The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Oral D-4F Causes Formation of Pre-β High-Density Lipoprotein and Improves High-Density Lipoprotein–Mediated Cholesterol Efflux and Reverse Cholesterol Transport From Macrophages in Apolipoprotein E–Null Mice
Open accessAbstract
Background— These studies were designed to determine the mechanism of action of an oral apolipoprotein (apo) A-I mimetic peptide, D-4F, which previously was shown to dramatically reduce atherosclerosis in mice. Methods and Results— Twenty minutes after 500 μg of D-4F was given orally to apoE-null mice, small cholesterol-containing particles (CCPs) of 7 to 8 nm with pre-β mobility and enriched in apoA-I and paraoxonase activity were found in plasma. Before D-4F, both mature HDL and the fast protein liquid chromatography fractions containing the CCPs were proinflammatory. Twenty minutes after oral D-4F, HDL and CCPs became antiinflammatory, and there was an increase in HDL-mediated cholesterol efflux from macrophages in vitro. Oral D-4F also promoted reverse cholesterol transport from intraperitoneally injected cholesterol-loaded macrophages in vivo. In addition, oral D-4F significantly reduced lipoprotein lipid hydroperoxides (LOOH), except for pre-β HDL fractions, in which LOOH increased. Conclusions— The mechanism of action of oral D-4F in apoE-null mice involves rapid formation of CCPs, with pre-β mobility enriched in apoA-I and paraoxonase activity. As a result, lipoprotein LOOH are reduced, HDL becomes antiinflammatory, and HDL-mediated cholesterol efflux and reverse cholesterol transport from macrophages are stimulated.
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Citations
Cites
HDL and the Inflammatory Response Induced by LDL-Derived Oxidized Phospholipids
Navab, M., Berliner, J. A., Subbanagounder, G., Hama, S., Lusis, A. J., Castellani, L. W., Reddy, S., Shih, D., Shi, W., Watson, A. D., et al. (2001) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.21.4.481 · Cited by 442
Self-citationZhang, Y., Zanotti, I., Reilly, M. P., Glick, J. M., Rothblat, G. H., & Rader, D. J. (2003) · Circulation · doi:10.1161/01.cir.0000086981.09834.e0 · Cited by 436
Navab, M., Anantharamaiah, G. M., Hama, S., Garber, D. W., Chaddha, M., Hough, G., Lallone, R., & Fogelman, A. M. (2002) · Circulation · doi:10.1161/hc0302.103711 · Cited by 401
Self-citationShah, P. K., Yano, J., Reyes, O., Chyu, K.-Y., Kaul, S., Bisgaier, C. L., Drake, S., & Cercek, B. (2001) · Circulation · doi:10.1161/hc2501.092494 · Cited by 381
Navab, M., Hama, S. Y., Hough, G. P., Subbanagounder, G., Reddy, S. T., & Fogelman, A. M. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31582-0 · Cited by 334
Self-citationHigh-Density Lipoprotein Loses Its Anti-Inflammatory Properties During Acute Influenza A Infection
Van Lenten, B. J., Wagner, A. C., Nayak, D. P., Hama, S., Navab, M., & Fogelman, A. M. (2001) · Circulation · doi:10.1161/01.cir.103.18.2283 · Cited by 324
Self-citationCyrus, T., Praticò, D., Zhao, L., Witztum, J. L., Rader, D. J., Rokach, J., FitzGerald, G. A., & Funk, C. D. (2001) · Circulation · doi:10.1161/01.cir.103.18.2277 · Cited by 232
Datta, G., Chaddha, M., Hama, S., Navab, M., Fogelman, A. M., Garber, D. W., Mishra, V. K., Epand, R. M., Epand, R. F., Lund-Katz, S., et al. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31599-6 · Cited by 222
Self-citationFielding, C. J., & Fielding, P. E. (2001) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(01)00162-7 · Cited by 195
Remaley, A. T., Thomas, F., Stonik, J. A., Demosky, S. J., Bark, S. E., Neufeld, E. B., Bocharov, A. V., Vishnyakova, T. G., Patterson, A. P., Eggerman, T. L., et al. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m200475-jlr200 · Cited by 195
Cited by
Antiinflammatory Properties of HDL
Barter, P. J., Nicholls, S., Rye, K.-A., Anantharamaiah, G. M., Navab, M., & Fogelman, A. M. (2004) · Circulation Research · doi:10.1161/01.res.0000146094.59640.13 · Cited by 1,394
Self-citationHDL and cardiovascular disease: atherogenic and atheroprotective mechanisms
Navab, M., Reddy, S. T., Van Lenten, B. J., & Fogelman, A. M. (2011) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2010.222 · Cited by 656
Self-citationKontush, A., & Chapman, M. J. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.1 · Cited by 647
Molecular regulation of HDL metabolism and function: implications for novel therapies
Rader, D. J. (2006) · Journal of Clinical Investigation · doi:10.1172/jci30163 · Cited by 599
High-Density Lipoprotein as a Therapeutic Target: A Systematic Review
Singh, I. M., Shishehbor, M. H., & Ansell, B. J. (2007) · JAMA · doi:10.1001/jama.298.7.786 · Cited by 468
Metadata
- Authors
- Navab, M., Anantharamaiah, G. M., Reddy, S. T., Hama, S., Hough, G., Grijalva, V. R., Wagner, A. C., Frank, J. S., Datta, G., Garber, D., & Fogelman, A. M.
- Venue
- Circulation
- Published
- 2004-06-29
- Volume
- 109
- Issue
- 25
- Pages
- 3215-3220
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2122673417
- Cited by
- 323
- References
- 19
- FWCI
- 26.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Navab, M., Anantharamaiah, G. M., Reddy, S. T., Hama, S., Hough, G., Grijalva, V. R., Wagner, A. C., Frank, J. S., Datta, G., Garber, D., & Fogelman, A. M. (2004). Oral D-4F Causes Formation of Pre-β High-Density Lipoprotein and Improves High-Density Lipoprotein–Mediated Cholesterol Efflux and Reverse Cholesterol Transport From Macrophages in Apolipoprotein E–Null Mice. Circulation. https://doi.org/10.1161/01.cir.0000134275.90823.87
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