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Cited by 192Cardiac Imaging and DiagnosticsAdvanced MRI Techniques and ApplicationsCerebrovascular and Carotid Artery Diseases

Lipid-Rich Atherosclerotic Plaques Detected by Gadofluorine-Enhanced In Vivo Magnetic Resonance Imaging

Sirol, Marc, Itskovich, Vitalii V., Mani, Venkatesh, Aguinaldo, Juan Gilberto S., Fallon, John T., Misselwitz, Bernd, Weinmann, Hanns-Joachim, Fuster, Valentin +2 more·2004·Circulation
DOI 10.1161/01.cir.0000129310.17277.e7
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Abstract

Background— MRI of specific components in atherosclerotic plaque may provide information on plaque stability and its potential to rupture. We evaluated gadofluorine in atherosclerotic rabbits using a new MR sequence that allows plaque detection within 1 hour after injection and assessed enhancement in lipid-rich and non–lipid-rich plaques. Methods and Results— Twelve rabbits with aortic plaque and 6 controls underwent MRI before and up to 24 hours after gadofluorine injection (50 μmol/kg). Two T1-weighted, segmented gradient-echo sequences (TFL) were compared to enhance vessel wall delineation after injection: (1) an inversion-recovery prepulse (IR-TFL) or (2) a combination of inversion-recovery and diffusion-based flow suppression prepulses (IR-DIFF-TFL). With the use of IR-TFL at 1 hour after injection, the vessel wall was not delineated because of poor flow suppression; at 24 hours after injection, the enhancement was 37% ( P <0.01). IR-DIFF-TFL showed significant enhancement after versus before contrast (1 hour: 164% [ P <0.005]; 24 hours: 207% [ P <0.001]). At 1 hour and 24 hours after injection, the contrast-to-noise ratio was higher with the use of IR-DIFF-TFL than with IR-TFL (1 hour: 13.0±7.7 versus −19.8±10.3 [ P <0.001]; 24 hours: 15.2±5.9 versus 11.4±8.9, respectively [ P =0.052]). There was no enhancement in the vessel wall after gadofluorine injection in the control group. A strong correlation was found ( r 2 =0.87; P <0.001) between the lipid-rich areas in histological sections and signal intensity in corresponding MR images. This suggests a high affinity of gadofluorine for lipid-rich plaques. Conclusions— Gadofluorine-enhanced MRI improves atherosclerotic plaque detection. The IR-DIFF-TFL method allows early detection of atherosclerotic plaque within 1 hour after gadofluorine injection.

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Authors
Sirol, M., Itskovich, V. V., Mani, V., Aguinaldo, J. G. S., Fallon, J. T., Misselwitz, B., Weinmann, H.-J., Fuster, V., Toussaint, J.-F., & Fayad, Z. A.
Affiliations
  • Icahn School of Medicine at Mount Sinai (US)
  • From the Zena and Michael A. Wiener Cardiovascular Institute and Marie-Josée and Henry R. Kravis Cardiovascular Health Center (M.S., J.G.S.A., J.T.F., V.F., Z.A.F.), Imaging Science Laboratories, Department of Radiology (V.V.I., J.G.S.A., Z.A.F.), and Department of Pathology (J.T.F.), Mount Sinai School of Medicine, New York, NY; Schering AG, Berlin, Germany (B.M., H.W.); and Department of Physiology and Radioisotope, Hôpital Européen Georges Pompidou, Paris, France (J.-F.T.).
ORCID
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2004-06-15
Volume
109
Issue
23
Pages
2890-2896
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.0000129310.17277.e7
OpenAlex
W2149826221
Cited by
192
References
34
Citations by year
2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 2 · 2015: 4 · 2014: 7 · 2013: 5 · 2012: 14
FWCI
18.62
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Fédération Française de Cardiologie
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (R01HL071021)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cerebrovascular and Carotid Artery Diseases
Keywords
plaque detection, plaque enhancement, aortic plaque, contrast-to-noise ratio, plaque stability, rabbit model
MeSH terms
Animals, Aorta, Abdominal, Aortic Diseases, Arteriosclerosis, Catheterization, Contrast Media, Diet, Atherogenic, Fibrosis, Lipids, Magnetic Resonance Imaging, Organometallic Compounds, Rabbits

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