The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Relationship Between Erectile Dysfunction and Silent Myocardial Ischemia in Apparently Uncomplicated Type 2 Diabetic Patients
Open accessAbstract
Background— Erectile dysfunction (ED) is associated with coronary artery disease (CAD). In diabetic patients, CAD is often silent. Among diabetic patients with silent CAD, the prevalence of ED has never been evaluated. We investigated whether ED is associated with asymptomatic CAD in type 2 diabetic patients. Methods and Results— We evaluated the prevalence of ED in 133 uncomplicated diabetic men with angiographically verified silent CAD and in 127 diabetic men without myocardial ischemia at exercise ECG, 48-hour ambulatory ECG, and stress echocardiography. The groups were comparable for age and diabetes duration. Patients were screened for ED using the validated International Index of Erectile Function (IIEF-5) questionnaire. The prevalence of ED was significantly higher in patients with than in those without silent CAD (33.8% versus 4.7%; P =0.000). Multiple logistic regression analysis showed that ED, apolipoprotein(a) polymorphism, smoking, microalbuminuria, HDL, and LDL were significantly associated with silent CAD; among these risk factors, ED appeared to be the most efficient predictor of silent CAD (OR, 14.8; 95% CI, 3.8 to 56.9). Conclusions— Our study first shows a strong and independent association between ED and silent CAD in apparently uncomplicated type 2 diabetic patients. If our findings are confirmed, ED may become a potential marker to identify diabetic patients to screen for silent CAD. Moreover, the high prevalence of ED among diabetics with silent CAD suggests the need to perform an exercise ECG before starting a treatment for ED, especially in patients with additional cardiovascular risk factors.
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Cites
Impotence and Its Medical and Psychosocial Correlates: Results of the Massachusetts Male Aging Study
Feldman, H. A., Goldstein, I., Hatzichristou, D. G., Krane, R. J., & McKinlay, J. B. (1994) · Journal of Urology · doi:10.1016/s0022-5347(17)34871-1 · Cited by 5,074
Stamler, J., Vaccaro, O., Neaton, J. D., Wentworth, D., & The Multiple Risk Factor Intervention Trial Research Group (1993) · Diabetes Care · doi:10.2337/diacare.16.2.434 · Cited by 4,063
Park, K., Seo, J., Kang, H., Ryu, S., Kim, H., & Jeong, G. (2001) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3900649 · Cited by 162
Cited by
Tesfaye, S., Boulton, A. J. M., Dyck, P. J., Freeman, R., Horowitz, M., Kempler, P., Lauria, G., Malik, R. A., Spallone, V., Vinik, A., et al. (2010) · Diabetes Care · doi:10.2337/dc10-1303 · Cited by 2,690
Diabetic neuropathy: A position statement by the American Diabetes Association
Pop-Busui, R., Boulton, A. J. M., Feldman, E. L., Bril, V., Freeman, R., Malik, R. A., Sosenko, J. M., & Ziegler, D. (2017) · Diabetes Care · doi:10.2337/dc16-2042 · Cited by 2,602
Gupta, B. P. (2011) · Archives of Internal Medicine · doi:10.1001/archinternmed.2011.440 · Cited by 312
Corona, G., Mannucci, E., Forti, G., & Maggi, M. (2009) · International Journal of Andrology · doi:10.1111/j.1365-2605.2008.00951.x · Cited by 223
Araujo, A. B., Hall, S. A., Ganz, P., Chiu, G. R., Rosen, R. C., Kupelian, V., Travison, T. G., & McKinlay, J. B. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.08.058 · Cited by 153
Male Sexuality and Cardiovascular Risk. A Cohort Study in Patients with Erectile Dysfunction
Corona, G., Monami, M., Boddi, V., Cameron-Smith, M., Lotti, F., De Vita, G., Melani, C., Balzi, D., Sforza, A., Forti, G., et al. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01744.x · Cited by 134
Corona, G., Mannucci, E., Forti, G., & Maggi, M. (2009) · International Journal of Andrology · doi:10.1111/j.1365-2605.2009.00965.x · Cited by 96
Erectile dysfunction: a marker of silent coronary artery disease
Jackson, G. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl110 · Cited by 62
De Feyter, H. M., Praet, S. F., van den Broek, N. M., Kuipers, H., Stehouwer, C. D., Nicolay, K., Prompers, J. J., & van Loon, L. J. C. (2007) · Diabetes Care · doi:10.2337/dc07-0183 · Cited by 51
Metadata
- Authors
- Gazzaruso, C., Giordanetti, S., De Amici, E., Bertone, G., Falcone, C., Geroldi, D., Fratino, P., Solerte, S. B., & Garzaniti, A.
- Venue
- Circulation
- Published
- 2004-07-06
- Volume
- 110
- Issue
- 1
- Pages
- 22-26
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2123366678
- Cited by
- 327
- References
- 3
- FWCI
- 17.18
- Type
- journal article
- Language
- en
- Open access
- green
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