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Cited by 687

The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.

Tetracyclines Inhibit Connective Tissue Breakdown by Multiple Non-Antimicrobial Mechanisms

Golub, L.M., Lee, H.-M., Ryan, M.E., Giannobile, W.V., Payne, J., Sorsa, T.·1998·Advances in Dental Research
DOI 10.1177/08959374980120010501
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Abstract

A seminal experiment involving a germ-free rat model of connective tissue breakdown (followed soon thereafter by a series of in vitro studies) identified an unexpected non-antimicrobial property of tetracyclines (TCs). This ability of TCs to inhibit matrix metalloproteinases (MMPs) such as collagenase was found to reflect multiple direct and indirect mechanisms of action, and to be therapeutically useful in a variety of dental (e.g., adult periodontitis) and medical (e.g., arthritis, osteoporosis, cancer) diseases. The site on the TC molecule responsible for its MMP-inhibitory activity was identified which led to the development of a series of chemically modified non-antimicrobial analogs, called CMTs, which also have therapeutic potential but do not appear to induce antibiotic side-effects. Longitudinal double-blind studies on humans with adult periodontitis have demonstrated that a sub-antimicrobial dose of doxycycline (previously reported to suppress collagenase activity in the periodontal pocket) is safe and effective and has recently been approved by the FDA as an adjunct to scaling and root planing.

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Metadata

Authors
Golub, L. M., Lee, H.-M., Ryan, M. E., Giannobile, W. V., Payne, J., & Sorsa, T.
Venue
Advances in Dental Research
Publisher
SAGE Publications
Published
1998-11
Volume
12
Issue
1
Pages
12-26
ISSN
  • 0895-9374 (ISSN-L)
  • 1544-0737
DOI
10.1177/08959374980120010501
OpenAlex
W2136348600
Cited by
687
References
69
FWCI
18.05
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Tetracyclines Inhibit Connective Tissue Breakdown by Multiple Non-Antimicrobial Mechanisms. https://app.cochat.ai/papers/10.1177/08959374980120010501
The paper
Golub, L. M., Lee, H.-M., Ryan, M. E., Giannobile, W. V., Payne, J., & Sorsa, T. (1998). Tetracyclines Inhibit Connective Tissue Breakdown by Multiple Non-Antimicrobial Mechanisms. Advances in Dental Research. https://doi.org/10.1177/08959374980120010501

Data sources

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.