Reduced atherogenesis in cholesterol-fed diabetic rabbits. Giant lipoproteins do not enter the arterial wall
Open accessAbstract
In cholesterol-fed rabbits, alloxan-diabetes has an anti-atherogenic effect, which is associated with severe elevation of plasma triglyceride concentrations. To study this effect, we measured lipoprotein sizes and aortic permeability coefficients for cholesteryl ester and for albumin in hypertriglyceridemic diabetic cholesterol-fed rabbits and in normotriglyceridemic cholesterol-fed rabbits. With the same high cholesterol concentration in plasma, hypertriglyceridemic diabetic rabbits had 70% of plasma cholesterol in very large lipoproteins (diameter greater than 75 nm), whereas normotriglyceridemic rabbits had only about 10% of plasma cholesterol in these giant lipoproteins. The aortic permeability coefficients for cholesteryl ester in hypertriglyceridemic diabetic cholesterol-fed rabbits was only 10% to 50% of that in normotriglyceridemic cholesterol-fed rabbits. Aortic permeability coefficients for albumin did not differ significantly between the hypertriglyceridemic and normotriglyceridemic rabbits. The results suggest that the large size of a major fraction of plasma lipoproteins in the hypertriglyceridemic diabetic cholesterol-fed rabbits is responsible for the relatively low aortic permeability coefficient for cholesteryl ester from plasma and hence for reduced atherogenesis in these animals.
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Large TRL particles such as nascent chylomicrons are unable to penetrate the vessel wall.
“Large TRL particles such as nascent chylomicrons are unable to penetrate the vessel wall.23”
From Clinical review on triglycerides (2020) · cites this paper as [23]
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- Authors
- Nordestgaard, B. G., Stender, S., & Kjeldsen, K.
- Affiliations
- University of Copenhagen (DK)
- Venue
- Arteriosclerosis: An Official Journal of the American Heart Association, Inc.
- Published
- 1988-07
- Volume
- 8
- Issue
- 4
- Pages
- 421-428
- ISSN
- 0276-5047 (ISSN-L)
- OpenAlex
- W2170140062
- Cited by
- 137
- References
- 27
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 6 · 2019: 8 · 2018: 9 · 2017: 4 · 2016: 7 · 2015: 3 · 2014: 6 · 2013: 4
- FWCI
- 4.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Arteriosclerosis An Official Journal of the American Heart Association Inc (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Hjerteforeningen
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- atherogenesis, alloxan-induced diabetes, hypertriglyceridemia, cholesterol esters, albumin, cholesterol-fed rabbits
- MeSH terms
- Animals, Aorta, Arteriosclerosis, Blood Proteins, Cholesterol, Cholesterol Esters, Cholesterol, Dietary, Diabetes Mellitus, Experimental, Lipoproteins, Male, Permeability, Rabbits, Triglycerides
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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