Abdominal Aortic Aneurysm: Pathogenesis and Implications for Management

Golledge, Jonathan; Muller, Juanita; Daugherty, Alan; Norman, Paul

doi:10.1161/01.atv.0000245819.32762.cb

Cited by 625Aortic aneurysm repair treatmentsAortic Disease and Treatment ApproachesConnective tissue disorders research

Abdominal Aortic Aneurysm: Pathogenesis and Implications for Management

Golledge, Jonathan, Muller, Juanita, Daugherty, Alan, Norman, Paul·2006·Arteriosclerosis Thrombosis and Vascular Biology

DOI 10.1161/01.atv.0000245819.32762.cb

Open this paper in CoChat — free account

Abstract

Abdominal aortic aneurysm (AAA) affects approximately 5% of elderly men and is responsible for a significant number of deaths in Western Countries. At present surgery by open or endovascular means is the only widely used therapy for this condition. In this review we examine the risk factors, serum, and genetic associations of AAA. Epidemiology studies suggest that smoking cessation and control of cholesterol and blood pressure should reduce the number of patients developing AAA. Natural history studies suggest that smoking cessation should reduce the rate of progression of AAA. Clear level 1 evidence for drug treatments of AAA are presently lacking; however, animal and human in vitro studies suggest that medication targeted at reducing inflammation and proteolysis are most likely to be beneficial, with limited data to support the use of statins, Angiotensin II inhibitors, and macrolides. Work has commenced in understanding which patients, identified by clinical, serum, and genotype, are more at risk of AAA progression and thus should be selected out for aggressive treatment. Well designed large multicenter randomized controlled trials are required to examine the medical treatment of AAA.

Integrity signals

Registry

Crossref · 10.1161/01.atv.0000245819.32762.cb

Cites

116 of 116 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Abdominal aortic aneurysm is a risk-equivalent condition and is associated with age, male sex, personal history of atherosclerotic cardiovascular disease, smoking, hypertension and dyslipidaemia, while diabetic patients are at decreased risk.
“The presence of an abdominal aortic aneurysm represents a riskequivalent condition and is associated with age, male gender, personal history of atherosclerotic CVD, smoking, hypertension and dyslipidaemia, 415 while, in contrast, diabetic patients are at decreased risk.”
From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [415]

