The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Short-Term Statin Therapy Improves Cardiac Function and Symptoms in Patients With Idiopathic Dilated Cardiomyopathy
Open accessAbstract
Background— Chronic heart failure is associated with inflammation and neurohormonal imbalance. The 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors, or statins, exert anti-inflammatory and vascular protective effects. We hypothesized that short-term statin therapy may have beneficial effects in patients with nonischemic heart failure. Methods and Results— Sixty-three patients with symptomatic, nonischemic, dilated cardiomyopathy were randomly divided into 2 groups. One group received simvastatin (n=24), and the other group received placebo (n=27). The initial dose of simvastatin was 5 mg/d, which was increased to 10 mg/d after 4 weeks. After 14 weeks, patients receiving simvastatin exhibited a modest reduction in serum cholesterol level compared with patients receiving placebo (130±13 versus 148±18, P <0.05). Patients treated with simvastatin had a lower New York Heart Association functional class compared with patients receiving placebo (2.04±0.06 versus 2.32±0.05, P <0.01). This corresponded to improved left ventricular ejection fraction in the simvastatin group (34±3 to 41±4%, P <0.05) but not in the placebo group. Furthermore, plasma concentrations of tumor necrosis factor-α, interleukin-6, and brain natriuretic peptide were significantly lower in the simvastatin group compared with the placebo group. Conclusions— Short-term statin therapy improves cardiac function, neurohormonal imbalance, and symptoms associated with idiopathic dilated cardiomyopathy. These findings suggest that statins may have therapeutic benefits in patients with heart failure irrespective of serum cholesterol levels or atherosclerotic heart disease.
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Cited by
PLEIOTROPIC EFFECTS OF STATINS
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Self-citationPleiotropic Effects of Statins on the Cardiovascular System
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Metadata
- Authors
- Node, K., Fujita, M., Kitakaze, M., Hori, M., & Liao, J. K.
- Venue
- Circulation
- Published
- 2003-08-19
- Volume
- 108
- Issue
- 7
- Pages
- 839-843
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1973523151
- Cited by
- 414
- References
- 32
- FWCI
- 26.61
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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