The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Monocyte Chemoattractant Protein-1 Accelerates Atherosclerosis in Apolipoprotein E-Deficient Mice
Open accessAbstract
Abstract—The pro-inflammatory chemokine, monocyte chemoattractant protein-1 (MCP-1), plays a fundamental role in monocyte recruitment and has been implicated as a contributing factor to atherosclerosis. The predominant cell types within the vessel wall—endothelial cells, smooth muscle cells, and macrophages—all contribute to overexpression of MCP-1 in atherosclerotic tissue. In this report we assess the role of MCP-1 expression by leukocytes on lesion progression in a murine model susceptible to atherosclerosis. Bone marrow cells from mice overexpressing a murine MCP-1 transgene on a background of apoE-deficiency or from control mice were transplanted into irradiated apoE-knockout mice. After repopulation of apoE-knockout mice with bone marrow containing the MCP-1 transgene, macrophages expressing the MCP-1 transgene were found in several tissues, including the aorta. Qualitative assessment of atherosclerosis in these mice revealed increased lipid staining, a 3-fold (P<0.001) increase in the amount of oxidized lipid, and increased immunostaining for macrophage cell surface markers with anti-F4/80 and anti-CD11b antibodies. There were no differences in plasma lipids, plasma lipoprotein profiles, or body weight between the 2 groups. These results provide the first direct evidence that MCP-1 expression by leukocytes, predominately macrophages, increases the progression of atherosclerosis by increasing both macrophage numbers and oxidized lipid accumulation.
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Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man
Luchtefeld, M., Schunkert, H., Stoll, M., Selle, T., Lorier, R., Grote, K., Sagebiel, C., Jagavelu, K., Tietge, U. J. F., Assmus, U., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070120 · Cited by 69
Dysfunction of cholesterol sensor SCAP promotes inflammation activation in THP-1 macrophages
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Metadata
- Authors
- Aiello, R. J., Bourassa, P.-A. K., Lindsey, S., Weng, W., Natoli, E., Rollins, B. J., & Milos, P. M.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 1999-06
- Volume
- 19
- Issue
- 6
- Pages
- 1518-1525
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2052544509
- Cited by
- 466
- References
- 5
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- bronze
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