A haplotype map of the human genome
The International HapMap Consortium (2005) · Nature · doi:10.1038/nature04226 · Cited by 5,858 · see citing works
Endovascular aneurysm repair versus open repair in patients with abdominal aortic aneurysm (EVAR trial 1): randomised controlled trial
* (2005) · The Lancet · doi:10.1016/s0140-6736(05)66627-5 · Cited by 1,540 · see citing works
Mortality results for randomised controlled trial of early elective surgery or ultrasonographic surveillance for small abdominal aortic aneurysms
(1998) · The Lancet · doi:10.1016/s0140-6736(98)10137-x · Cited by 1,184 · see citing works
Immediate Repair Compared with Surveillance of Small Abdominal Aortic Aneurysms
Lederle, F. A., Wilson, S. E., Johnson, G. R., Reinke, D. B., Littooy, F. N., Acher, C. W., Ballard, D., Messina, L. M., Gordon, I. L., Chute, E. P., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012573 · Cited by 1,077 · see citing works
Prevalence and Associations of Abdominal Aortic Aneurysm Detected through Screening
Lederle, F. A., Johnson, G. R., Wilson, S. E., Chute, E. P., Littooy, F. N., Bandyk, D. F., Krupski, W. C., Barone, G. W., Acher, C. W., & Ballard, D. (1997) · Annals of Internal Medicine · doi:10.7326/0003-4819-126-6-199703150-00004 · Cited by 910 · see citing works
Risk of cardiovascular events and rofecoxib: cumulative meta-analysis
Jüni, P., Nartey, L., Reichenbach, S., Sterchi, R., Dieppe, P. A., & Egger, M. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17514-4 · Cited by 846 · see citing works
Endovascular aneurysm repair and outcome in patients unfit for open repair of abdominal aortic aneurysm (EVAR trial 2): randomised controlled trial
* (2005) · The Lancet · doi:10.1016/s0140-6736(05)66628-7 · Cited by 838 · see citing works
Risk Factors for Aneurysm Rupture in Patients Kept Under Ultrasound Surveillance
Brown, L. C., & Powell, J. T. (1999) · Annals of Surgery · doi:10.1097/00000658-199909000-00002 · Cited by 705 · see citing works
Abdominal Aortic Aneurysm Expansion
Brady, T., Thompson, S. G., Fowkes, F. G. R., Greenhalgh, R. M., & Powell, J. T. (2004) · Circulation · doi:10.1161/01.cir.0000133279.07468.9f · Cited by 682 · see citing works
Prevalence of and Risk Factors for Abdominal Aortic Aneurysms in a Population-based Study : The Tromso Study
Singh, K. (2001) · American Journal of Epidemiology · doi:10.1093/aje/154.3.236 · Cited by 635 · see citing works
Inflammation and Cellular Immune Responses in Abdominal Aortic Aneurysms
Shimizu, K., Mitchell, R. N., & Libby, P. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000214999.12921.4f · Cited by 624 · see citing works
Rupture Rate of Large Abdominal Aortic Aneurysms in Patients Refusing or Unfit for Elective Repair
Lederle, F. A. (2002) · JAMA · doi:10.1001/jama.287.22.2968 · Cited by 607 · see citing works
Screening for Abdominal Aortic Aneurysm: A Best-Evidence Systematic Review for the U.S. Preventive Services Task Force
Fleming, C., Whitlock, E. P., Beil, T. L., & Lederle, F. A. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-142-3-200502010-00012 · Cited by 503 · see citing works
Mouse Models of Abdominal Aortic Aneurysms
Daugherty, A., & Cassis, L. A. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000118013.72016.ea · Cited by 489 · see citing works
Self-citation
What makes a good genetic association study?
Hattersley, A. T., & McCarthy, M. I. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67531-9 · Cited by 465 · see citing works
Cystatin C deficiency in human atherosclerosis and aortic aneurysms
Shi, G.-P., Sukhova, G. K., GRUBB, A. O., Ducharme, A., Rhode, L. H., Lee, R. T., Ridker, P. M., Libby, P., & Chapman, H. A. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7709 · Cited by 456 · see citing works
Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase
Yoshimura, K., Aoki, H., Ikeda, Y., Fujii, K., Akiyama, N., Furutani, A., Hoshii, Y., Tanaka, N., Ricci, R., Ishihara, T., et al. (2005) · Nature Medicine · doi:10.1038/nm1335 · Cited by 414 · see citing works
Interleukin-6 ( IL-6 ) and the Prognosis of Abdominal Aortic Aneurysms
Jones, K. G., Brull, D. J., Brown, L. C., Sian, M., Greenhalgh, R. M., Humphries, S. E., & Powell, J. T. (2001) · Circulation · doi:10.1161/01.cir.103.18.2260 · Cited by 369 · see citing works
Risk Factors for Abdominal Aortic Aneurysms in Older Adults Enrolled in the Cardiovascular Health Study
Alcorn, H. G., Wolfson, S. K., Sutton‐Tyrrell, K., Kuller, L. H., & O’Leary, D. H. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.8.963 · Cited by 337 · see citing works
Use of doxycycline to decrease the growth rate of abdominal aortic aneurysms: A randomized, double-blind, placebo-controlled pilot study
Mosorin, M., Juvonen, J., Biancari, F., Satta, J., Surcel, H., Leinonen, M., Saikku, P., & Juvonen, T. S. (2001) · Journal of Vascular Surgery · doi:10.1067/mva.2001.117891 · Cited by 328 · see citing works
Doxycycline inhibition of aneurysmal degeneration in an elastase-induced rat model of abdominal aortic aneurysm: Preservation of aortic elastin associated with suppressed production of 92 kD gelatinase
Petrinec, D., Liao, S., Holmes, D. R., et al. (1996) · Journal of Vascular Surgery · doi:10.1016/s0741-5214(96)70279-3 · Cited by 326 · see citing works
