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Platelet Function Predicts Myocardial Damage in Patients With Acute Myocardial Infarction
Abstract
Background— Platelet activation is a hallmark of acute coronary syndromes. Numerous lines of evidence suggest a mechanistic link between von Willebrand factor or platelet hyperfunction and myocardial damage in patients with acute coronary syndromes. Thus, we assessed whether platelet function under high shear rates (collagen adenosine diphosphate closure times [CADP-CTs]) measured with the platelet function analyzer (PFA-100) may be enhanced in patients with myocardial infarction (MI) and whether it may predict the extent of myocardial damage as measured by creatine kinase (CK-MB) or troponin T (TnT) levels. Methods and Results— Patients with acute chest pain or symptoms suggestive of acute coronary syndromes (n=216) were prospectively examined at an emergency department. CADP-CT was significantly shorter in patients with MI, particularly in those with an ST-segment-elevation MI (STEMI) compared with the other patient groups (unstable angina, stable coronary artery disease, or controls). Furthermore, CADP-CT and collagen epinephrine–CT at presentation were independent predictors of myocardial damage as measured by CK-MB or TnT. Patients with MI whose CADP-CT values fell in the first quartile had 3-fold higher CK-MB and TnT levels than those in the fourth quartile. Conclusions— Patients with STEMI have significantly enhanced platelet function when measured under high shear rates. CADP-CT is an independent predictor of the severity of MI, as measured by markers of cardiac necrosis. Measurement of platelet function with the PFA-100 may help in the risk stratification of patients presenting with MI.
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“enhanced platelet reactivity is associated with both the extent of end organ injury and adverse prognosis (Frossard et al., 2004; Tantry et al., 2013).”
From Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk (2016) · cites this paper as Frossard et al., 2004
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Cites
Antman, E. M., Anbe, D. T., Armstrong, P. W., Bates, E., Green, L. A., Hand, M. M., Hochman, J. S., Krumholz, H. M., Kushner, F. G., Lamas, G. A., et al. (2004) · Circulation · doi:10.1161/01.cir.0000134791.68010.fa · Cited by 8,348
Antman, E. M., Bassand, J., Klein, W. W., Ohman, M. E., Sendón, J. L. L., Rydén, L., Simoons, M. L., & Tendera, M. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00804-4 · Cited by 4,824
Braunwald, E., Antman, E. M., Beasley, J. W., Califf, R. M., Cheitlin, M. D., Hochman, J. S., Jones, R. H., Kereiakes, D. J., Kupersmith, J., Levin, T. N., et al. (2000) · Circulation · doi:10.1161/01.cir.102.10.1193 · Cited by 4,475
Thompson, S. G., Kienast, J., Pyke, S., Haverkate, F., & van de Loo, J. C. W. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503093321003 · Cited by 1,819
Prognostic Value of Myeloperoxidase in Patients with Chest Pain
Brennan, M., Penn, M. S., Lente, F. V., Nambi, V., Shishehbor, M. H., Aviles, R. J., Goormastic, M., Pepoy, M. L., McErlean, E. S., Topol, E. J., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035003 · Cited by 1,071
D, E. B. M., Antman, E. M., Beasley, J. W., Califf, R. M., Cheitlin, M. D., Hochman, J. S., Jones, R. H., Kereiakes, D. J., Kupersmith, J., Levin, T. N., et al. (2002) · Circulation · doi:10.1161/01.cir.0000037106.76139.53 · Cited by 844
Ryan, T. J., Antman, E. M., Brooks, N. H., Califf, R. M., Hillis, L. D., Hiratzka, L. F., Rapaport, E., Riegel, B. J., Russell, R. O., Smith, E. E., et al. (1999) · Circulation · doi:10.1161/01.cir.100.9.1016 · Cited by 742
Enhanced Levels of Soluble and Membrane-Bound CD40 Ligand in Patients With Unstable Angina
Aukrust, P., Müller, F., Ueland, T., Berget, T., Aaser, E., Brunsvig, A., Solum, N. O., Forfang, K., Frøland, S. S., & Gullestad, L. L. (1999) · Circulation · doi:10.1161/01.cir.100.6.614 · Cited by 506
von Willebrand factor: a marker of endothelial dysfunction in vascular disorders?
