The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Noninvasive Assessment of Left Ventricular Force-Frequency Relationships Using Tissue Doppler–Derived Isovolumic Acceleration: Validation in an Animal Model
Abstract
Background— We have demonstrated that myocardial acceleration during isovolumic contraction (IVA) is a sensitive index of right ventricular contractile function. In this study, we assessed the usefulness of IVA to measure left ventricular (LV) contractile function and force-frequency relationships in an experimental preparation. Methods and Results— In study 1, we examined 6 pigs by use of tissue Doppler imaging of LV free wall and simultaneous measurements of intraventricular pressure, volume, maximal elastance (E max ), and dP/dt max by conductance catheterization. Animals were paced via the right atrium at a rate of 130 bpm. IVA was compared with elastance during contractility modulation by esmolol and dobutamine and assessed during preload reduction and afterload increase. In study 2, in 6 more pigs, force-frequency data were obtained during incremental atrial pacing from 120 to 180 bpm. Study 1: Esmolol led to a decrease in IVA and E max ( P <0.03 and <0.02, respectively), both of which increased during dobutamine infusion ( P <0.02 and <0.03, respectively). IVA was unaffected by significant ( P <0.001) acute reduction of LV volume and a significantly increased LV afterload (systolic pressure increase, P <0.001). Study 2: There was a positive correlation between IVA and dP/dt max ( r 2 =0.92, P <0.05). As heart rate was increased from 120 to 160 bpm, there were significant increases in both IVA and dP/dt max ( P <0.0004 and P =0.02, respectively). Over the same range of heart rates, there was no significant change in E max ( P =0.22). Conclusions— IVA is a measurement of LV contractile function that is unaffected by preload and afterload changes within a physiological range and can be used noninvasively to measure LV force-frequency relationships.
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“Increasing pacing frequencies in swine results in increases in various indices of contractility such as dP/dtmax and myocardial acceleration during isovolumic contraction (IVA) (Vogel, et al., 2003; Vogel, et al., 2002).”
From Small and large animal models in cardiac contraction research: advantages and disadvantages (2014) · cites this paper as Vogel, et al., 2003
In the citing paper
“swine also have a positive force-frequency relationship as assessed by in vivo studies.”
From Small and large animal models in cardiac contraction research: advantages and disadvantages (2014) · cites this paper as Vogel, et al., 2003
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Metadata
- Authors
- Vogel, M., Cheung, M. M. H., Li, J., Kristiansen, S. B., Schmidt, M. R., White, P. A., Sorensen, K., & Redington, A. N.
- Affiliations
- Royal Papworth Hospital (GB)
- National Health Service (GB)
- From the Cardiothoracic Unit, Great Ormond Street Hospital for Children, NHS Trust, London, UK (M.V.); Division of Cardiology, Hospital for Sick Children, Toronto, Canada (M.M.H.C., J.L., A.N.R.); Department of Experimental Research and Cardiology, Skejby Hospital, Aarhus, Denmark (S.B.K., M.R.S., K.S.); and Papworth Hospital, Cambridge, UK (P.A.W.).
- ORCID
- Venue
- Circulation
- Published
- 2003-04
- Volume
- 107
- Issue
- 12
- Pages
- 1647-1652
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2076658601
- Cited by
- 213
- References
- 20
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 6 · 2016: 5 · 2015: 8 · 2014: 17 · 2013: 8 · 2012: 11
- FWCI
- 9.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Keywords
- isovolumic acceleration, left ventricular contractility, force-frequency relationship, tissue Doppler imaging, dP/dtmax, esmolol, dobutamine, heart rate, preload, afterload, non-invasive assessment
- MeSH terms
- Animals, Cardiac Pacing, Artificial, Heart Ventricles, Myocardial Contraction, Swine, Echocardiography, Doppler, Observer Variation, Ventricular Function, Ventricular Function, Left, Ventricular Pressure
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