Aneurysms of the Abdominal Aorta in Older Adults
Pleumeekers, H. J. C. M., Hoes, A. W., van der Does, E., van Urk, H., Albert Hofman, D., de Jong, P. T. V. M., & Grobbee, D. E. (1995) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117596 · Cited by 315 · see citing works
Epidemiology of aortic aneurysm in the United States
Gillum, R. F. (1995) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(95)00045-3 · Cited by 310 · see citing works
Differential Effects of Doxycycline, a Broad-Spectrum Matrix Metalloproteinase Inhibitor, on Angiotensin II–Induced Atherosclerosis and Abdominal Aortic Aneurysms
Manning, M. W., Cassis, L. A., & Daugherty, A. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000058404.92759.32 · Cited by 305 · see citing works
Self-citation
Variability in measurement of abdominal aortic aneurysms
Lederle, F. A., Wilson, S. E., Johnson, G. R., Reinke, D. B., Littooy, F. N., Acher, C. W., Messina, L. M., Ballard, D., & Ansel, H. J. (1995) · Journal of Vascular Surgery · doi:10.1016/s0741-5214(95)70222-9 · Cited by 277 · see citing works
Statins are Associated with a Reduced Infrarenal Abdominal Aortic Aneurysm Growth
Schouten, O., van Laanen, J. H. H., Boersma, E. H., Vidaković, R., Feringa, H. H. H., Dunkelgrün, M., Bax, J. J., de Koning, J. J., van Urk, H., & Poldermans, D. (2006) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2005.12.024 · Cited by 261 · see citing works
Detection of Chlamydia pneumoniae but not Helicobacter pylori in atherosclerotic plaques of aortic aneurysms
Blasi, F., Denti, F., Erba, M., et al. (1996) · Journal of Clinical Microbiology · doi:10.1128/jcm.34.11.2766-2769.1996 · Cited by 251 · see citing works
The association between cigarette smoking and abdominal aortic aneurysms
Wilmink, T. B. M., Quick, C. R. G., & Day, N. (1999) · Journal of Vascular Surgery · doi:10.1016/s0741-5214(99)70049-2 · Cited by 234 · see citing works
Smokers’ relative risk for aortic aneurysm compared with other smoking-related diseases: a systematic review
Lederle, F. A., Nelson, D. B., & Joseph, A. M. (2003) · Journal of Vascular Surgery · doi:10.1016/s0741-5214(03)00136-8 · Cited by 231 · see citing works
Propranolol for small abdominal aortic aneurysms: Results of a randomized trial
The Propranolol Aneurysm Trial Investigators (2002) · Journal of Vascular Surgery · doi:10.1067/mva.2002.121308 · Cited by 231 · see citing works
Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells
Liu, J., Sukhova, G. K., Yang, J.-T., Sun, J., Ma, L., An, R., Xu, W.-H., Fu, H., Dolganov, G., Hu, C., et al. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.05.012 · Cited by 223 · see citing works
Risk factors associated with abdominal aortic aneurysm: A population-based study with historical and current data
Wanhainen, A., Bergqvist, D., Boman, K., Nilsson, T. K., Rutegård, M., & Björck, M. (2005) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2005.01.002 · Cited by 195 · see citing works
Pharmacologic suppression of experimental abdominal aortic aneurysms: A comparison of doxycycline and four chemically modified tetracyclines
Curci, J. A., Petrinec, D., Liao, S., Golub, L. M., & Thompson, R. W. (1998) · Journal of Vascular Surgery · doi:10.1016/s0741-5214(98)70035-7 · Cited by 189 · see citing works
Gender Differences in Experimental Aortic Aneurysm Formation
Ailawadi, G., Eliason, J. L., Roelofs, K. J., et al. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000143386.26399.84 · Cited by 184 · see citing works
Inhibition of Prostaglandin E2Synthesis in Abdominal Aortic Aneurysms
Walton, L. J., Franklin, I. J., Bayston, T. A., et al. (1999) · Circulation · doi:10.1161/01.cir.100.1.48 · Cited by 183 · see citing works
Randomized double-blind controlled trial of roxithromycin for prevention of abdominal aortic aneurysm expansion
Vammen, S., Lindholt, J. S., Østergaard, L. J., et al. (2001) · British journal of surgery · doi:10.1046/j.0007-1323.2001.01845.x · Cited by 175 · see citing works
Vitamin E Inhibits Abdominal Aortic Aneurysm Formation in Angiotensin II–Infused Apolipoprotein E–Deficient Mice
Gavrila, D., Li, W. G., McCormick, M. L., Thomas, M., Daugherty, A., Cassis, L. A., Miller, F. J., Oberley, L. W., Dellsperger, K. C., & Weintraub, N. L. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000172631.50972.0f · Cited by 172 · see citing works
Self-citation
Treatment With Simvastatin Suppresses the Development of Experimental Abdominal Aortic Aneurysms in Normal and Hypercholesterolemic Mice
Steinmetz, E. F., Buckley, C., Shames, M. L., Ennis, T. L., VanVickle-Chavez, S. J., Mao, D., Goeddel, L. A., Hawkins, C. J., & Thompson, R. W. (2005) · Annals of Surgery · doi:10.1097/01.sla.0000150258.36236.e0 · Cited by 169 · see citing works
Suppression of experimental abdominal aortic aneurysms in the rat by treatment with angiotensin-converting enzyme inhibitors
Liao, S., Miralles, M., Kelley, B. J., Curci, J. A., Borhani, M., & Thompson, R. W. (2001) · Journal of Vascular Surgery · doi:10.1067/mva.2001.112810 · Cited by 158 · see citing works
Association of Osteoprotegerin With Human Abdominal Aortic Aneurysm Progression