Lip, G. Y. H. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00039-4 · Cited by 457
Roffi, M., Chew, D. P., Mukherjee, D., Bhatt, D. L., White, J. A., Heeschen, C., Hamm, C. W., Moliterno, D. J., Califf, R. M., White, H. D., et al. (2001) · Circulation · doi:10.1161/hc4801.100029 · Cited by 427
Increased Neutrophil-Platelet Adhesion in Patients With Unstable Angina
Ott, I., Neumann, F., Gawaz, M., Schmitt, M., & Scho¨mig, A. (1996) · Circulation · doi:10.1161/01.cir.94.6.1239 · Cited by 402
Barron, H. V., Cannon, C. P., Murphy, S. A., Braunwald, E., & Gibson, C. M. (2000) · Circulation · doi:10.1161/01.cir.102.19.2329 · Cited by 396
Increased Platelet Binding to Circulating Monocytes in Acute Coronary Syndromes
Sarma, J., Laan, C. A., Alam, S. R., Jha, A., Fox, K. A. A., & Dransfield, I. (2002) · Circulation · doi:10.1161/01.cir.0000015700.27754.6f · Cited by 362
von Willebrand factor in plasma: a novel risk factor for recurrent myocardial infarction and death.
Jansson, J., Nilsson, T., & Johnson, O. (1991) · Heart · doi:10.1136/hrt.66.5.351 · Cited by 356
Platelet Glycoprotein IIb/IIIa Receptor Inhibition in Non–ST-Elevation Acute Coronary Syndromes
Boersma, E. H., Akkerhuis, K. M., Théroux, P., Califf, R. M., Topol, E. J., & Simoons, M. L. (1999) · Circulation · doi:10.1161/01.cir.100.20.2045 · Cited by 302
Early and Late Effects of Clopidogrel in Patients With Acute Coronary Syndromes
Yusuf, S., Mehta, S. R., Zhao, F., Gersh, B. J., Commerford, P., Blumenthal, M., Budaj, A., Wittlinger, T., & Fox, K. A. A. (2003) · Circulation · doi:10.1161/01.cir.0000051362.96946.15 · Cited by 299
Platelet function analyzer (PFA-100): A tool to quantify congenital or acquired platelet dysfunction
Jilma, B. (2001) · Journal of Laboratory and Clinical Medicine · doi:10.1067/mlc.2001.117406 · Cited by 265
Self-citationIncreased Soluble Form of P-Selectin in Patients With Unstable Angina
Ikeda, H., Takajo, Y., Ichiki, K., Ueno, T., Maki, S., Noda, T., Sugi, K., & Imaizumi, T. (1995) · Circulation · doi:10.1161/01.cir.92.7.1693 · Cited by 199
Monitoring of Aspirin (ASA) Pharmacodynamics with the Platelet Function Analyzer PFA-100®
Homoncik, M., Hergovich, N., Stohlawetz, P. J., Panzer, S., Speiser, W., & Jilma, B. (2000) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1613805 · Cited by 197
Self-citationClinical application of the PFA-100®
Favaloro, E. J. (2002) · Current Opinion in Hematology · doi:10.1097/00062752-200209000-00004 · Cited by 178
Factor VIII/von Willebrand factor in subendothelium mediates platelet adhesion
Turitto, V. T., Weiss, H. J., Zimmerman, T., & Sussman, I. (1985) · Blood · doi:10.1182/blood.v65.4.823.bloodjournal654823 · Cited by 157
Reiter, R. A., Mayr, F., Blazicek, H., Galehr, E., Jilma‐Stohlawetz, P., Domanovits, H., & Jilma, B. (2003) · Blood · doi:10.1182/blood-2002-11-3566 · Cited by 143
Self-citationHarrison, P. J. (2000) · British Journal of Haematology · doi:10.1111/j.1365-2141.2000.02269.x · Cited by 135
Hantgan, R., Hindriks, G., Taylor, R., Sixma, J. J., & de Groot, P. G. (1990) · Blood · doi:10.1182/blood.v76.2.345.345 · Cited by 123
Prognostic Value of Myeloperoxidase in Patients With Chest Pain
Brennan, M., Penn, M. S., Lente, F. V., Nambi, V., Shishenbor, M. H., Aviles, R. J., Goormastic, M., Pepoy, M. L., McErlean, E. S., Topol, E. J., et al. (2004) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000119182.52833.5e · Cited by 118
Enhanced Shear-Induced Platelet Aggregation in Acute Myocardial Infarction
Goto, S., Sakai, H., Goto, M., Ono, M., Ikeda, Y., Handa, S., & Ruggeri, Z. M. (1999) · Circulation · doi:10.1161/01.cir.99.5.608 · Cited by 107
Thrombi in Acute Coronary Syndromes
Rentrop, K. P. (2000) · Circulation · doi:10.1161/01.cir.101.13.1619 · Cited by 99
Monitoring of antiplatelet therapy with the PFA-100® in peripheral angioplasty patients
Ziegler, S., Maca, T., Alt, E., Speiser, W., Schneider, B., & Minar, E. (2002) · Platelets · doi:10.1080/0953710021000057866 · Cited by 64
Impaired Platelet Function among Platelet Donors
Jilma‐Stohlawetz, P., Hergovich, N., Homoncik, M., Dzirlo, L., Horvath, M., Janisiw, M. P., Panzer, S., & Jilma, B. (2001) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1616146 · Cited by 63
