The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Influence of Lipid-Lowering Therapy on the Progression of Coronary Artery Calcification: A Prospective Evaluation
Abstract
Background— Coronary calcification measured by fast computed tomography techniques is a surrogate marker of coronary atherosclerotic plaque burden. In a cohort study, we prospectively investigated whether lipid-lowering therapy with a cholesterol synthesis enzyme inhibitor reduces the progression of coronary calcification. Methods and Results— In 66 patients with coronary calcifications in electron beam tomography (EBT), LDL cholesterol >130 mg/dL, and no lipid-lowering treatment, the EBT scan was repeated after a mean interval of 14 months and treatment with cerivastatin was initiated (0.3 mg/d). After 12 months of treatment, a third EBT scan was performed. Coronary calcifications were quantified using a volumetric score. Cerivastatin therapy lowered the mean LDL cholesterol level from 164±30 to 107±21 mg/dL. The median calcified volume was 155 mm 3 (range, 15 to 1849) at baseline, 201 mm 3 (19 to 2486) after 14 months without treatment, and 203 mm 3 (15 to 2569) after 12 months of cerivastatin treatment. The median annualized absolute increase in coronary calcium was 25 mm 3 during the untreated versus 11 mm 3 during the treatment period ( P =0.01). The median annual relative increase in coronary calcium was 25% during the untreated versus 8.8% during the treatment period ( P <0.0001). In 32 patients with an LDL cholesterol level <100 mg/dL under treatment, the median relative change was 27% during the untreated versus −3.4% during the treatment period ( P =0.0001). Conclusions— Treatment with the cholesterol synthesis enzyme inhibitor cerivastatin significantly reduces coronary calcium progression in patients with LDL cholesterol >130 mg/dL.
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Cited by
A Randomized Trial of Intensive Lipid-Lowering Therapy in Calcific Aortic Stenosis
Cowell, S. J., Newby, D. E., Prescott, R. J., Bloomfield, P., Reid, J., Northridge, D. B., & Boon, N. A. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043876 · Cited by 1,146
Impact of Statins on Serial Coronary Calcification During Atheroma Progression and Regression
Puri, R., Nicholls, S. J., Shao, M., Kataoka, Y., Uno, K., Kapadia, S. R., Tuzcu, E. M., & Nissen, S. E. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.01.036 · Cited by 571
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Impact of Coronary Artery Calcium Scanning on Coronary Risk Factors and Downstream Testing
Rozanski, A., Gransar, H., Shaw, L. J., Kim, J., Miranda-Peats, L., Wong, N. D., Rana, J. S., Orakzai, R., Hayes, S. W., Friedman, J. D., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.01.019 · Cited by 458
De Backer, G., Ambrosioni, E., Broch-Johnsen, K., Brotons, C., Cifkova, R., Dallongeville, J., Ebrahim, S., Faergeman, O., Graham, I., Mancia, G., et al. (2003) · European Journal of Cardiovascular Prevention and Rehabilitation · doi:10.1097/00149831-200312001-00001 · Cited by 274
Metadata
- Authors
- Achenbach, S., Ropers, D., Pohle, K., Leber, A., Thilo, C., Knez, A., Menendez, T., Maeffert, R., Kusus, M., Regenfus, M., Bickel, A., Haberl, R., Steinbeck, G., Moshage, W., & Daniel, W. G.
- Venue
- Circulation
- Published
- 2002-08-27
- Volume
- 106
- Issue
- 9
- Pages
- 1077-1082
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2136078431
- Cited by
- 339
- References
- 32
- FWCI
- 34.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- Achenbach, S., Ropers, D., Pohle, K., Leber, A., Thilo, C., Knez, A., Menendez, T., Maeffert, R., Kusus, M., Regenfus, M., Bickel, A., Haberl, R., Steinbeck, G., Moshage, W., & Daniel, W. G. (2002). Influence of Lipid-Lowering Therapy on the Progression of Coronary Artery Calcification: A Prospective Evaluation. Circulation. https://doi.org/10.1161/01.cir.0000027567.49283.ff
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
