Cited by 1,402Lipoproteins and Cardiovascular HealthInflammatory Biomarkers in Disease PrognosisAcute Myocardial Infarction Research

High-Sensitivity C-Reactive Protein: Potential Adjunct for Global Risk Assessment in the Primary Prevention of Cardiovascular Disease

Ridker, Paul M.·2001·Circulation

Abstract

Abstract —Inflammation plays a major role in atherothrombosis, and measurement of inflammatory markers such as high-sensitivity C-reactive protein (HSCRP) may provide a novel method for detecting individuals at high risk of plaque rupture. Several large-scale prospective studies demonstrate that HSCRP is a strong independent predictor of future myocardial infarction and stroke among apparently healthy men and women and that the addition of HSCRP to standard lipid screening may improve global risk prediction among those with high as well as low cholesterol levels. Because agents such as aspirin and statins seem to attenuate inflammatory risk, HSCRP may also have utility in targeting proven therapies for primary prevention. Inexpensive commercial assays for HSCRP are now available; they have shown variability and classification accuracy similar to that of cholesterol screening. Risk prediction algorithms using a simple quintile approach to HSCRP evaluation have been developed for outpatient use. Thus, although limitations inherent to inflammatory screening remain, available data suggest that HSCRP has the potential to play an important role as an adjunct for global risk assessment in the primary prevention of cardiovascular disease.

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Crossref · 10.1161/01.cir.103.13.1813

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Authors
Ridker, P. M.
Affiliations
Brigham and Women's Hospital (US)
Corresponding author
Ridker, Paul M.
Venue
Circulation
Published
2001-04-03
Volume
103
Issue
13
Pages
1813-1818
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
OpenAlex
W2098657147
Cited by
1,402
References
56
Citations by year
2026: 27 · 2025: 18 · 2024: 23 · 2023: 14 · 2022: 22 · 2021: 30 · 2020: 27 · 2019: 26 · 2018: 39 · 2017: 39 · 2016: 50 · 2015: 50 · 2014: 58 · 2013: 43 · 2012: 54
FWCI
112.15
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Heart Association
  • National Heart, Lung, and Blood Institute (R01HL058755, HL 63293, HL-58755, R01HL063293)
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
Keywords
high-sensitivity C-reactive protein, inflammation, atherothrombosis, plaque rupture, cardiovascular risk prediction, myocardial infarction, stroke, primary prevention, aspirin, statins, inflammatory markers, lipid screening, risk assessment algorithm
MeSH terms
Algorithms, C-Reactive Protein, Cardiovascular Diseases, Cholesterol, Circadian Rhythm, Clinical Trials as Topic, Europe, Evaluation Studies as Topic, Female, Homocysteine, Humans, Inflammation, Male, Middle Aged, Myocardial Infarction, Obesity, Predictive Value of Tests, Prospective Studies, Sensitivity and Specificity, Smoking, United States, Cohort Studies, Lipoprotein(a), Risk Assessment, Hormone Replacement Therapy, Stroke

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