Moran, C. S., McCann, M., Karan, M., Norman, P. E., Ketheesan, N., & Golledge, J. (2005) · Circulation · doi:10.1161/circulationaha.104.464727 · Cited by 158 · see citing works
Self-citation
Screening for abdominal aortic aneurysm: lessons from a population‐based study
Jamrozik, K. D., Norman, P. E., Spencer, C. A., Parsons, R. W., Tuohy, R., MLawrence‐Brown, M., & Dickinson, J. A. (2000) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2000.tb125684.x · Cited by 157 · see citing works
Self-citation
The Plasma Level of Matrix Metalloproteinase 9 may Predict the Natural History of Small Abdominal Aortic Aneurysms. A Preliminary Study
Lindholt, J. S., Vammen, S., Fasting, H., et al. (2000) · European Journal of Vascular and Endovascular Surgery · doi:10.1053/ejvs.2000.1151 · Cited by 152 · see citing works
Smoking, atherosclerosis and risk of abdominal aortic aneurysm
Lee, A. J., Fowkes, F. G. R., Carson, M., Leng, G. C., & Allan, P. L. (1997) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a015314 · Cited by 138 · see citing works
Genome Scan for Familial Abdominal Aortic Aneurysm Using Sex and Family History as Covariates Suggests Genetic Heterogeneity and Identifies Linkage to Chromosome 19q13
Shibamura, H., Olson, J. M., Keulen, C. V. V.-V., et al. (2004) · Circulation · doi:10.1161/01.cir.0000127857.77161.a1 · Cited by 137 · see citing works
Selective Cyclooxygenase-2 Inhibition With Celecoxib Decreases Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice
King, V. L., Trivedi, D. B., Gitlin, J. M., et al. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000216119.79008.ac · Cited by 137 · see citing works
Plasma Levels of Metalloproteinases-3 and -9 as Markers of Successful Abdominal Aortic Aneurysm Exclusion After Endovascular Graft Treatment
Sangiorgi, G., Daverio, R., Mauriello, A., et al. (2001) · Circulation · doi:10.1161/hc37t1.094596 · Cited by 135 · see citing works
Fasudil, a Rho-Kinase Inhibitor, Attenuates Angiotensin II–Induced Abdominal Aortic Aneurysm in Apolipoprotein E–Deficient Mice by Inhibiting Apoptosis and Proteolysis
Wang, Y., Martin-McNulty, B., da Cunha, V., et al. (2005) · Circulation · doi:10.1161/01.cir.0000163544.17221.be · Cited by 131 · see citing works
The matrix metalloproteinase inhibitor BB-94 limits expansion of experimental abdominal aortic aneurysms
Bigatel, D. A., Elmore, J. R., Carey, D. J., Cizmeci-Smith, G., Franklin, D. P., & Youkey, J. R. (1999) · Journal of Vascular Surgery · doi:10.1016/s0741-5214(99)70354-x · Cited by 126 · see citing works
C-Reactive Protein Levels and the Expansion of Screen-Detected Abdominal Aortic Aneurysms in Men
Norman, P. E., Spencer, C. A., Lawrence‐Brown, M. M. D., & Jamrozik, K. D. (2004) · Circulation · doi:10.1161/01.cir.0000138746.14425.00 · Cited by 125 · see citing works
Self-citation
Smoking, but not Lipids, Lipoprotein (a) and Antibodies Against Oxidised LDL, is Correlated to the Expansion of Abdominal Aortic Aneurysms
Lindholt, J. S., Heegaard, N. H. H., Vammen, S., et al. (2001) · European Journal of Vascular and Endovascular Surgery · doi:10.1053/ejvs.2000.1262 · Cited by 122 · see citing works
Simvastatin suppresses experimental aortic aneurysm expansion
Kalyanasundaram, A., Elmore, J. R., Manazer, J. R., Golden, A. M., Franklin, D. P., Galt, S. W., Zakhary, E. M., & Carey, D. J. (2006) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2005.08.007 · Cited by 121 · see citing works
Functional matrix metalloproteinase-9 polymorphism (C-1562T) associated with abdominal aortic aneurysm
Jones, G. T., Phillips, V. L., Harris, E. L., et al. (2003) · Journal of Vascular Surgery · doi:10.1016/s0741-5214(03)01027-9 · Cited by 120 · see citing works
Familial abdominal aortic aneurysms: Collection of 233 multiplex families
Kuivaniemi, H., Shibamura, H., Arthur, C., Berguer, R., Cole, C. W., Juvonen, T. S., Kline, R. A., Limet, R., MacKean, G., Norrgård, Ö., et al. (2003) · Journal of Vascular Surgery · doi:10.1067/mva.2003.71 · Cited by 120 · see citing works
Ultrasonographic screening for abdominal aortic aneurysm in an urban community
Smith, F. C. T., Grimshaw, G. M., Paterson, I., et al. (1993) · British journal of surgery · doi:10.1002/bjs.1800801117 · Cited by 120 · see citing works
Genetic analysis of polymorphisms in biologically relevant candidate genes in patients with abdominal aortic aneurysms
Ogata, T., Shibamura, H., Tromp, G. C., Sinha, M., Goddard, K. A. B., Sakalihasan, N., Limet, R., MacKean, G. L., Arthur, C., Sueda, T., et al. (2005) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2005.02.020 · Cited by 117 · see citing works
Screening for abdominal aortic aneurysms and associated risk factors in a general population
Simoni, G. A., Pastorino, C., Perrone, R., et al. (1995) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/s1078-5884(05)80113-3 · Cited by 114 · see citing works
Familial Occurrence of Abdominal Aortic Aneurysm
Salo, J., Soisalon-Soininen, S., Bondestam, S., et al. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-8-199904200-00003 · Cited by 112 · see citing works
Simultaneous analysis of 1176 gene products in normal human aorta and abdominal aortic aneurysms using a membrane-based complementary DNA expression array
