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Platelets in Inflammation and Thrombosis
Abstract
For many years it has been known that platelets play an important role in thrombosis and hemostasis. In recent times, however, it has become evident that platelets also have relevant functions in inflammation. It was shown that thrombosis and inflammation share several key molecular mechanisms and in fact are 2 intrinsically linked processes. In this review, we intend to give a short overview with emphasis on work stemming from our laboratory.
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“Consequent to vascular damage, activated platelets can also release an array of cellular growth factors and angiogenic factors such as PDGF and VEGF, as well as inflammatory mediators such as IL-8 [79,80,81].”
From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [81]
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Metadata
- Authors
- Wagner, D. D., & Burger, P. C.
- Affiliations
- Harvard University (US)
- Venue
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2003-12
- Volume
- 23
- Issue
- 12
- Pages
- 2131-2137
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2169304723
- Cited by
- 570
- References
- 91
- Citations by year
- 2026: 11 · 2025: 10 · 2024: 17 · 2023: 18 · 2022: 29 · 2021: 19 · 2020: 23 · 2019: 21 · 2018: 21 · 2017: 18 · 2016: 35 · 2015: 30 · 2014: 40 · 2013: 28 · 2012: 32
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01-HL-53756, P01 HL 56949, R37HL041002, P01HL056949, R37 HL 41002, R01HL053756)
- Topics
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- platelets, inflammation, thrombosis, hemostasis, platelet function
- MeSH terms
- Animals, Blood Platelets, Endothelium, Vascular, Humans, Inflammation, Thrombosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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