The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Cardiomyocyte Stiffness in Diastolic Heart Failure
Open accessAbstract
BACKGROUND: Heart failure with preserved left ventricular (LV) ejection fraction (EF) is increasingly recognized and usually referred to as diastolic heart failure (DHF). Its pathogenetic mechanism remains unclear, partly because of a lack of myocardial biopsy material. Endomyocardial biopsy samples obtained from DHF patients were therefore analyzed for collagen volume fraction (CVF) and sarcomeric protein composition and compared with control samples. Single cardiomyocytes were isolated from these biopsy samples to assess cellular contractile performance. METHODS AND RESULTS: DHF patients (n=12) had an LVEF of 71+/-11%, an LV end-diastolic pressure (LVEDP) of 28+/-4 mm Hg, and no significant coronary artery stenoses. DHF patients had higher CVFs (7.5+/-4.0%, P<0.05) than did controls (n=8, 3.8+/-2.0%), and no conspicuous changes in sarcomeric protein composition were detected. Cardiomyocytes, mechanically isolated and treated with Triton X-100 to remove all membranes, were stretched to a sarcomere length of 2.2 microm and activated with solutions containing varying [Ca2+]. Compared with cardiomyocytes of controls, cardiomyocytes of DHF patients developed a similar total isometric force at maximal [Ca2+], but their resting tension (F(passive)) in the absence of Ca2+ was almost twice as high (6.6+/-3.0 versus 3.5+/-1.7 kN/m2, P<0.001). F(passive) and CVF combined yielded stronger correlations with LVEDP than did either alone. Administration of protein kinase A (PKA) to DHF cardiomyocytes lowered F(passive) to control values. CONCLUSIONS: DHF patients had stiffer cardiomyocytes, as evident from a higher F(passive) at the same sarcomere length. Together with CVF, F(passive) determined in vivo diastolic LV dysfunction. Correction of this high F(passive) by PKA suggests that reduced phosphorylation of sarcomeric proteins is involved in DHF.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Increased Fpassive has been observed in HFpEF patient biopsies, and increased cardiac stiffening is associated with aging.38,39”
From The cardioprotective effects of semaglutide exceed those of dietary weight loss in mice with HFpEF (2023) · cites this paper as [39]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Yusuf, S., Pfeffer, M. A., Swedberg, K., Granger, C. B., Held, P., McMurray, J. J., Michelson, E. L., Olofsson, B., & Östergren, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14285-7 · Cited by 2,994
Burden of Systolic and Diastolic Ventricular Dysfunction in the Community
Redfield, M. M., Jacobsen, S. J., Burnett, J. C. J., Mahoney, D. W., Bailey, K. R., & Rodeheffer, R. J. (2003) · JAMA · doi:10.1001/jama.289.2.194 · Cited by 2,989
Zile, M. R., Baicu, C. F., & Gaasch, W. H. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032566 · Cited by 1,577
New Concepts in Diastolic Dysfunction and Diastolic Heart Failure: Part I
Zile, M. R., & Brutsaert, D. L. (2002) · Circulation · doi:10.1161/hc1102.105289 · Cited by 1,185
Phospholamban: a crucial regulator of cardiac contractility
MacLennan, D. H., & Kranias, E. G. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1151 · Cited by 1,088
Kawaguchi, M., Hay, I., Fetics, B. J., & Kass, D. A. (2003) · Circulation · doi:10.1161/01.cir.0000048123.22359.a0 · Cited by 929
Kitzman, D. W. (2002) · JAMA · doi:10.1001/jama.288.17.2144 · Cited by 883
Lisinopril-Mediated Regression of Myocardial Fibrosis in Patients With Hypertensive Heart Disease
Brilla, C. G., FUNCK, R. C., & Rupp, H. (2000) · Circulation · doi:10.1161/01.cir.102.12.1388 · Cited by 653
How to diagnose diastolic heart failure
Paulus, W. J., Brutsaert, D. L., Gillebert, T. C., Rademakers, F., Stanislas, U., Leite-Moreira, A. F., Om, H., Zh, J., Kaufmann, P. A., Mandinov, L., et al. (1998) · Ghent University Academic Bibliography (Ghent University) · Cited by 649
How to diagnose diastolic heart failure
European Study Group on Diastolic H (1998) · European Heart Journal · doi:10.1053/euhj.1998.1057 · Cited by 616
Research works printed but not linked: 9
Cited by
Sorted by citations
A Novel Paradigm for Heart Failure With Preserved Ejection Fraction
Paulus, W. J., & Tschöpe, C. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.02.092 · Cited by 3,564
Self-citationPaulus, W. J., Tschöpe, C., Sanderson, J. E., Rusconi, C., Flachskampf, F. A., Rademakers, F. E., Marino, P. N., Smiseth, O. A., Keulenaer, G. W. D., Leite-Moreira, A. F., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm037 · Cited by 2,646
Cardioprotection and lifespan extension by the natural polyamine spermidine
Eisenberg, T., Abdellatif, M., Schroeder, S., Primessnig, U., Stekovic, S., Pendl, T., Harger, A., Schipke, J., Zimmermann, A., Schmidt, A., et al. (2016) · Nature Medicine · doi:10.1038/nm.4222 · Cited by 1,168
Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment
Borlaug, B. A., & Paulus, W. J. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq426 · Cited by 1,136
