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Obesity Accelerates the Progression of Coronary Atherosclerosis in Young Men
Abstract
Background — Obesity is a risk factor for adult coronary heart disease and is increasing in prevalence among youths as well as adults. Results regarding the association of obesity with atherosclerosis are conflicting, particularly when analyses account for other risk factors. Methods and Results — The Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study collected arteries, blood, and other tissue from ≈3000 persons aged 15 to 34 years dying of external causes and autopsied in forensic laboratories. We measured gross atherosclerotic lesions in the right coronary artery (RCA), American Heart Association (AHA) lesion grade in the left anterior descending coronary artery (LAD), serum lipid concentrations, serum thiocyanate (for smoking), intimal thickness of renal arteries (for hypertension), glycohemoglobin (for hyperglycemia), and adiposity by body mass index (BMI) and thickness of the panniculus adiposus. BMI in young men was associated with both fatty streaks and raised lesions in the RCA and with AHA grade and stenosis in the LAD. The effect of obesity (BMI>30 kg/m 2 ) on RCA raised lesions was greater in young men with a thick panniculus adiposus. Obesity was associated with non-HDL and HDL (inversely) cholesterol concentrations, smoking (inversely), hypertension, and glycohemoglobin concentration, and these variables accounted for ≈15% of the effect of obesity on coronary atherosclerosis in young men. BMI was not associated with coronary atherosclerosis in young women although there was trend among those with a thick panniculus adiposus. Conclusions — Obesity is associated with accelerated coronary atherosclerosis in adolescent and young adult men. These observations support the current emphasis on controlling obesity to prevent adult coronary heart disease.
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“Indeed, central obesity is undeniably a risk marker, and probably a risk factor for the development and progression of coronary artery disease (43, 105, 185–188, 229, 241, 328).”
From Cardiac remodeling in obesity (2008) · cites this paper as [229]
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Metadata
- Authors
- McGill, H. C., McMahan, C. A., Herderick, E. E., Zieske, A. W., Malcom, G. T., Tracy, R. E., & Strong, J. P.
- Affiliations
- Louisiana State University (US)
- Venue
- Circulation
- Published
- 2002-06-11
- Volume
- 105
- Issue
- 23
- Pages
- 2712-2718
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2160710853
- Cited by
- 684
- References
- 37
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 23 · 2023: 42 · 2022: 18 · 2021: 20 · 2020: 22 · 2019: 17 · 2018: 17 · 2017: 19 · 2016: 18 · 2015: 29 · 2014: 28 · 2013: 44 · 2012: 31
- FWCI
- 19.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Nebraska Medical Center
- Vanderbilt University
- Ohio State University
- Louisiana State University
- National Institutes of Health (5r10hl033758-06, 5r10hl045715-04, 5r10hl033750-05, 5r10hl033748-02, 5r10hl033740-08, 5r10hl045693-04, 5r10hl033752-06, 5r10hl033778-04, 5r10hl033772-06, 5r10hl033733-03, 5r10hl033765-03, 5r10hl033746-08, 5r10hl033770-06, 5r10hl033728-08, 5r10hl033749-08, 5r10hl033760-08, 5r10hl045718-04, 5r01hl039913-09)
- University of Illinois at Urbana-Champaign
- University of Texas Health Science Center at San Antonio
- National Heart, Lung, and Blood Institute (HL-33728, HL 45694, 45720, 33740, HL 33760, HL-33758, HL 45715, 45715, HL-45718, HL-33752, HL 33772, HL-33746, HL 33750, HL-33740, HL 33733, HL-45693, HL-33778, HL 45720, HL33770, HL 45719, 33746, HL 39913, HL-33749, HL-33748, HL33765)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- obesity, coronary artery disease, young men, body mass index, coronary artery lesions, fatty streaks, coronary artery stenosis, serum cholesterol, smoking, hypertension, hyperglycemia, coronary heart disease prevention, adolescent and young adult males
- MeSH terms
- Adipose Tissue, Adolescent, Adult, Coronary Artery Disease, Coronary Disease, Coronary Vessels, Female, Humans, Male, Obesity, Risk Factors, Sex Factors, Body Mass Index, Disease Progression
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