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Cited by 178Phytoestrogen effects and researchNutritional Studies and DietFatty Acid Research and Health

Soy Consumption, Markers of Inflammation, and Endothelial Function

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Azadbakht, Leila, Kimiagar, Masoud, Mehrabi, Yadollah, Esmaillzadeh, Ahmad, Hu, Frank B., Willett, Walter C.·2007·Diabetes Care
DOI 10.2337/dc06-2126
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Abstract

OBJECTIVE: To determine the effects of soy consumption on markers of inflammation and endothelial function in postmenopausal women with the metabolic syndrome. RESEARCH DESIGN AND METHODS: This randomized cross-over clinical trial included 42 postmenopausal women with the metabolic syndrome. Participants were randomly assigned to consume a control diet (Dietary Approaches to Stop Hypertension [DASH]), soy protein diet, or soy nut diet, each for 8 weeks. Red meat in the DASH diet (one serving/day) was replaced by soy protein in the soy protein diet and by soy nut in the soy nut diet. RESULTS: For nitric oxide levels, the difference from the control diet was 9.8% (P < 0.01) on the soy nut and -1.7% (P = 0.10) on the soy protein diets. The difference from the control diet for serum E-selectin was -11.4% (P < 0.01) on the soy nut consumption and -4.7% (P = 0.19) on the soy protein diet. Soy nut consumption reduced interleukin-18 compared with the control diet (difference from the control diet: -9.2%, P < 0.01), but soy protein did not (difference from the control diet: -4.6%, P = 0.14). For C-reactive protein, the difference from the control diet was -8.9% (P < 0.01) on the soy nut diet and -1.6% (P < 0.01) on the soy protein diet. CONCLUSIONS: Short-term soy nut consumption reduced some markers of inflammation and increased plasma nitric oxide levels in postmenopausal women with the metabolic syndrome.

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Authors
Azadbakht, L., Kimiagar, M., Mehrabi, Y., Esmaillzadeh, A., Hu, F. B., & Willett, W. C.
Affiliations
  • Isfahan University of Medical Sciences (IR)
  • Department of Human Nutrition, School of Nutrition and Food Science
  • Shahid Beheshti University (IR)
  • Harvard University (US)
ORCID
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
2007-04-01
Volume
30
Issue
4
Pages
967-973
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/dc06-2126
OpenAlex
W2031463875
Cited by
178
References
46
Citations by year
2026: 3 · 2025: 7 · 2024: 5 · 2023: 3 · 2022: 7 · 2021: 10 · 2020: 9 · 2019: 6 · 2018: 7 · 2017: 8 · 2016: 8 · 2015: 11 · 2014: 15 · 2013: 14 · 2012: 15
FWCI
8.74
Type
journal article
Language
en
Open access
Locations
  • Diabetes Care (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Nutrition and Food Technology Research Institute
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords
soy consumption, soy protein, inflammation, endothelial function, nitric oxide, E-selectin, IL-18, C-reactive protein, metabolic syndrome, postmenopausal women, DASH diet
MeSH terms
Aged, C-Reactive Protein, Endothelium, Vascular, Female, Humans, Hypertension, Inflammation, Interleukins, Iran, Phytotherapy, Middle Aged, Nitric Oxide, Risk Factors, Biomarkers, Postmenopause, Cross-Over Studies, Intercellular Adhesion Molecule-1, Vascular Cell Adhesion Molecule-1, Metabolic Syndrome, Soybean Proteins, Soy Foods

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