Self-citationSystemic inflammation increases shear stress-induced platelet plug formation measured by the PFA-100
Homoncik, M., Blann, A. D., Hollenstein, U., Pernerstorfer, T., Eichler, H., & Jilma, B. (2000) · British Journal of Haematology · doi:10.1046/j.1365-2141.2000.02473.x · Cited by 62
Self-citationDerhaschnig, U., Laggner, A. N., Röggla, M., Hirschl, M. M., Kapiotis, S., Marsik, C. L., & Jilma, B. (2002) · Clinical Chemistry · doi:10.1093/clinchem/48.11.1924 · Cited by 37
Self-citationMadan, M., Berkowitz, S. D., Christie, D. J., Smit, A. C., Sigmon, K. N., & Tcheng, J. E. (2002) · American Heart Journal · doi:10.1067/mhj.2002.123581 · Cited by 31
Derhaschnig, U., Pachinger, C., & Jilma, B. (2004) · American Heart Journal · doi:10.1016/j.ahj.2003.11.003 · Cited by 29
Self-citationThe von Willebrand Factor in Myocardial Infarction and Unstable Angina: A Kinetic Study
Margulis, T., David, M., Maor, N., Soff, G. A., Grenadier, E., Palant, A., & Aghai, E. (1986) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1661565 · Cited by 29
Tamura, A., Watanabe, T., & Nasu, M. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)01815-x · Cited by 27
Targeting the use of platelet IIb/IIIa inhibitors: treatment of acute myocardial infarction.
Lincoff, A. M. (2002) · PubMed · Cited by 2
Research works printed but not linked: 12
- 10.1161/circ.100.6.614 · DOI
- 10.1161/circ.94.6.1239 · DOI
- 10.1161/circ.100.20.2045 · DOI
- 10.1161/circ.104.23.2767 · DOI
- 10.1182/blood.V65.4.823.823 · DOI
- 10.1161/circ.99.5.608 · DOI
- 10.1161/circ.100.9.1016 · DOI
- 2000, Br J Haematol, 111, 733
- 10.1161/circ.102.19.2329 · DOI
- 10.1161/circ.101.13.1619 · DOI
- 2003, J Thromb Haemost, 1, OC328.
- 2002, Rev Cardiovasc Med, 3, S13
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Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk
Zhu, W., Gregory, J. C., Org, E., Buffa, J. A., Gupta, N., Wang, Z., Li, L., Fu, X., Wu, Y., Mehrabian, M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.02.011 · Cited by 1,968
Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol
Erlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P., Mattila, P., & Jula, A. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.2.323 · Cited by 445
Hayward, C. P. M., Harrison, P., Cattaneo, M., Ortel, T. L., & Rao, A. K. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.01771.x · Cited by 405
Von Willebrand Factor in Cardiovascular Disease
Spiel, A. O., Gilbert, J. C., & Jilma, B. (2008) · Circulation · doi:10.1161/circulationaha.107.722827 · Cited by 403
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Metadata
- Authors
- Frossard, M., Fuchs, I., Leitner, J. M., Hsieh, K., Vlcek, M., Losert, H., Domanovits, H., Schreiber, W., Laggner, A. N., & Jilma, B.
- Affiliations
- University of Vienna (AT)
- Venue
- Circulation
- Published
- 2004-09-14
- Volume
- 110
- Issue
- 11
- Pages
- 1392-1397
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2156637699
- Cited by
- 254
- References
- 36
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 10 · 2023: 6 · 2022: 5 · 2021: 9 · 2020: 10 · 2019: 7 · 2018: 3 · 2017: 6 · 2016: 8 · 2015: 7 · 2014: 6 · 2013: 10 · 2012: 19
- FWCI
- 13.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Antiplatelet Therapy and Cardiovascular Diseases
- Keywords
- platelet function, acute myocardial infarction, ST-elevation myocardial infarction, platelet function analyzer, high shear rate, von Willebrand factor, platelet hyperreactivity, myocardial injury, creatine kinase-MB, troponin T, risk stratification, acute coronary syndrome
- MeSH terms
- Clopidogrel, Abciximab, Tirofiban, Eptifibatide, Adenosine Diphosphate, Aged, Antibodies, Monoclonal, Anticoagulants, Aspirin, Cardiovascular Agents, Collagen, Female, Humans, Immunoglobulin Fab Fragments, Leukocyte Count, Male, Middle Aged, Myocardial Infarction, Myocardium, Necrosis, Peptides, Platelet Aggregation Inhibitors, Platelet Function Tests, Predictive Value of Tests, Prospective Studies, Ticlopidine, Tyrosine, von Willebrand Factor, Platelet Activation, Comorbidity, Myocardial Ischemia
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