Tung, W. S., Lee, J. K., & Thompson, R. W. (2001) · Journal of Vascular Surgery · doi:10.1067/mva.2001.113310 · Cited by 106 · see citing works
Heme oxygenase-1 gene promoter polymorphism is associated with abdominal aortic aneurysm
Schillinger, M., Exner, M., Mlekusch, W., et al. (2002) · Thrombosis Research · doi:10.1016/s0049-3848(02)00100-7 · Cited by 105 · see citing works
17β-Estradiol Attenuates Development of Angiotensin II–Induced Aortic Abdominal Aneurysm in Apolipoprotein E–Deficient Mice
Martin-McNulty, B., Tham, D. M., da Cunha, V., Ho, J. J., Wilson, D. W., Rutledge, J. C., Deng, G. G., Vergona, R. A., Sullivan, M. E., & Wang, Y.-X. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000085842.20866.6a · Cited by 101 · see citing works
Comparison of surveillance vs Aortic Endografting for Small Aneurysm Repair (CAESAR) Trial: Study Design and Progress
Collaborators, C. T. (2005) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2005.05.043 · Cited by 101 · see citing works
Cystatin C deficiency is associated with the progression of small abdominal aortic aneurysms
Lindholt, J. S., Erlandsen, E. J., & Henneberg, E. W. (2001) · British journal of surgery · doi:10.1046/j.0007-1323.2001.01911.x · Cited by 100 · see citing works
HMG-CoA Reductase Inhibitors (Statins) Decrease MMP-3 and MMP-9 Concentrations in Abdominal Aortic Aneurysms
Wilson, W. R., Evans, J., Bell, P. R. F., & THOMPSON, M. M. (2005) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2005.02.044 · Cited by 96 · see citing works
Influence of Hypercholesterolemia and Adventitial Inflammation on the Development of Aortic Aneurysm in Rabbits
Freestone, T., Turner, R. J., Higman, D. J., Lever, M. J., & Powell, J. T. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.1.10 · Cited by 96 · see citing works
Persistent increase in the incidence of abdominal aortic aneurysm in Scotland, 1981–2000
Best, V., Price, J., & Fowkes, F. (2003) · British Journal of Surgery · doi:10.1002/bjs.4342 · Cited by 93 · see citing works
Differential gene expression in human abdominal aorta: Aneurysmal versus occlusive disease
Armstrong, P. J., Johanning, J. M., Calton, W. C., et al. (2002) · Journal of Vascular Surgery · doi:10.1067/mva.2002.121071 · Cited by 92 · see citing works
Expansion rates and outcomes for the 3.0-cm to the 3.9-cm infrarenal abdominal aortic aneurysm
Santilli, S. M., Littooy, F. N., Cambria, R. A., et al. (2002) · Journal of Vascular Surgery · doi:10.1067/mva.2002.121572 · Cited by 90 · see citing works
Indomethacin inhibits expansion of experimental aortic aneurysms via inhibition of the cox2 isoform of cyclooxygenase
Miralles, M., Wester, W., Sicard, G. A., et al. (1999) · Journal of Vascular Surgery · doi:10.1016/s0741-5214(99)70216-8 · Cited by 90 · see citing works
Rapamycin suppresses experimental aortic aneurysm growth
Lawrence, D. M., Singh, R. S., Franklin, D. P., Carey, D. J., & Elmore, J. R. (2004) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2004.05.020 · Cited by 90 · see citing works
Inhibition of inducible nitric oxide synthase limits nitric oxide production and experimental aneurysm expansion
Johanning, J. M., Franklin, D. P., Han, D. C., Carey, D. J., & Elmore, J. R. (2001) · Journal of Vascular Surgery · doi:10.1067/mva.2001.111805 · Cited by 84 · see citing works
Suppression of experimental abdominal aortic aneurysms by systemic treatment with a hydroxamate-based matrix metalloproteinase inhibitor (RS 132908)
Moore, G. H., Liao, S., Curci, J. A., STARCHER, B. C., Martin, R. L., Hendricks, R. T., Chen, J., & Thompson, R. W. (1999) · Journal of Vascular Surgery · doi:10.1016/s0741-5214(99)70281-8 · Cited by 83 · see citing works
Indicators of infection with Chlamydia pneumoniae are associated with expansion of abdominal aortic aneurysms
Lindholt, J. S., Ashton, H. A., & Scott, R. A. P. (2001) · Journal of Vascular Surgery · doi:10.1067/mva.2001.115816 · Cited by 76 · see citing works
High levels of homocysteine, lipoprotein (a) and plasminogen activator inhibitor-1 are present in patients with abdominal aortic aneurysm
Marcucci, R., Giusti, B., Pratesi, G., et al. (2005) · Thrombosis and Haemostasis · doi:10.1160/th05-06-0431 · Cited by 74 · see citing works
LDL Cholesterol is Associated with Small Abdominal Aortic Aneurysms
Hobbs, S. D., Claridge, M., Quick, C. R. G., Day, N., Bradbury, A. W., & Wilmink, A. B. M. (2003) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/s1078-5884(03)00412-x · Cited by 70 · see citing works
Relationships between activators and inhibitors of plasminogen, and the progression of small abdominal aortic aneurysms
Lindholt, J. S., Jørgensen, B., Shi, G.-P., et al. (2003) · European Journal of Vascular and Endovascular Surgery · doi:10.1053/ejvs.2002.1872 · Cited by 70 · see citing works
Plasma levels of plasmin-antiplasmin-complexes are predictive for small abdominal aortic aneurysms expanding to operation-recommendable sizes
Lindholt, J. S., Jørgensen, B., Fasting, H., et al. (2001) · Journal of Vascular Surgery · doi:10.1067/mva.2001.119040 · Cited by 69 · see citing works
Macrophage migration inhibitory factor is associated with aneurysmal expansion
Pan, J., Lindholt, J. S., Sukhova, G. K., et al. (2003) · Journal of Vascular Surgery · doi:10.1067/mva.2003.74 · Cited by 68 · see citing works
