Validation of Myocardial Acceleration During Isovolumic Contraction as a Novel Noninvasive Index of Right Ventricular Contractility: Comparison With Ventricular Pressure-Volume Relations in an Animal Model
Abstract
Background— We have demonstrated that myocardial acceleration during isovolumic contraction (IVA) is a sensitive index of left ventricular contractile function. In this study, we assessed the utility of IVA to measure right ventricular (RV) contractile function. Methods and Results— We examined 8 pigs by using tissue Doppler imaging of the RV free wall and simultaneous measurements of intraventricular pressure, volume, maximal elastance (e max ), preload recruitable stroke work, and dP/dt max by conductance catheterization. Animals were paced in the right atrium at a rate of 130 beats per minute (bpm). IVA was compared with elastance during contractility modulation by esmolol and dobutamine and during preload reduction and afterload increase by transient balloon occlusion of the inferior vena cava and pulmonary artery, respectively. Data were also obtained during incremental atrial pacing from 110 to 210 bpm. Esmolol led to a decrease in IVA and dP/dt max . During dobutamine infusion, IVA, dP/dt max , preload recruitable stroke work, and e max all increased significantly. During preload reduction and afterload increase, IVA remained constant up to a reduction of RV volume by 54% and an RV systolic pressure increase of 58%. Pacing up to a rate of 190 bpm led to a stepwise increase in IVA and dP/dt max , with a subsequent fall at a pacing rate of 210 bpm. Conclusions— IVA is a measurement of RV contractile function that is unaffected by preload and afterload changes in a physiological range and is able to measure the force-frequency relation. This novel index may be ideally suited to the assessment of acute changes of RV function in clinical studies.
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Swine also have a positive force-frequency relationship as assessed by in vivo studies.
“swine also have a positive force-frequency relationship as assessed by in vivo studies.”
From Small and large animal models in cardiac contraction research: advantages and disadvantages (2014) · cites this paper as Vogel, et al., 2002
Increasing pacing frequencies in swine increases indices of contractility such as dP/dtmax and myocardial acceleration during isovolumic contraction.
“Increasing pacing frequencies in swine results in increases in various indices of contractility such as dP/dtmax and myocardial acceleration during isovolumic contraction (IVA) (Vogel, et al., 2003; Vogel, et al., 2002).”
From Small and large animal models in cardiac contraction research: advantages and disadvantages (2014) · cites this paper as Vogel, et al., 2002
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Small and large animal models in cardiac contraction research: advantages and disadvantages
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- Authors
- Vogel, M., Schmidt, M. R., Kristiansen, S. B., Cheung, M., White, P. A., Sorensen, K., & Redington, A. N.
- Affiliations
- Great Ormond Street Hospital (GB)
- From the Cardiothoracic Unit (M.V., M.C., P.A.W., A.N.R.), Great Ormond Street Hospital for Children, NHS Trust, London, UK, and the Departments of Experimental Research (M.R.S., S.B.K.) and Cardiology (K.S.), Skejby Hospital, Aarhus, Denmark.
- ORCID
- Venue
- Circulation
- Published
- 2002-04-09
- Volume
- 105
- Issue
- 14
- Pages
- 1693-1699
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2011943289
- Cited by
- 443
- References
- 31
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 5 · 2023: 2 · 2022: 3 · 2021: 8 · 2020: 5 · 2019: 4 · 2018: 13 · 2017: 18 · 2016: 16 · 2015: 28 · 2014: 52 · 2013: 31 · 2012: 25
- FWCI
- 13.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Keywords
- isovolumic contraction, right ventricular contractility, right ventricular function, tissue Doppler imaging, preload recruitable stroke work, dP/dtmax, force-frequency relationship, esmolol, dobutamine, preload reduction, noninvasive cardiac function assessment
- MeSH terms
- Adrenergic beta-Agonists, Adrenergic beta-Antagonists, Animals, Blood Pressure, Cardiac Pacing, Artificial, Cardiac Volume, Cardiotonic Agents, Echocardiography, Electrocardiography, Cardiac Catheterization, Heart Rate, Heart Ventricles, Myocardial Contraction, Predictive Value of Tests, Swine, Observer Variation, Ventricular Function, Ventricular Function, Right, Electrophysiologic Techniques, Cardiac, Models, Animal
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