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Cited by 12Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular HealthLipid metabolism and disorders

Continuous infusion of interleukin-1 beta in rats induces a profound fall in plasma levels of cholesterol and triglycerides.

Hermus, A R, Sweep, C G, Demacker, P N, van der Meer, M J, Kloppenborg, P W, van der Meer, J W·1992·Arteriosclerosis and Thrombosis: A Journal of Vascular Biology
DOI 10.1161/01.atv.12.9.1036
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Abstract

During infectious diseases, striking alterations in plasma concentrations of cholesterol (hypocholesterolemia) and triglycerides (hypertriglyceridemia) may occur. It has been suggested that interleukin-1 is a mediator of these alterations. We studied the effects of continuous administration of recombinant human interleukin-1 beta (rhIL-1 beta) on plasma levels of cholesterol and triglycerides. A total of 42 rats were equipped with minipumps loaded with either rhIL-1 beta (delivery rate of 0.5, 2.0, or 4.0 micrograms/day i.p. for 1 week) or saline. After 1 day of treatment with rhIL-1 beta, plasma cholesterol levels had not changed. On day 2 a remarkable decrease of plasma cholesterol levels was observed in rats treated with 2.0 micrograms rhIL-1 beta/day (1.49 +/- 0.13 versus 2.23 +/- 0.08 mmol/l, p less than 0.005; rhIL-1 beta versus saline) or 4.0 micrograms rhIL-1 beta/day (1.46 +/- 0.04 versus 2.18 +/- 0.04 mmol/l,p less than 0.0005). This decrease persisted until the end of the experiment and occurred in all major lipoprotein fractions. Triglycerides in plasma (and in very low density lipoprotein) decreased almost concomitantly with plasma cholesterol, although to a lesser degree. Infusion of 2.0 micrograms rhIL-1 beta/day did not affect either cholesterol esterification or total postheparin lipolytic activity in plasma. Long-term infusion with 4.0 micrograms rhIL-1 beta/day induced prolonged fever, whereas at the lower doses temperatures were elevated only the first 2 days. rhIL-1 beta at a dose of 2.0 and 4.0 micrograms/day induced a transient decrease of food intake and a suppression of body weight gain.(ABSTRACT TRUNCATED AT 250 WORDS)

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Crossref · 10.1161/01.atv.12.9.1036

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  • Chronic IL-1β administration in rats induces NTIS.

    “Like chronic IL-6 administration, chronic IL-1β administration in rats induces NTIS [55].”

    From An update on non-thyroidal illness syndrome (2021) · cites this paper as [55]

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Authors
Hermus, A. R., Sweep, C. G., Demacker, P. N., van der Meer, M. J., Kloppenborg, P. W., & van der Meer, J. W.
Affiliations
  • Radboud University Medical Center (NL)
  • Department of Medicine, Sint Radboud University Hospital, Nijmegen, The Netherlands.
ORCID
Hermus, A R
Venue
Arteriosclerosis and Thrombosis: A Journal of Vascular Biology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1992-09
Volume
12
Issue
9
Pages
1036-1043
ISSN
1049-8834 (ISSN-L)
DOI
10.1161/01.atv.12.9.1036
OpenAlex
W2128126561
Cited by
12
References
42
Citations by year
2020: 1 · 2018: 1 · 2017: 2
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Locations
  • Arteriosclerosis and Thrombosis A Journal of Vascular Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords
IL-1β, hypocholesterolemia, hypertriglyceridemia, serum cholesterol, plasma triglycerides, lipoproteins, VLDL, cholesterol esterification, lipolysis, fever, dietary intake, body weight
MeSH terms
Animals, Body Temperature, Cholesterol, Cholesterol Esters, Eating, Interleukin-1, Lipoprotein Lipase, Lipoproteins, Male, Rats, Inbred Strains, Recombinant Proteins, Triglycerides, Macrophage Colony-Stimulating Factor, Granulocyte-Macrophage Colony-Stimulating Factor, Rats

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