Tamoxifen up-regulates catalase production, inhibits vessel wall neutrophil infiltration, and attenuates development of experimental abdominal aortic aneurysms
Grigoryants, V., Hannawa, K. K., Pearce, C. G., et al. (2005) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2004.09.033 · Cited by 67 · see citing works
Chlamydia pneumoniae in Abdominal Aortic Aneurysms
Meijer, A., van der Vliet, J. A., Roholl, P. J. M., et al. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.11.2680 · Cited by 67 · see citing works
Suppression of experimental abdominal aortic aneurysms in mice by treatment with pyrrolidine dithiocarbamate, an antioxidant inhibitor of nuclear factor-κB
Parodi, F. E., Mao, D., Ennis, T. L., Bartoli, M. A., & Thompson, R. W. (2005) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2004.12.030 · Cited by 65 · see citing works
Serum-elastin-peptides as a predictor of expansion of small abdominal aortic aneurysms
Lindholt, J. S., Heickendorff, L., Henneberg, E. W., et al. (1997) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/s1078-5884(97)80219-5 · Cited by 63 · see citing works
Association of the 4G/5G polymorphism in the promoter region of plasminogen activator inhibitor-1 with abdominal aortic aneurysms
Rossaak, J. I., van Rij, A. M., Jones, G. T., et al. (2000) · Journal of Vascular Surgery · doi:10.1067/mva.2000.104589 · Cited by 61 · see citing works
ACE DD Genotype: A Predisposing Factor for Abdominal Aortic Aneurysm
Fatini, C., Pratesi, G., Sofi, F., Gensini, F., Sticchi, E., Lari, B., Pulli, R., Dorigo, W., Azas, L., Pratesi, C., et al. (2005) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2004.12.018 · Cited by 60 · see citing works
Expansion of aortic aneurysms is reduced by propranolol in a hypertensive rat model
Slaiby, J. M., Ricci, M. A., Gadowski, G. R., Hendley, E. D., & PILCHER, D. B. (1994) · Journal of Vascular Surgery · doi:10.1016/0741-5214(94)90004-3 · Cited by 56 · see citing works
Are antihypertensive drugs associated with abdominal aortic aneurysms?
Wilmink, A. B. M. (2002) · Journal of Vascular Surgery · doi:10.1016/s0741-5214(02)00129-5 · Cited by 56 · see citing works
Immunoglobulin A antibodies against Chlamydia pneumoniae are associated with expansion of abdominal aortic aneurysm
Lindholt, J. S., Juul, S., Vammen, S., et al. (1999) · British journal of surgery · doi:10.1046/j.1365-2168.1999.01126.x · Cited by 55 · see citing works
Co-Morbidity in Patients with Abdominal Aortic Aneurysm
Kanagasabay, R. R., Gajraj, H., Pointon, L. J., et al. (1996) · Journal of Medical Screening · doi:10.1177/096914139600300410 · Cited by 52 · see citing works
Genetic similarity in inflammatory and degenerative abdominal aortic aneurysms: A study of human leukocyte antigen class II disease risk genes
Rasmussen, T. E., Hallett, J. W., Schulte, S., et al. (2001) · Journal of Vascular Surgery · doi:10.1067/mva.2001.115603 · Cited by 52 · see citing works
Ultrasonographic screening for abdominal aortic aneurysm.
Cd, K., Kullmann, G., Kvernebo, K., et al. (1992) · PubMed · Cited by 52 · see citing works
Genetic risk factor characterizes abdominal aortic aneurysm from arterial occlusive disease in human beings: CCR5 Δ32 deletion
Ghilardi, G., Biondi, M. L., Battaglioli, L., Zambon, A., Guagnellini, E., & Scorza, R. (2004) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2004.08.014 · Cited by 51 · see citing works
Propranolol delays the formation of aneurysms in the male blotchy mouse
Brophy, C. M., Tilson, J. E., & Tilson, M. D. (1988) · Journal of Surgical Research · doi:10.1016/0022-4804(88)90101-1 · Cited by 50 · see citing works
Abdominal Aortic Aneurysm in Normotensive Patients: Association with Angiotensin-converting Enzyme Gene Polymorphism
Pola, R., Gaetani, E., Santoliquido, A., et al. (2001) · European Journal of Vascular and Endovascular Surgery · doi:10.1053/ejvs.2001.1339 · Cited by 49 · see citing works
Are antihypertensive drugs associated with abdominal aortic aneurysms?
Wilmink, A. B. M., Vassiliadi Dimitra, A., Hubbard, C. S. F., et al. (2002) · Journal of Vascular Surgery · doi:10.1067/mva.2002.126550 · Cited by 49 · see citing works
Five-year Results of Elastin and Collagen Markers as Predictive Tools in the Management of Small Abdominal Aortic Aneurysms
Lindholt, J. S., Heickendorff, L., Vammen, S., et al. (2001) · European Journal of Vascular and Endovascular Surgery · doi:10.1053/ejvs.2001.1329 · Cited by 47 · see citing works
Uptake of tetracycline by aortic aneurysm wall and its effect on inflammation and proteolysis
Franklin, I. J., Harley, S. L., Greenhalgh, R. M., et al. (1999) · British journal of surgery · doi:10.1046/j.1365-2168.1999.01137.x · Cited by 46 · see citing works
Aminoterminal Propeptide of Type III Procollagen and Matrix Metalloproteinases-2 and -9 Failed to Serve as Serum Markers for Abdominal Aortic Aneurysm
Eugster, T., Huber, A., Obeid, T. E., et al. (2005) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2004.12.007 · Cited by 46 · see citing works
Genetic approach to the role of cysteine proteases in the expansion of abdominal aortic aneurysms
