Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol
Open accessAbstract
Background Berries are a particularly rich source of polyphenols. They also contain other bioactive substances, such as vitamin C. Previous studies indicated that the consumption of polyphenol-rich foods (eg, cocoa, tea, and red wine) may induce beneficial changes in pathways related to cardiovascular health. Whether the consumption of berries has similar effects is unknown.Objective We aimed to investigate the effects of berry consumption on hemostatic function, serum lipids, and blood pressure (BP).Design Middle-aged unmedicated subjects (n = 72) with cardiovascular risk factors consumed moderate amounts of berry or control products for 8 wk in a single-blind, randomized, placebo-controlled intervention trial.Results Berry consumption inhibited platelet function as measured with a platelet function analyzer (using collagen and ADP as platelet activator) [changes: 11% and -1.4% in the berry and control groups, respectively; P = 0.018, analysis of covariance (ANCOVA)]. Plasma biomarkers of platelet activation, coagulation, and fibrinolysis did not change during the intervention. Serum HDL-cholesterol concentrations increased significantly more (P = 0.006, ANCOVA) in the berry than in the control group (5.2% and 0.6%, respectively), but total cholesterol and triacylglycerol remained unchanged. Systolic BP decreased significantly (P = 0.050, ANCOVA); the decrease mostly occurred in subjects with high baseline BP (7.3 mm Hg in highest tertile; P = 0.024, ANCOVA). Polyphenol and vitamin C concentrations in plasma increased, whereas other nutritional biomarkers (ie, folate, tocopherols, sodium, and potassium) were unaffected.Conclusion The consumption of moderate amounts of berries resulted in favorable changes in platelet function, HDL cholesterol, and BP. The results indicate that regular consumption of berries may play a role in the prevention of cardiovascular disease.
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Of 20 trials conducted using different varieties of fresh and processed berry products, only two showed a significant decrease in systolic blood pressure: one in healthy men following cranberry juice supplementation and the other in subjects with CVD risk factors following mixed berry supplementation.
“Of 20 trials conducted using different varieties of fresh and processed berry products, only two showed a significant decrease in systolic blood pressure: one was conducted in healthy men following cranberry juice supplementation46 and the other was in subjects with CVD risk factors following mixed berry supplementation.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [49]
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“…IH -PA Author M anuscript N IH -PA Author M anuscript Reference Duration Study design Study subjects Control Berry intervention Significant findings Erlund et al. (2008)49 8 weeks Randomized, single-blind, placebo-controlled, trial 72 subjects with cardiovascular risk factors (mean age: control…”
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- Authors
- Erlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P., Mattila, P., & Jula, A.
- Affiliations
- Finnish Red Cross (FI)
- Corresponding author
- Erlund, Iris
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2008-02
- Volume
- 87
- Issue
- 2
- Pages
- 323-331
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2125049342
- Cited by
- 445
- References
- 49
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 15 · 2023: 20 · 2022: 21 · 2021: 25 · 2020: 28 · 2019: 22 · 2018: 30 · 2017: 26 · 2016: 37 · 2015: 24 · 2014: 33 · 2013: 31 · 2012: 37
- FWCI
- 15.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Jukuri (Natural Resources Institute Finland (Luke)) (submittedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
- Keywords
- berry consumption, polyphenols, vitamin C, platelet function, platelet activation, HDL cholesterol, blood pressure, serum lipids, cardiovascular risk factors, cardiovascular disease prevention, dietary intervention, plasma biomarkers
- MeSH terms
- Adult, Aged, Blood Coagulation, Blood Platelets, Blood Pressure, Female, Flavonoids, Fruit, Humans, Cholesterol, HDL, Male, Middle Aged, Phenols, Biomarkers, Polyphenols
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