Apolipoprotein E Alleles and Risk of Coronary Disease: A Meta-analysis
Abstract
A meta-analysis was undertaken to assess the impact of apolipoprotein E (apo E) alleles (ε2, ε3, and ε4) on coronary disease in 14 published observational studies (9 clinical coronary disease and 5 coronary angiography). In comparison with ε3, the ε4 allele was associated with greater odds for coronary heart disease, and summary estimates of the odds ratios (ORs) and (95% confidence intervals) for both sexes combined were OR=0.98 (0.85-1.14) for ε2 and OR=1.26 (1.13-1.41) for ε4. Separate analyses for men and women showed similar associations. In angiographic studies the relative odds for significant coronary artery disease among both sexes combined was OR=0.76 (0.55-1.05) for ε2 and OR=1.11 (0.88-1.40) for ε4. The overall impression is that ε4 is associated with clinical and coronary disease and that results are similar in men and women.
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The ɛ4 allele has been associated with an increased risk of cardiovascular disease in a meta-analysis of studies up to 1996.
“the ɛ4 allele has been associated with an increased risk of cardiovascular disease in a meta-analysis of studies up to 1996 [ 43].”
From ApoE Plasma Levels and Risk of Cardiovascular Mortality in Old Age (2006) · cites this paper as [43]
The results of individual studies on the association of the ɛ2 allele and cardiovascular disease have been conflicting.
“The results of individual studies on the association of the ɛ2 allele and cardiovascular disease have been conflicting.”
From ApoE Plasma Levels and Risk of Cardiovascular Mortality in Old Age (2006) · cites this paper as [43]
Cites
Apolipoprotein E polymorphism and atherosclerosis.
Davignon, J., Gregg, R. E., & Sing, C. F. (1988) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.8.1.1 · Cited by 1,981 · see citing works
Apolipoprotein E alleles, dyslipidemia, and coronary heart disease. The Framingham Offspring Study
Wilson, P. W. F. (1994) · JAMA · doi:10.1001/jama.1994.03520210050031 · Cited by 468 · see citing works
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Davey Smith, G., & Ebrahim, S. (2003) · International Journal of Epidemiology · doi:10.1093/ije/dyg070 · Cited by 5,882 · see citing works
Casserly, I., & Topol, E. J. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15900-x · Cited by 560 · see citing works
Ott, A., Slooter, A., Hofman, A., van Harskamp, F., Witteman, J., Van Broeckhoven, C., van Duijn, C., & Breteler, M. (1998) · The Lancet · doi:10.1016/s0140-6736(97)07541-7 · Cited by 535 · see citing works
Meta-Analysis: Apolipoprotein E Genotypes and Risk for Coronary Heart Disease
Song, Y., Stampfer, M. J., & Liu, S. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-141-2-200407200-00013 · Cited by 528 · see citing works
Zareparsi, S., Buraczynska, M., Branham, K. E. H., Shah, S., Eng, D., Li, M., Pawar, H., Yashar, B. M., Moroi, S. E., Lichter, P. R., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi154 · Cited by 190 · see citing works
ApoE Plasma Levels and Risk of Cardiovascular Mortality in Old Age
Mooijaart, S. P., Berbée, J. F. P., van Heemst, D., Havekes, L. M., de Craen, A. J. M., Slagboom, P. E., Rensen, P. C. N., & Westendorp, R. G. J. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030176 · Cited by 129 · see citing works
Molecular and biochemical changes of the cardiovascular system due to smoking exposure
Armani, C., Landini Jr., L., & Leone, A. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209787846973 · Cited by 68 · see citing works
Gustavsson, J., Mehlig, K., Leander, K., Strandhagen, E., Björck, L., Thelle, D. S., Lissner, L., Blennow, K., Zetterberg, H., & Nyberg, F. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.10.011 · Cited by 41 · see citing works
- Authors
- Wilson, P. W. F., Schaefer, E. J., Larson, M. G., & Ordovas, J. M.
- Affiliations
- Boston University (US)
- the Framingham Heart Study, National Heart, Lung, and Blood Institute (P.W.F.W.) and Boston University (M.G.L.), Framingham, and Tufts USDA Nutrition Center, Boston (E.J.S., J.M.O.), Mass.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 1996-10
- Volume
- 16
- Issue
- 10
- Pages
- 1250-1255
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2070901692
- Cited by
- 539
- References
- 2
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 7 · 2023: 4 · 2022: 5 · 2021: 9 · 2020: 5 · 2019: 6 · 2018: 7 · 2017: 9 · 2016: 9 · 2015: 10 · 2014: 17 · 2013: 9 · 2012: 13
- FWCI
- 18.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
- Keywords
- apolipoprotein E, coronary artery disease, genetic risk factors, sex differences
- MeSH terms
- Adolescent, Adult, Alleles, Apolipoproteins E, Coronary Disease, Female, Humans, Male, Risk Factors
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