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Platelets in Inflammation and Thrombosis
Abstract
For many years it has been known that platelets play an important role in thrombosis and hemostasis. In recent times, however, it has become evident that platelets also have relevant functions in inflammation. It was shown that thrombosis and inflammation share several key molecular mechanisms and in fact are 2 intrinsically linked processes. In this review, we intend to give a short overview with emphasis on work stemming from our laboratory.
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“Consequent to vascular damage, activated platelets can also release an array of cellular growth factors and angiogenic factors such as PDGF and VEGF, as well as inflammatory mediators such as IL-8 [79,80,81].”
From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [81]
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Metadata
- Authors
- Wagner, D. D., & Burger, P. C.
- Affiliations
- Harvard University (US)
- Venue
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2003-12
- Volume
- 23
- Issue
- 12
- Pages
- 2131-2137
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2169304723
- Cited by
- 570
- References
- 91
- Citations by year
- 2026: 11 · 2025: 10 · 2024: 17 · 2023: 18 · 2022: 29 · 2021: 19 · 2020: 23 · 2019: 21 · 2018: 21 · 2017: 18 · 2016: 35 · 2015: 30 · 2014: 40 · 2013: 28 · 2012: 32
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01-HL-53756, P01 HL 56949, R37HL041002, P01HL056949, R37 HL 41002, R01HL053756)
- Topics
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- platelets, inflammation, thrombosis, hemostasis, platelet function
- MeSH terms
- Animals, Blood Platelets, Endothelium, Vascular, Humans, Inflammation, Thrombosis
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