Eriksson, P. O., Jones, K. G., Brown, L. C., et al. (2004) · British journal of surgery · doi:10.1002/bjs.4364 · Cited by 44 · see citing works
The role of cytokine gene polymorphisms in the pathogenesis of abdominal aortic aneurysms: A case-control study
Bown, M. J., Burton, P. R., Horsburgh, T., Nicholson, M. L., BELL, P. R. F., & Sayers, R. D. (2003) · Journal of Vascular Surgery · doi:10.1067/mva.2003.174 · Cited by 43 · see citing works
eNOS G894T polymorphism as a mild predisposing factor for abdominal aortic aneurysm
Fatini, C., Sofi, F., Sticchi, E., et al. (2005) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2005.05.044 · Cited by 42 · see citing works
Hospital Based Screening of 65–73 Year Old Men for Abdominal Aortic Aneurysms in the County of Viborg, Denmark
Lindholt, J. S., Henneberg, E. W., Fasting, H., et al. (1996) · Journal of Medical Screening · doi:10.1177/096914139600300111 · Cited by 42 · see citing works
Increased risk of the abdominal aortic aneurysm in carriers of the MTHFR 677T allele.
Strauss, E., Waliszewski, K., Gabriel, M., et al. (2003) · PubMed · Cited by 40 · see citing works
The Influence of Indomethacin on the Metabolism and Cytokine Secretion of Human Aneurysmal Aorta
Franklin, I. J., Walton, L. J., Greenhalgh, R. M., et al. (1999) · European Journal of Vascular and Endovascular Surgery · doi:10.1053/ejvs.1999.0820 · Cited by 37 · see citing works
Lack of Association Between Serum Immunoreactivity and Chlamydia pneumoniae Detection in the Human Aortic Wall
Porqueddu, M., Spirito, R., Parolari, A., Zanobini, M., Pompilio, G., Polvani, G., Alamanni, F., Stangalini, D., Tremoli, E., & Biglioli, P. (2002) · Circulation · doi:10.1161/01.cir.0000041626.38101.db · Cited by 34 · see citing works
Deletion Polymorphism in the Gene for Angiotensin-converting Enzyme is not a Risk Factor Predisposing to Abdominal Aortic Aneurysm
Hamano, K., Ohishi, M., Ueda, M., et al. (1999) · European Journal of Vascular and Endovascular Surgery · doi:10.1053/ejvs.1999.0873 · Cited by 34 · see citing works
The Methylenetetrahydrofolate Reductase C677T Polymorphism Does Not Associate with Susceptibility to Abdominal Aortic Aneurysm
Jones, G. T., Harris, E. L., Phillips, L. V., et al. (2005) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2005.02.047 · Cited by 30 · see citing works
Serum Elastin Peptides in the Preoperative Evaluation of Abdominal Aortic Aneurysms
Lindholt, J. S., Ashton, H. A., Heickendorff, L., et al. (2001) · European Journal of Vascular and Endovascular Surgery · doi:10.1053/ejvs.2001.1516 · Cited by 29 · see citing works
Allelic genes involved in artery compliance and susceptibility to sporadic abdominal aortic aneurysm
Massart, F., Marini, F., Menegato, A., et al. (2004) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.10.010 · Cited by 28 · see citing works
Suppression of Experimental Aortic Aneurysms: Comparison of Inducible Nitric Oxide Synthase and Cyclooxygenase Inhibitors
Armstrong, P. J., Franklin, D. P., Carey, D. J., et al. (2005) · Annals of Vascular Surgery · doi:10.1007/s10016-004-0174-7 · Cited by 28 · see citing works
The Relation between Chlamydia pneumoniae Infection and Abdominal Aortic Aneurysm: Case-Control Study
Blanchard, J., Armenian, H. K., Peeling, R. W. W., et al. (2000) · Clinical Infectious Diseases · doi:10.1086/313806 · Cited by 28 · see citing works
Effects of Hypertension and Propranolol upon Aneurysm Expansion in the Anidjar/Dobrin Aneurysm Modela
Ricci, M. A., Slaiby, J. M., Gadowski, G. R., et al. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb33301.x · Cited by 27 · see citing works
The Association Between Connective Tissue Laxity and the Risk of an Abdominal Aortic Aneurysm
Wilmink, A., Quick, C. R. G., Hubbard, C. S., & Day, N. E. (2000) · European Journal of Vascular and Endovascular Surgery · doi:10.1053/ejvs.2000.1180 · Cited by 23 · see citing works
Abdominal Aortic Aneurysm Is Associated With High Serum Levels of Tenascin-X and Decreased Aneurysmal Tissue Tenascin-X
Zweers, M., Peeters, A. C., Graafsma, S., Kranendonk, S., van der Vliet, J. A., den Heijer, M., & Schalkwijk, J. (2006) · Circulation · doi:10.1161/circulationaha.104.513820 · Cited by 21 · see citing works
Selecting subjects for ultrasonographic screening for aneurysms of the abdominal aorta: four different strategies
Pleumeekers, H. J. C. M., Hoes, A. W., Hofman, A., et al. (1999) · International Journal of Epidemiology · doi:10.1093/ije/28.4.682 · Cited by 18 · see citing works
Evaluation of Enzymes Involved in Proteoglycan Degradation in the Wall of Abdominal Aortic Aneurysms
Kowalewski, R., Sobolewski, K., Małkowski, A., et al. (2005) · Journal of Vascular Research · doi:10.1159/000089790 · Cited by 17 · see citing works
Apolipoprotein E genotype is associated with differential expansion rates of small abdominal aortic aneurysms
Gerdes, L. U., Lindholt, J. S., Vammen, S., Henneberg, E. W., & Fasting, H. (2000) · British journal of surgery · doi:10.1046/j.1365-2168.2000.01486.x · Cited by 16 · see citing works
Non-steroidal anti-inflammatory drugs to treat abdominal aortic aneurysm
Franklin, I. J., Walton, L. J., Brown, L. C., et al. (1999) · British journal of surgery · doi:10.1046/j.1365-2168.1999.0707b.x · Cited by 13 · see citing works

