The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Vagal Nerve Stimulation Markedly Improves Long-Term Survival After Chronic Heart Failure in Rats
Open accessAbstract
Background— Diminished cardiac vagal activity and higher heart rate predict a high mortality rate of chronic heart failure (CHF) after myocardial infarction. We investigated the effects of chronic electrical stimulation of the vagus nerve on cardiac remodeling and long-term survival in an animal model of CHF after large myocardial infarction. Methods and Results— Two weeks after the ligation of the left coronary artery, surviving rats were randomized to vagal- and sham-stimulated groups. Using an implantable miniature radio-controlled electrical stimulator, we stimulated the right vagal nerve of CHF rats for 6 weeks. The intensity of electrical stimulation was adjusted for each rat, so that the heart rate was lowered by 20 to 30 beats per minute. The treated rats had significantly lower left ventricular end-diastolic pressure (17.1±5.9 versus 23.5±4.2 mm Hg, P <0.05) and higher maximum dp/dt of left ventricular pressure (4152±237 versus 2987±192 mm Hg/s, P <0.05) than the untreated rats. Improvement of cardiac pumping function was accompanied by a decrease in normalized biventricular weight (2.75±0.25 versus 3.14±0.22 g/kg, P <0.01). Although the 140-day survival of the untreated group was only half, vagal stimulation markedly improved the survival rate (86% versus 50%, P =0.008). Vagal stimulation therapy achieved a 73% reduction in a relative risk ratio of death. Conclusions— Vagal nerve stimulation markedly improved the long-term survival of CHF rats through the prevention of pumping failure and cardiac remodeling.
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The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
Pitt, B., Zannad, F., Remme, W. J., Cody, R., Castaigne, A., Perez, A., Palensky, J., & Wittes, J. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909023411001 · Cited by 9,214
(2000) · New England Journal of Medicine · doi:10.1056/nejm200001203420301 · Cited by 8,663
A Randomized Trial of the Angiotensin-Receptor Blocker Valsartan in Chronic Heart Failure
Cohn, J. N., & Tognoni, G. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010713 · Cited by 3,108
Effect of carvedilol on survival in severe chronic heart failure
Packer, M., Coats, A. J. S., Fowler, M. B., Katus, H. A., Krum, H., Mohacsi, P., Rouleau, J. L., Tendera, M., Castaigne, A., Roecker, E. B., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105313442201 · Cited by 3,093
Vanoli, E., De Ferrari, G. M., Stramba-Badiale, M., Hull, S. S., Foreman, R. D., & Schwartz, P. J. (1991) · Circulation Research · doi:10.1161/01.res.68.5.1471 · Cited by 681
Guarini, S., Altavilla, D., Cainazzo, M.-M., Giuliani, D., Bigiani, A., Marini, H., Squadrito, G., Minutoli, L., Bertolini, A., Marini, R., et al. (2003) · Circulation · doi:10.1161/01.cir.0000050627.90734.ed · Cited by 315
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Barter, P. J., Nicholls, S., Rye, K.-A., Anantharamaiah, G. M., Navab, M., & Fogelman, A. M. (2004) · Circulation Research · doi:10.1161/01.res.0000146094.59640.13 · Cited by 1,394
The cholinergic anti-inflammatory pathway
Pavlov, V. A., & Tracey, K. J. (2005) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2005.03.015 · Cited by 622
Chronic vagus nerve stimulation: A new and promising therapeutic approach for chronic heart failure
De Ferrari, G. M., Crijns, H. J. G. M., Borggrefe, M., Milasinovic, G., Smid, J., Zabel, M., Gavazzi, A., Sanzo, A., Dennert, R., Kuschyk, J., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehq391 · Cited by 523
Premchand, R. K., Sharma, K., Mittal, S., Monteiro, R., Dixit, S., Libbus, I., DiCarlo, L. A., Ardell, J. L., Rector, T. S., Amurthur, B., et al. (2014) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2014.08.009 · Cited by 377
Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics
Shivkumar, K., Ajijola, O. A., Anand, I., Armour, J. A., Chen, P., Esler, M., De Ferrari, G. M., Fishbein, M. C., Goldberger, J. J., Harper, R. M., et al. (2016) · The Journal of Physiology · doi:10.1113/jp271870 · Cited by 308
Metadata
- Authors
- Li, M., Zheng, C., Sato, T., Kawada, T., Sugimachi, M., & Sunagawa, K.
- Venue
- Circulation
- Published
- 2004-01-06
- Volume
- 109
- Issue
- 1
- Pages
- 120-124
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2068884498
- Cited by
- 612
- References
- 6
- FWCI
- 8.71
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Li, M., Zheng, C., Sato, T., Kawada, T., Sugimachi, M., & Sunagawa, K. (2004). Vagal Nerve Stimulation Markedly Improves Long-Term Survival After Chronic Heart Failure in Rats. Circulation. https://doi.org/10.1161/01.cir.0000105721.71640.da
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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