The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Central Sleep Apnea in Left Ventricular Dysfunction: Prevalence and Implications for Arrhythmic Risk
Open accessAbstract
Background— The prevalence and characteristics of sleep-disordered breathing in patients with asymptomatic left ventricular (LV) dysfunction are unknown. Therefore, we evaluated the prevalence of sleep-disordered breathing in patients with LV dysfunction without overt heart failure and tested the hypothesis that sleep-disordered breathing is linked to greater hemodynamic and autonomic impairment. Methods and Results— We studied 47 patients with LV ejection fractions ≤40% without any history of heart failure. Central sleep apnea (CSA), as defined by an apnea-hypopnea index ≥15/h, was present in 26 patients (55%), 17 (36%) of whom had severe CSA (apnea-hypopnea index ≥30/h). Obstructive sleep apnea was evident in 5 patients (11%). The prevalence and severity of CSA were higher in patients with ischemic cardiomyopathy than in patients with nonischemic cardiomyopathy ( P <0.05). Exercise tolerance and echocardiographic indices of systolic and diastolic function were similar in patients without CSA, with mild CSA, and with severe CSA. Heart rate variability was markedly depressed in patients with CSA ( P <0.05). Patients with severe CSA also had a higher incidence of nonsustained ventricular tachycardia ( P =0.05). Conclusions— CSA is highly prevalent in patients with asymptomatic LV dysfunction. The severity of CSA may not be related to the severity of hemodynamic impairment. Severe CSA is associated with impaired cardiac autonomic control and with increased cardiac arrhythmias.
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Cites
Heart rate variability: Standards of measurement, physiological interpretation, and clinical use
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A Mechanism of Central Sleep Apnea in Patients with Heart Failure
Javaheri, S. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909233411304 · Cited by 498
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Cited by
Goldberger, J. J., Cain, M. E., Hohnloser, S. H., Kadish, A. H., Knight, B. P., Lauer, M. S., Maron, B. J., Page, R. L., Passman, R. S., Siscovick, D., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.189375 · Cited by 1,450
Javaheri, S., Barbe, F., Campos-Rodriguez, F., Dempsey, J. A., Khayat, R., Javaheri, S., Malhotra, A., Martinez-Garcia, M. A., Mehra, R., Pack, A. I., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.11.069 · Cited by 1,434
Self-citationOldenburg, O., Lamp, B., Faber, L., Teschler, H., Horstkotte, D., & Töpfer, V. (2007) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2006.08.003 · Cited by 756
Sympathetic Nervous System Overactivity and Its Role in the Development of Cardiovascular Disease
Malpas, S. C. (2010) · Physiological Reviews · doi:10.1152/physrev.00007.2009 · Cited by 699
van Deursen, V. M., Urso, R., Laroche, C., Damman, K., Dahlström, U., Tavazzi, L., Maggioni, A. P., & Voors, A. A. (2014) · European Journal of Heart Failure · doi:10.1002/ejhf.30 · Cited by 468
Metadata
- Authors
- Lanfranchi, P. A., Somers, V. K., Braghiroli, A., Corra, U., Eleuteri, E., & Giannuzzi, P.
- Venue
- Circulation
- Published
- 2003-02-11
- Volume
- 107
- Issue
- 5
- Pages
- 727-732
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2096327296
- Cited by
- 298
- References
- 6
- FWCI
- 9.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lanfranchi, P. A., Somers, V. K., Braghiroli, A., Corra, U., Eleuteri, E., & Giannuzzi, P. (2003). Central Sleep Apnea in Left Ventricular Dysfunction: Prevalence and Implications for Arrhythmic Risk. Circulation. https://doi.org/10.1161/01.cir.0000049641.11675.ee
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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