The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Dose-Response Relationship Between Ischemic Heart Disease Mortality and Long-term Arsenic Exposure
Abstract
Abstract The cardiovascular effects of inorganic arsenic have been documented, but the dose-response relationship between ischemic heart disease (ISHD) and long-term arsenic exposure remains to be elucidated. Mortality rates from ISHD among residents in 60 villages of the area in Taiwan with endemic arseniasis from 1973 through 1986 were analyzed to examine their association with arsenic concentration in drinking water. Based on 1 355 915 person-years and 217 ISHD deaths, the cumulative ISHD mortalities from birth to age 79 years were 3.4%, 3.5%, 4.7%, and 6.6%, respectively, for residents who lived in villages in which the median arsenic concentrations in drinking water were <0.1, 0.1 to 0.34, 0.35 to 0.59, and ≥0.6 mg/L. A cohort of 263 patients affected with blackfoot disease (BFD), a unique arsenic-related peripheral vascular disease, and 2293 non-BFD residents in the endemic area of arseniasis were recruited and followed up for an average period of 5.0 years. There was a monotonous biological gradient relationship between cumulative arsenic exposure through drinking artesian well water and ISHD mortality. The relative risks were 2.5, 4.0, and 6.5, respectively, for those who had a cumulative arsenic exposure of 0.1 to 9.9, 10.0 to 19.9, and ≥20.0 mg/L-years compared with those without the arsenic exposure after adjustment for age, sex, cigarette smoking, body mass index, serum cholesterol and triglyceride levels, and disease status for hypertension and diabetes through proportional-hazards regression analysis. BFD patients were found to have a significantly higher ISHD mortality than non-BFD residents, showing a multivariate-adjusted relative risk of 2.5 (95% CI, 1.1 to 5.4).
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Cites
International Agency for Research on Cancer
National Cancer Institute (2020) · Definitions · doi:10.32388/pfg7jq · Cited by 9,435
Cancer risks from arsenic in drinking water
Smith, A. H., Hopenhayn-Rich, C., Bates, M. N., Goeden, H. M., Hertz-Picciotto, I., Duggan, H. M., Wood, R., Kosnett, M. J., & Smith, M. T. (1992) · Environmental Health Perspectives · doi:10.1289/ehp.9297259 · Cited by 1,110
WU, M.-M., KUO, T.-L., HWANG, Y.-H., & CHEN, C.-J. (1989) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115439 · Cited by 648
Self-citationIncreased Prevalence of Hypertension and Long-term Arsenic Exposure
Chen, C.-J., Hsueh, Y.-M., Lai, M.-S., Shyu, M.-P., Chen, S.-Y., Wu, M.-M., Kuo, T.-L., & Tai, T.-Y. (1995) · Hypertension · doi:10.1161/01.hyp.25.1.53 · Cited by 450
Self-citationToward a Clearer Definition of Confounding
Weinberg, C. R. (1993) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116591 · Cited by 401
Ingested Inorganic Arsenic and Prevalence of Diabetes Mellitus
Lai, M.-S., Hsueh, Y.-M., Chen, C.-J., Shyu, M.-P., Chen, S.-Y., Kuo, T.-L., Wu, M.-M., & Tai, T.-Y. (1994) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117031 · Cited by 354
Self-citationChen, C. J., Wu, M. M., Lee, S. S., Wang, J. D., Cheng, S. H., & Wu, H. Y. (1988) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.8.5.452 · Cited by 280
Self-citationBorgoño, J. M., Vicent, P., Venturino, H., & Infante, A. (1977) · Environmental Health Perspectives · doi:10.1289/ehp.19-1637404 · Cited by 253
Arsenic exposure and mortality: a case-referent study from a Swedish copper smelter.
Axelson, O., Dahlgren, E., Jansson, C. D., & Rehnlund, S. O. (1978) · Occupational and Environmental Medicine · doi:10.1136/oem.35.1.8 · Cited by 225
Chronic arsenic toxicity from drinking tubewell water in rural West Bengal.
Mazumder, D. N. G., Chakraborty, A. K., Ghose, A., Gupta, J., Chakraborty, D. P., Dey, S. B., & Chattopadhyay, N. (1988) · Europe PMC (PubMed Central) · Cited by 209
Cited by
Spatial and Temporal Variations of Groundwater Arsenic in South and Southeast Asia
Fendorf, S., Michael, H. A., & van Geen, A. (2010) · Science · doi:10.1126/science.1172974 · Cited by 1,193
Chowdhury, R., Ramond, A., O’Keeffe, L. M., Shahzad, S., Kunutsor, S. K., Muka, T., Gregson, J., Willeit, P., Warnakula, S., Khan, H., et al. (2018) · BMJ · doi:10.1136/bmj.k3310 · Cited by 638
Chen, Y., Graziano, J. H., Parvez, F., Liu, M., Slavkovich, V., Kalra, T., Argos, M., Islam, T., Ahmed, A., Rakibuz-Zaman, M., et al. (2011) · BMJ · doi:10.1136/bmj.d2431 · Cited by 454
Mechanisms pertaining to arsenic toxicity
Kaur, T., Singh, A., & Goel, R. (2011) · Toxicology International · doi:10.4103/0971-6580.84258 · Cited by 326
Pathology related to chronic arsenic exposure.
Centeno, J. A., Mullick, F. G., Martinez, L., Page, N. P., Gibb, H., Longfellow, D., Thompson, C., & Ladich, E. R. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.02110s5883 · Cited by 304
Metadata
- Authors
- Chen, C.-J., Chiou, H.-Y., Chiang, M.-H., Lin, L.-J., & Tai, T.-Y.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 1996-04
- Volume
- 16
- Issue
- 4
- Pages
- 504-510
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2158327446
- Cited by
- 316
- References
- 22
- FWCI
- 6.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chen, C.-J., Chiou, H.-Y., Chiang, M.-H., Lin, L.-J., & Tai, T.-Y. (1996). Dose-Response Relationship Between Ischemic Heart Disease Mortality and Long-term Arsenic Exposure. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/01.atv.16.4.504
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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