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Cited by 581

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

C-Reactive Protein in the Arterial Intima: Role of C-Reactive Protein Receptor–Dependent Monocyte Recruitment in Atherogenesis

Torzewski, Michael, Rist, Carsten, Mortensen, Richard F., Zwaka, Thomas P., Bienek, Magda, Waltenberger, Johannes, Koenig, Wolfgang, Schmitz, Gerd, Hombach, Vinzenz, Torzewski, Jan·2000·Arteriosclerosis, Thrombosis, and Vascular Biology

Abstract

Abstract —Infiltration of monocytes into the arterial wall is an early cellular event in atherogenesis. Recent evidence shows that C-reactive protein (CRP) is deposited in the arterial intima at sites of atherogenesis. In this study, we demonstrate that CRP deposition precedes the appearance of monocytes in early atherosclerotic lesions. CRP is chemotactic for freshly isolated human blood monocytes. A specific CRP receptor is demonstrated on monocytes in vitro as well as in vivo, and blockage of the receptor by use of a monoclonal anti-receptor antibody completely abolishes CRP-induced chemotaxis. CRP may play a major role in the recruitment of monocytes during atherogenesis.

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Crossref · 10.1161/01.atv.20.9.2094

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Metadata

Authors
Torzewski, M., Rist, C., Mortensen, R. F., Zwaka, T. P., Bienek, M., Waltenberger, J., Koenig, W., Schmitz, G., Hombach, V., & Torzewski, J.
Venue
Arteriosclerosis, Thrombosis, and Vascular Biology
Published
2000-09
Volume
20
Issue
9
Pages
2094-2099
ISSN
  • 1079-5642 (ISSN-L)
  • 1524-4636
OpenAlex
W2156744146
Cited by
581
References
2
FWCI
12.04
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: C-Reactive Protein in the Arterial Intima: Role of C-Reactive Protein Receptor–Dependent Monocyte Recruitment in Atherogenesis. https://app.cochat.ai/papers/10.1161/01.atv.20.9.2094
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Torzewski, M., Rist, C., Mortensen, R. F., Zwaka, T. P., Bienek, M., Waltenberger, J., Koenig, W., Schmitz, G., Hombach, V., & Torzewski, J. (2000). C-Reactive Protein in the Arterial Intima: Role of C-Reactive Protein Receptor–Dependent Monocyte Recruitment in Atherogenesis. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/01.atv.20.9.2094

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.