The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Elevated Interleukin-18 Levels Are Associated With the Metabolic Syndrome Independent of Obesity and Insulin Resistance
Abstract
Objective— Activated innate immunity is thought to be involved in the pathogenesis of metabolic syndrome and type 2 diabetes. Interleukin-18 (IL-18) is a pleiotropic proinflammatory cytokine with important regulatory functions in the innate immune response. We sought to determine whether an elevated IL-18 concentration was a risk predictor for metabolic syndrome in a community population independent of obesity and hyperinsulinemia. Methods and Results— A representative general population, aged 27 to 77 years, without clinical diabetes was studied for clinical and biochemical risk factors for metabolic syndrome. Serum IL-18 concentration measured in 955 subjects correlated with metabolic syndrome traits including body mass index (BMI), waist circumference, triglyceride, high-density lipoprotein (inversely), and fasting glucose and insulin levels (all P <0.001). Mean IL-18 levels rose progressively with the increasing number of metabolic risk factors (ANOVA P <0.001). After adjusting for age, gender, BMI, and insulin levels, increasing IL-18 tertiles were associated with an odds ratio for metabolic syndrome of 1.0, 1.42, and 2.28, respectively ( P trend=0.007). The graded risk relation was even stronger in nonobese subjects and not attenuated when adjusted for C-reactive protein and IL-6 levels. Conclusion— Our findings support the hypothesis that activation of IL-18 is involved in the pathogenesis of the metabolic syndrome.
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The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men
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Danesh, J., Wheeler, J. G., Hirschfield, G. M., Eda, S., Eiriksdottir, G., Rumley, A., Lowe, G. D. O., Pepys, M. B., & Gudnason, V. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032804 · Cited by 2,953
Clinical application of C-reactive protein for cardiovascular disease detection and prevention
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Inflammation and Activated Innate Immunity in the Pathogenesis of Type 2 Diabetes
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Cited by
Cornier, M.-A., Dabelea, D., Hernandez, T. L., Lindstrom, R. C., Steig, A. J., Stob, N. R., Van Pelt, R. E., Wang, H., & Eckel, R. H. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0024 · Cited by 2,162
Inflammation in Atherosclerosis: From Vascular Biology to Biomarker Discovery and Risk Prediction
Packard, R. R. S., & Libby, P. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2007.097360 · Cited by 925
Role of the Immune System in Hypertension
Rodriguez-Iturbe, B., Pons, H., & Johnson, R. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00031.2016 · Cited by 391
Fischer, C. P., Berntsen, A., Perstrup, L. B., Eskildsen, P., & Pedersen, B. K. (2007) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/j.1600-0838.2006.00602.x · Cited by 230
Soy Consumption, Markers of Inflammation, and Endothelial Function
Azadbakht, L., Kimiagar, M., Mehrabi, Y., Esmaillzadeh, A., Hu, F. B., & Willett, W. C. (2007) · Diabetes Care · doi:10.2337/dc06-2126 · Cited by 178
Metadata
- Authors
- Hung, J., McQuillan, B. M., Chapman, C. M. L., Thompson, P. L., & Beilby, J. P.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2005-06
- Volume
- 25
- Issue
- 6
- Pages
- 1268-1273
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2099790921
- Cited by
- 241
- References
- 14
- FWCI
- 12.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hung, J., McQuillan, B. M., Chapman, C. M. L., Thompson, P. L., & Beilby, J. P. (2005). Elevated Interleukin-18 Levels Are Associated With the Metabolic Syndrome Independent of Obesity and Insulin Resistance. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/01.atv.0000163843.70369.12
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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