The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Decreased Atherosclerotic Lesion Formation in Human Serum Paraoxonase Transgenic Mice
Abstract
Background — Serum paraoxonase (PON1), an enzyme carried on HDL, inhibits LDL oxidation, and in human population studies, low PON1 activity is associated with atherosclerosis. In addition, PON1 knockout mice are more susceptible to lipoprotein oxidation and atherosclerosis. To evaluate whether PON1 protects against atherosclerosis and lipid oxidation in a dose-dependent manner, we generated and studied human PON1 transgenic mice. Methods and Results — Human PON1 transgenic mice were produced by using bacterial artificial chromosome genomic clones. The mice had 2- to 4-fold increased plasma PON1 levels, but plasma cholesterol levels were unchanged. Atherosclerotic lesions were significantly reduced in the transgenic mice when both dietary and apoE-null mouse models were used. HDL isolated from the transgenic mice also protected against LDL oxidation more effectively. Conclusions — Our results indicate that PON1 protects against atherosclerosis in a dose-dependent manner and suggest that it may be a potential target for developing therapeutic agents for the treatment of cardiovascular disease.
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Roles of vascular oxidative stress and nitric oxide in the pathogenesis of atherosclerosis
Förstermann, U., Xia, N., & Li, H. (2017) · Circulation Research · doi:10.1161/circresaha.116.309326 · Cited by 1,519
Antiinflammatory Properties of HDL
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Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies
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Metadata
- Authors
- Tward, A., Xia, Y.-R., Wang, X.-P., Shi, Y.-S., Park, C., Castellani, L. W., Lusis, A. J., & Shih, D. M.
- Venue
- Circulation
- Published
- 2002-07-23
- Volume
- 106
- Issue
- 4
- Pages
- 484-490
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2154168373
- Cited by
- 455
- References
- 27
- FWCI
- 13.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Tward, A., Xia, Y.-R., Wang, X.-P., Shi, Y.-S., Park, C., Castellani, L. W., Lusis, A. J., & Shih, D. M. (2002). Decreased Atherosclerotic Lesion Formation in Human Serum Paraoxonase Transgenic Mice. Circulation. https://doi.org/10.1161/01.cir.0000023623.87083.4f
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
