High-Sensitivity C-Reactive Protein: Potential Adjunct for Global Risk Assessment in the Primary Prevention of Cardiovascular Disease
Abstract
Abstract —Inflammation plays a major role in atherothrombosis, and measurement of inflammatory markers such as high-sensitivity C-reactive protein (HSCRP) may provide a novel method for detecting individuals at high risk of plaque rupture. Several large-scale prospective studies demonstrate that HSCRP is a strong independent predictor of future myocardial infarction and stroke among apparently healthy men and women and that the addition of HSCRP to standard lipid screening may improve global risk prediction among those with high as well as low cholesterol levels. Because agents such as aspirin and statins seem to attenuate inflammatory risk, HSCRP may also have utility in targeting proven therapies for primary prevention. Inexpensive commercial assays for HSCRP are now available; they have shown variability and classification accuracy similar to that of cholesterol screening. Risk prediction algorithms using a simple quintile approach to HSCRP evaluation have been developed for outpatient use. Thus, although limitations inherent to inflammatory screening remain, available data suggest that HSCRP has the potential to play an important role as an adjunct for global risk assessment in the primary prevention of cardiovascular disease.
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“71 mg/L) was similar to the lowest cut-off point used in the risk assessment algorithm in the primary prevention of Cardiovascular disease [6,32].”
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- Authors
- Ridker, P. M.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Ridker, Paul M.
- ORCID
- Ridker, Paul M.
- Venue
- Circulation
- Published
- 2001-04-03
- Volume
- 103
- Issue
- 13
- Pages
- 1813-1818
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2098657147
- Cited by
- 1,402
- References
- 56
- Citations by year
- 2026: 27 · 2025: 18 · 2024: 23 · 2023: 14 · 2022: 22 · 2021: 30 · 2020: 27 · 2019: 26 · 2018: 39 · 2017: 39 · 2016: 50 · 2015: 50 · 2014: 58 · 2013: 43 · 2012: 54
- FWCI
- 112.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- National Heart, Lung, and Blood Institute (R01HL058755, HL 63293, HL-58755, R01HL063293)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Keywords
- high-sensitivity C-reactive protein, inflammation, atherothrombosis, plaque rupture, cardiovascular risk prediction, myocardial infarction, stroke, primary prevention, aspirin, statins, inflammatory markers, lipid screening, risk assessment algorithm
- MeSH terms
- Algorithms, C-Reactive Protein, Cardiovascular Diseases, Cholesterol, Circadian Rhythm, Clinical Trials as Topic, Europe, Evaluation Studies as Topic, Female, Homocysteine, Humans, Inflammation, Male, Middle Aged, Myocardial Infarction, Obesity, Predictive Value of Tests, Prospective Studies, Sensitivity and Specificity, Smoking, United States, Cohort Studies, Lipoprotein(a), Risk Assessment, Hormone Replacement Therapy, Stroke
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