The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Lipoprotein-Associated Phospholipase A 2 Protein Expression in the Natural Progression of Human Coronary Atherosclerosis
Open accessAbstract
Objective— Although lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ) has received recent attention as a biomarker of inflammation and risk for acute coronary events, its relative expression in coronary plaque phenotypes, including unstable lesions, has not been established. Methods and Results— Coronary segments (n=30) were prospectively collected from 25 sudden coronary death patients for immunolocalization of Lp-PLA 2 . Lesion morphologies were classified as pathologic intimal thickening, fibroatheromas, thin-cap fibroatheromas (fibrous cap thicknesses <65 μm), and rupture. The expression of Lp-PLA 2 was detected using a specific monoclonal antibody. Apoptosis was identified by DNA end-labeling using terminal deoxynucleotidyl transferase (TdT). Lp-PLA 2 staining in early plaques was absent or minimally detected. In contrast, thin-cap fibroatheromas and ruptured plaques showed intense Lp-PLA 2 expression within necrotic cores and surrounding macrophages including those in the fibrous cap. The degree of macrophage apoptosis was greater in thin-cap fibroatheroma and ruptures compared with less advanced plaques with additional double labeling studies showing Lp-PLA 2 present in apoptotic cells in regions of high macrophage density. Conclusions— Lp-PLA 2 is strongly expressed within the necrotic core and surrounding macrophages of vulnerable and ruptured plaques, with relatively weak staining in less advanced lesions. These findings together with the association of Lp-PLA 2 in apoptotic macrophages suggest a potential role in promoting plaque instability.
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Cites
Inflammation, Atherosclerosis, and Coronary Artery Disease
Hansson, G. K. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043430 · Cited by 8,773
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Self-citationPathology of the Vulnerable Plaque
Virmani, R., Burke, A. P., Farb, A., & Kolodgie, F. D. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.10.065 · Cited by 2,315
Self-citationIntraplaque Hemorrhage and Progression of Coronary Atheroma
Kolodgie, F. D., Gold, H. K., Burke, A. P., Fowler, D. R., Kruth, H. S., Weber, D. K., Farb, A., Guerrero, L. J., Hayase, M., Kutys, R., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035655 · Cited by 1,486
Self-citationC-Reactive Protein as a Cardiovascular Risk Factor: More Than an Epiphenomenon?
Lagrand, W. K., Visser, C. A., Hermens, W. T., Niessen, H. W. M., Verheugt, F. W. A., Wolbink, G.-J., & Hack, C. E. (1999) · Circulation · doi:10.1161/01.cir.100.1.96 · Cited by 833
Lipoprotein-Associated Phospholipase A2as an Independent Predictor of Coronary Heart Disease
Packard, C. J., O'Reilly, D. S. J., Caslake, M. J., McMahon, A. D., Ford, I., Cooney, J., Macphee, C. H., Suckling, K. E., Krishna, M., Wilkinson, F. E., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200010193431603 · Cited by 823
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Self-citationBallantyne, C. M., Hoogeveen, R. C., Bang, H., Coresh, J., Folsom, A. R., Heiss, G., & Sharrett, A. R. (2004) · Circulation · doi:10.1161/01.cir.0000116763.91992.f1 · Cited by 613
Cited by
Update on acute coronary syndromes: the pathologists' view
Falk, E., Nakano, M., Bentzon, J. F., Finn, A. V., & Virmani, R. (2013) · European Heart Journal · doi:10.1093/eurheartj/ehs411 · Cited by 1,047
Self-citationDarapladib for Preventing Ischemic Events in Stable Coronary Heart Disease
The STABILITY Investigators (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1315878 · Cited by 579
The role of oxidized phospholipids in mediating lipoprotein(a) atherogenicity
Tsimikas, S., & Witztum, J. L. (2008) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328308b622 · Cited by 138
Grallert, H., Dupuis, J., Bis, J. C., Dehghan, A., Barbalic, M., Baumert, J., Lu, C., Smith, N. L., Uitterlinden, A. G., Roberts, R., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehr372 · Cited by 83
Metadata
- Authors
- Kolodgie, F. D., Burke, A. P., Skorija, K. S., Ladich, E., Kutys, R., Makuria, A. T., & Virmani, R.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2006-11
- Volume
- 26
- Issue
- 11
- Pages
- 2523-2529
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2155040156
- Cited by
- 309
- References
- 47
- FWCI
- 9.14
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kolodgie, F. D., Burke, A. P., Skorija, K. S., Ladich, E., Kutys, R., Makuria, A. T., & Virmani, R. (2006). Lipoprotein-Associated Phospholipase A 2 Protein Expression in the Natural Progression of Human Coronary Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/01.atv.0000244681.72738.bc
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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