund, H. (1999) · Nature · doi:10.1038/23716 · Cited by 1,159
Mutations in the human Jagged1 gene are responsible for Alagille syndrome
Oda, T., Elkahloun, A. G., Pike, B. L., Okajima, K., Krantz, I. D., Genin, A., Piccoli, D. A., Meltzer, P. S., Spinner, N. B., Collins, F. S., et al. (1997) · Nature Genetics · doi:10.1038/ng0797-235 · Cited by 1,158
Notch signaling is essential for vascular morphogenesis in mice
Krebs, L. T., Xue, Y., Norton, C. R., Shutter, J. R., Maguire, M., Sundberg, J. P., Gallahan, D., Closson, V., Kitajewski, J., Callahan, R., et al. (2000) · Genes & Development · doi:10.1101/gad.14.11.1343 · Cited by 1,060
Cited by
Slug is a direct Notch target required for initiation of cardiac cushion cellularization
Niessen, K., Fu, Y., Chang, L., Hoodless, P. A., McFadden, D., & Karsan, A. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200710067 · Cited by 363
Patel, N. S., Li, J.-L., Generali, D., Poulsom, R., Cranston, D. W., & Harris, A. L. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1208 · Cited by 349
Critical role of endothelial Notch1 signaling in postnatal angiogenesis
Takeshita, K., Satoh, M., Ii, M., Silver, M., Limbourg, F. P., Mukai, Y., Rikitake, Y., Radtke, F., Gridley, T., Losordo, D. W., et al. (2007) · Circulation Research · doi:10.1161/01.res.0000254788.47304.6e · Cited by 232
Baladrón, V., Ruiz-Hidalgo, M. J., Nueda, M. L., Díaz-Guerra, M. J. M., García-Ramírez, J. J., Bonvini, E., Gubina, E., & Laborda, J. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.10.001 · Cited by 226
Co-ordinating Notch, BMP, and TGF-β signaling during heart valve development
Garside, V. C., Chang, A. C., Karsan, A., & Hoodless, P. A. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1197-9 · Cited by 160
Metadata
- Authors
- Iso, T., Hamamori, Y., & Kedes, L.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2003-04
- Volume
- 23
- Issue
- 4
- Pages
- 543-553
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2158250531
- Cited by
- 382
- References
- 104
- FWCI
- 7.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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