The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Nonalcoholic Fatty Liver Disease Is Associated With Carotid Atherosclerosis: A Case–Control Study
Abstract
Objective— Nonalcoholic fatty liver disease (NAFLD) frequently coexists with obesity, diabetes, and dyslipidemia. We examined whether NAFLD was associated with atherosclerosis, as measured by ultrasound in the carotid arteries. Methods and Results— Carotid atherosclerosis and cardiovascular risk factors were assessed in 40 patients with an ultrasound diagnosis of primary NAFLD and 40 matched population controls. The metabolic syndrome and all its individual traits, including elevated C-reactive protein, were significantly ( P <0.005) more frequent in NAFLD patients than in control subjects. Patients with NAFLD showed more carotid atherosclerosis than controls, with mean intima-media thickness (IMT) of 0.70±0.20 mm and 0.54±0.13 mm ( P <0.0001) and plaque prevalence of 50% and 25% ( P =0.021), respectively. By multivariate analysis, older age (odds ratio [OR], 2.5 per 10 years; 95% CI, 1.4 to 4.4; P =0.002), the presence of NAFLD (OR, 8.4; 95% CI, 2.49 to 29.4; P =0.001), and elevated serum ferritin (OR, 3.1; 95% CI, 1.2 to 7.9; P =0.016) were independent predictors of an increased IMT. Conclusions— Patients with NAFLD show a cluster of risk factors of the metabolic syndrome and advanced carotid atherosclerosis. NAFLD appears to be a feature of the metabolic syndrome, and its detection on abdominal ultrasound should alert to the existence of an increased cardiovascular risk.
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Nonalcoholic Fatty Liver Disease
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Cited by
Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease
Targher, G., Day, C. P., & Bonora, E. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0912063 · Cited by 1,907
Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis
Anstee, Q. M., Targher, G., & Day, C. P. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.41 · Cited by 1,747
Identification and characterization of metabolically benign obesity in humans
Stefan, N. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.15.1609 · Cited by 1,049
Cusi, K. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.02.003 · Cited by 911
Long-Term Follow-Up of Patients With Nonalcoholic Fatty Liver
Rafiq, N., Bai, C., Fang, Y., Srishord, M., McCullough, A., Gramlich, T., & Younossi, Z. M. (2009) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2008.11.005 · Cited by 729
Metadata
- Authors
- Brea, A., Mosquera, D., Martín, E., Arizti, A., Cordero, J. L., & Ros, E.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2005-05
- Volume
- 25
- Issue
- 5
- Pages
- 1045-1050
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2123796944
- Cited by
- 387
- References
- 12
- FWCI
- 18.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- Brea, A., Mosquera, D., Martín, E., Arizti, A., Cordero, J. L., & Ros, E. (2005). Nonalcoholic Fatty Liver Disease Is Associated With Carotid Atherosclerosis: A Case–Control Study. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/01.atv.0000160613.57985.18
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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