Flagged first, then by citations

Sorted by citations

2019 ESC/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk
Mach, F., Baigent, C., Catapano, A. L., Koskinas, K. C., Casula, M., Badimon, L., Chapman, M. J., De Backer, G. G., Delgado, V., Ference, B. A., et al. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.08.014 · Cited by 4,854 · see citing works
2016 ESC/EAS Guidelines for the Management of Dyslipidaemias
Catapano, A. L., Graham, I., De Backer, G., Wiklund, O., Chapman, M. J., Drexel, H., Hoes, A. W., Jennings, C. S., Landmesser, U., Pedersen, T. R., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw272 · Cited by 3,162 · see citing works
2016 ESC/EAS Guidelines for the Management of Dyslipidaemias
Catapano, A. L., Graham, I., De Backer, G., Wiklund, O., Chapman, M. J., Drexel, H., Hoes, A. W., Jennings, C. S., Landmesser, U., Pedersen, T. R., et al. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.08.018 · Cited by 1,582 · see citing works
ESC/EAS Guidelines for the management of dyslipidaemias
Catapano, A. L., Reiner, Ž., De Backer, G., Graham, I., Taskinen, M.-R., Wiklund, O., Agewall, S., Alegria, E., Chapman, M. J., Durrington, P., et al. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.06.028 · Cited by 706 · see citing works

Natural History of Chiari Malformations
Maher, C. O. (2020) · Springer eBooks · doi:10.1007/978-3-030-44862-2_22 · Cited by 1 · see citing works
Unnatural natural history of Duchenne muscular dystrophy
Dubowitz, V. (2015) · Neuromuscular Disorders · doi:10.1016/j.nmd.2015.11.005 · Cited by 4 · see citing works
DEPARTMENT OF LIBRARY SERVICES, BRITISH MUSEUM (NATURAL HISTORY), 1986. Annual bibliography of the history of natural history, Volume 2—publications of 1983. British Museum (Natural History). Pp iv + 106.
Mabberley, D. J. (1988) · Archives of Natural History · doi:10.3366/anh.1988.15.1.119
Natural History of Untreated Benign Prostatic Hyperplasia
Barry, M. J. (1995) · Springer eBooks · doi:10.1007/978-3-642-78826-0_12 · Cited by 2 · see citing works
THACKRAY, J. C. A guide to the official archives of The Natural History Museum, London. Society for the History of Natural History on behalf of The Natural History Museum, London: 1998. Pp xix, 174. Price £25.00 (US$42); price to SHNH members £18.75 (US$32). ISBN 0-901-843-08-3
Davis, P. S. (2000) · Archives of Natural History · doi:10.3366/anh.2000.27.1.152

Authors: Golledge, J., Muller, J., Daugherty, A., & Norman, P.
Affiliations: University of Kentucky (US)
ORCID: Golledge, Jonathan
Daugherty, Alan
Venue: Arteriosclerosis Thrombosis and Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2006-12
Volume: 26
Issue: 12
Pages: 2605-2613
ISSN: 1079-5642 (ISSN-L)
1524-4636
DOI: 10.1161/01.atv.0000245819.32762.cb
OpenAlex: W2164258641
Cited by: 625
References: 116
Citations by year: 2026: 23 · 2025: 22 · 2024: 31 · 2023: 31 · 2022: 42 · 2021: 37 · 2020: 27 · 2019: 34 · 2018: 35 · 2017: 35 · 2016: 40 · 2015: 32 · 2014: 35 · 2013: 37 · 2012: 34
FWCI: 3.49
Type: journal article
Language: en
Open access: closed
Locations: Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
PubMed (publishedVersion)
ResearchOnline at James Cook University (James Cook University) (submittedVersion)
UWA Profiles and Research Repository (UWA) (submittedVersion)
Funders: National Institutes of Health (5r01hl080010-05)
National Heart, Lung, and Blood Institute (R01 HL 080010-01)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Aortic aneurysm repair treatments
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Aortic Disease and Treatment Approaches
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
Keywords: abdominal aortic aneurysm, risk factors, genetic association, serum biomarkers, smoking cessation, cholesterol management, blood pressure control, aneurysm progression, natural history (disease), endovascular repair, open surgical repair, statins, macrolides, anti-inflammatory therapy, proteolysis, pharmacotherapy
MeSH terms: Animals, Humans, Inflammation, Risk Factors, Smoking Cessation, Aortic Aneurysm, Abdominal, Macrolides, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Angiotensin II Type 1 Receptor Blockers

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Abdominal Aortic Aneurysm: Pathogenesis and Implications for Management

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks