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Cited by 533

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Prospective Study of C-Reactive Protein, Homocysteine, and Plasma Lipid Levels as Predictors of Sudden Cardiac Death

Open access
Albert, Christine M., Ma, Jing, Rifai, Nader, Stampfer, Meir J., Ridker, Paul M.·2002·Circulation
DOI 10.1161/01.cir.0000017493.03108.1c
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Abstract

Background — Sudden cardiac death (SCD) is an important cause of mortality even among apparently healthy populations. However, our ability to identify those at risk for SCD in the general population is poor, and more specific markers are needed. Methods and Results — To compare and contrast the relative importance of C-reactive protein (CRP), homocysteine, and lipids as long-term predictors of SCD, we performed a prospective, nested, case-control analysis involving 97 cases of SCD among apparently healthy men enrolled in the Physician’s Health Study. Of these plasma markers measured, only baseline CRP levels were significantly associated with the risk of SCD over the ensuing 17 years of follow-up ( P for trend=0.001). The increase in risk associated with CRP levels was primarily seen among men in the highest quartile, who were at a 2.78-fold increased risk of SCD (95% CI 1.35 to 5.72) compared with men in the lowest quartile. These results were not significantly altered in analyses that (in addition to the matching variables of age and smoking status) controlled for lipid parameters, homocysteine, and multiple cardiac risk factors (relative risk for highest versus lowest quartile 2.65, 95% CI 0.79 to 8.83; P for trend=0.03). In contrast to the positive relationship observed for CRP, neither homocysteine nor lipid levels were significantly associated with risk of SCD. Conclusions — These prospective data suggest that CRP levels may be useful in identifying apparently healthy men who are at an increased long-term risk of SCD.

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Metadata

Authors
Albert, C. M., Ma, J., Rifai, N., Stampfer, M. J., & Ridker, P. M.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2002-06-04
Volume
105
Issue
22
Pages
2595-2599
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.0000017493.03108.1c
OpenAlex
W2161465441
Cited by
533
References
26
FWCI
22.00
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Prospective Study of C-Reactive Protein, Homocysteine, and Plasma Lipid Levels as Predictors of Sudden Cardiac Death. https://app.cochat.ai/papers/10.1161/01.cir.0000017493.03108.1c
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Albert, C. M., Ma, J., Rifai, N., Stampfer, M. J., & Ridker, P. M. (2002). Prospective Study of C-Reactive Protein, Homocysteine, and Plasma Lipid Levels as Predictors of Sudden Cardiac Death. Circulation. https://doi.org/10.1161/01.cir.0000017493.03108.1c

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.