The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Intracellular Action of Matrix Metalloproteinase-2 Accounts for Acute Myocardial Ischemia and Reperfusion Injury
Abstract
Background— Matrix metalloproteinases are best recognized for their ability to degrade the extracellular matrix in both physiological and pathological conditions. However, recent findings indicate that some of them are also involved in mediating acute processes such as platelet aggregation and vascular tone. The acute contractile defect of the heart after ischemia-reperfusion may involve the proteolytic degradation of the thin filament protein troponin I; however, the protease responsible for this remains obscure. Methods and Results— Here we report that matrix metalloproteinase-2 is colocalized with troponin I within the thin myofilaments of cardiomyocytes in ischemic-reperfused hearts and that troponin I is a novel intracellular target for proteolytic cleavage by matrix metalloproteinase-2. Inhibition of matrix metalloproteinase-2 activity prevented ischemia-reperfusion-induced troponin I degradation and improved the recovery of mechanical function of the heart. Conclusions— These data reveal for the first time a novel molecular mechanism by which matrix metalloproteinase-2 causes acute myocardial dysfunction after ischemia-reperfusion-injury and that matrix metalloproteinase-2 has a biological action within the cell.
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Matrix Metalloproteinase-2 Contributes to Ischemia-Reperfusion Injury in the Heart
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Structure and function of matrix metalloproteinases and TIMPs
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Metadata
- Authors
- Wang, W., Schulze, C. J., Suarez-Pinzon, W. L., Dyck, J. R. B., Sawicki, G., & Schulz, R.
- Venue
- Circulation
- Published
- 2002-09-17
- Volume
- 106
- Issue
- 12
- Pages
- 1543-1549
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2126910504
- Cited by
- 484
- References
- 32
- FWCI
- 9.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wang, W., Schulze, C. J., Suarez-Pinzon, W. L., Dyck, J. R. B., Sawicki, G., & Schulz, R. (2002). Intracellular Action of Matrix Metalloproteinase-2 Accounts for Acute Myocardial Ischemia and Reperfusion Injury. Circulation. https://doi.org/10.1161/01.cir.0000028818.33488.7b
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