The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Prognostic Impact of Plasma N-Terminal Pro–Brain Natriuretic Peptide in Severe Chronic Congestive Heart Failure: A Substudy of the Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) Trial
Open accessAbstract
Background— The utility of N-terminal proBNP (NT-proBNP) to predict the occurrence of death and hospitalization was prospectively evaluated in the COPERNICUS study, which enrolled patients with an ejection fraction <25% and symptoms of chronic congestive heart failure at rest or on minimal exertion. Methods and Results— Baseline plasma concentrations of NT-proBNP were measured in a subgroup of 814 men and 197 women with symptoms at rest or on minimal exertion who were enrolled in the COPERNICUS study and were randomized to placebo (n=506) or carvedilol (n=505). Values of NT-proBNP were markedly increased despite the requirement that patients be euvolemic before the start of treatment (mean±SD, 3235±4392 pg/mL; median, 1767 pg/mL). By univariate Cox regression analysis, NT-proBNP was found to be a powerful predictor of subsequent all-cause mortality (relative risk [RR], 2.7; 95% CI, 1.7 to 4.3; P =0.0001 for above versus below median) and all-cause mortality or hospitalization for heart failure (RR, 2.4; 95% CI, 1.8 to 3.4; P =0.0001 for above versus below median). The predictive value of NT-proBNP was similar when both placebo and carvedilol patients were analyzed separately. No significant interaction was found between NT-proBNP and treatment group ( P =0.93 for above- versus below-median NT-proBNP). Conclusions— NT-proBNP was consistently associated with increased risk for all-cause mortality and for all-cause mortality or hospitalization for heart failure in patients with severe congestive heart failure, even in those who were clinically euvolemic. This marker therefore may be a useful tool in risk stratification of patients with severe congestive heart failure.
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Cites
Plasma Norepinephrine as a Guide to Prognosis in Patients with Chronic Congestive Heart Failure
Cohn, J. N., Levine, T. B., Olivari, M. T., Garberg, V., Lura, D., Francis, G. S., Simon, A. B., & Rector, T. (1984) · New England Journal of Medicine · doi:10.1056/nejm198409273111303 · Cited by 3,125
Effect of carvedilol on survival in severe chronic heart failure
Packer, M., Coats, A. J. S., Fowler, M. B., Katus, H. A., Krum, H., Mohacsi, P., Rouleau, J. L., Tendera, M., Castaigne, A., Roecker, E. B., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105313442201 · Cited by 3,093
Self-citationEffect of carvedilol on survival in severe chronic heart failure
Packer, M., Coats, A. J. S., & Fowler, M. B. (2001) · ACC Current Journal Review · doi:10.1016/s1062-1458(01)00477-9 · Cited by 1,661
Self-citationFrancis, G. S., Benedict, C., Johnstone, D. E., Kirlin, P. C., Nicklas, J., Liang, C. S., Kubo, S. H., Rudin-Toretsky, E., & Yusuf, S. (1990) · Circulation · doi:10.1161/01.cir.82.5.1724 · Cited by 1,388
Tsutamoto, T., Wada, A., Maeda, K., Hisanaga, T., Maeda, Y., Fukai, D., Ohnishi, M., Sugimoto, Y., & Kinoshita, M. (1997) · Circulation · doi:10.1161/01.cir.96.2.509 · Cited by 963
Omland, T., Aakvaag, A., Bonarjee, V. V. S., Caidahl, K., Lie, R. T., Nilsen, D. W. T., Sundsfjord, J. A., & Dickstein, K. (1996) · Circulation · doi:10.1161/01.cir.93.11.1963 · Cited by 700
Richards, A. M., Nicholls, M. G., Yandle, T. G., Frampton, C., Espiner, E. A., Turner, J. G., Buttimore, R. C., Lainchbury, J. G., Elliott, J. M., Ikram, H., et al. (1998) · Circulation · doi:10.1161/01.cir.97.19.1921 · Cited by 646
Cohn, J. N., Johnson, G. R., Shabetai, R. W., Loeb, H. S., Tristani, F. E., Rector, T. S., Smith, R., & Fletcher, R. D. (1993) · PubMed · Cited by 533
Plasma N-terminal pro-brain natriuretic peptide and adrenomedullin
Richards, A. M., Doughty, R., Nicholls, M. G., MacMahon, S., Sharpe, N., Murphy, J., Espiner, E. A., Frampton, C., & Yandle, T. G. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01269-4 · Cited by 389
Francis, G. S., Cohn, J. N., Johnson, G., Rector, T. S., Goldman, S., & Simon, A. (1993) · PubMed · Cited by 354
Cited by
Cleland, J. G. F., Louis, A. A., Rigby, A. S., Janssens, U., & Balk, A. H. M. M. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.01.050 · Cited by 700
Jaski, B. E., Jessup, M. L., Mancini, D. M., Cappola, T. P., Pauly, D. F., Greenberg, B., Borow, K., Dittrich, H., Zsebo, K. M., & Hajjar, R. J. (2009) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2009.01.013 · Cited by 457
Development of a Ventilatory Classification System in Patients With Heart Failure
Arena, R., Myers, J., Abella, J., Peberdy, M. A., Bensimhon, D., Chase, P., & Guazzi, M. (2007) · Circulation · doi:10.1161/circulationaha.107.686576 · Cited by 391
Bodaghi, A., Fattahi, N., & Ramazani, A. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e13323 · Cited by 336
Retracted
Metadata
- Authors
- Hartmann, F., Packer, M., Coats, A. J. S., Fowler, M. B., Krum, H., Mohacsi, P., Rouleau, J. L., Tendera, M., Castaigne, A., Anker, S. D., Amann-Zalan, I., Hoersch, S., & Katus, H. A.
- Venue
- Circulation
- Published
- 2004-09-28
- Volume
- 110
- Issue
- 13
- Pages
- 1780-1786
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2004779219
- Cited by
- 301
- References
- 18
- FWCI
- 11.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Prognostic Impact of Plasma N-Terminal Pro–Brain Natriuretic Peptide in Severe Chronic Congestive Heart Failure: A Substudy of the Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) Trial. https://app.cochat.ai/papers/10.1161/01.cir.0000143059.68996.a7
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- Hartmann, F., Packer, M., Coats, A. J. S., Fowler, M. B., Krum, H., Mohacsi, P., Rouleau, J. L., Tendera, M., Castaigne, A., Anker, S. D., Amann-Zalan, I., Hoersch, S., & Katus, H. A. (2004). Prognostic Impact of Plasma N-Terminal Pro–Brain Natriuretic Peptide in Severe Chronic Congestive Heart Failure: A Substudy of the Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) Trial. Circulation. https://doi.org/10.1161/01.cir.0000143059.68996.a7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