Physiological and pathological cardiac hypertrophy
Shimizu, I., & Minamino, T. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.06.001 · Cited by 919
Mohammed, S. F., Hussain, S., Mirzoyev, S. A., Edwards, W. D., Maleszewski, J. J., & Redfield, M. M. (2015) · Circulation · doi:10.1161/circulationaha.114.009625 · Cited by 874
Braunwald, E. (2013) · JACC Heart Failure · doi:10.1016/j.jchf.2012.10.002 · Cited by 862
The pathophysiology of heart failure with preserved ejection fraction
Borlaug, B. A. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.83 · Cited by 726
van Heerebeek, L., Hamdani, N., Handoko, M. L., Falcao-Pires, I., Musters, R. J., Kupreishvili, K., Ijsselmuiden, A. J. J., Schalkwijk, C. G., Bronzwaer, J. G. F., Diamant, M., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.728550 · Cited by 723
Zile, M. R., Baicu, C. F., S. Ikonomidis, J., Stroud, R. E., Nietert, P. J., Bradshaw, A. D., Slater, R., Palmer, B. M., Van Buren, P., Meyer, M., et al. (2015) · Circulation · doi:10.1161/circulationaha.114.013215 · Cited by 681
Myocardial Structure and Function Differ in Systolic and Diastolic Heart Failure
van Heerebeek, L., Borbély, A., Niessen, H. W. M., Bronzwaer, J. G. F., van der Velden, J., Stienen, G. J. M., Linke, W. A., Laarman, G. J., & Paulus, W. J. (2006) · Circulation · doi:10.1161/circulationaha.105.587519 · Cited by 655
Westermann, D., Lindner, D., Kasner, M., Zietsch, C., Savvatis, K., Escher, F., von Schlippenbach, J., Skurk, C., Steendijk, P., Riad, A., et al. (2011) · Circulation Heart Failure · doi:10.1161/circheartfailure.109.931451 · Cited by 644
Lam, C. S. P., Roger, V. L., Rodeheffer, R. J., Bursi, F., Borlaug, B. A., Ommen, S. R., Kass, D. A., & Redfield, M. M. (2007) · Circulation · doi:10.1161/circulationaha.106.659763 · Cited by 544
Low Myocardial Protein Kinase G Activity in Heart Failure With Preserved Ejection Fraction
van Heerebeek, L., Hamdani, N., Falcão‐Pires, I., Leite-Moreira, A. F., Begieneman, M. P. V., Bronzwaer, J. G. F., van der Velden, J., Stienen, G. J. M., Laarman, G. J., Somsen, G. A., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.076075 · Cited by 545
Heart Failure With Preserved Ejection Fraction: Mechanisms, Clinical Features, and Therapies
Sharma, K., & Kass, D. A. (2014) · Circulation Research · doi:10.1161/circresaha.115.302922 · Cited by 508
Diastolic and Systolic Heart Failure Are Distinct Phenotypes Within the Heart Failure Spectrum
Borlaug, B. A., & Redfield, M. M. (2011) · Circulation · doi:10.1161/circulationaha.110.954388 · Cited by 451
Cellular and molecular pathobiology of heart failure with preserved ejection fraction
Mishra, S., & Kass, D. A. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-020-00480-6 · Cited by 437
Krüger, M., Kötter, S., Grützner, A., Lang, P. M., Andresen, C., Redfield, M. M., Butt, E., dos Remedios, C. G., & Linke, W. A. (2008) · Circulation Research · doi:10.1161/circresaha.108.184408 · Cited by 408
From Systemic Inflammation to Myocardial Fibrosis
Paulus, W. J., & Zile, M. R. (2021) · Circulation Research · doi:10.1161/circresaha.121.318159 · Cited by 413
Simmonds, S. J., Cuijpers, I., Heymans, S. R. B., & Jones, E. A. V. (2020) · Cells · doi:10.3390/cells9010242 · Cited by 399
Right Ventricular Diastolic Impairment in Patients With Pulmonary Arterial Hypertension
Rain, S., Handoko, M. L., Trip, P., Gan, C. T., Westerhof, N., Stienen, G. J. M., Paulus, W. J., Ottenheijm, C. A. C., Marcus, J. T., Dorfmüller, P., et al. (2013) · Circulation · doi:10.1161/circulationaha.113.001873 · Cited by 372
Borbély, A., Falcão‐Pires, I., van Heerebeek, L., Hamdani, N., Edes, I. F., Gavina, C., Leite-Moreira, A. F., Bronzwaer, J. G. F., Papp, Z., van der Velden, J., et al. (2009) · Circulation Research · doi:10.1161/circresaha.108.193326 · Cited by 369
Senni, M., Paulus, W. J., Gavazzi, A., Fraser, A. G., Dı́ez, J., Solomon, S. D., Smiseth, O. A., Guazzi, M., Lam, C. S. P., Maggioni, A. P., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu204 · Cited by 352
Heart failure with preserved ejection fraction: from mechanisms to therapies
Lam, C. S. P., Voors, A. A., de Boer, R. A., Solomon, S. D., & van Veldhuisen, D. J. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy301 · Cited by 355
Unlocking the Mysteries of Diastolic Function
Lester, S. J., Tajik, A. J., Nishimura, R. A., Oh, J. K., Khandheria, B. K., & Seward, J. B. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.09.061 · Cited by 348
Kašner, M., Westermann, D., López, B., Gaub, R., Escher, F., Kühl, U., Schultheiß, H., & Tschöpe, C. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.10.024 · Cited by 330
Cardiac Myosin-Binding Protein C Mutations and Hypertrophic Cardiomyopathy
van Dijk, S. J., Dooijes, D., dos Remedios, C. G., Michels, M., Lamers, J. M. J., Winegrad, S., Schlossarek, S., Carrier, L., ten Cate, F. J., Stienen, G. J. M., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.838672 · Cited by 328
Ventricular–Vascular Interaction in Heart Failure
Borlaug, B. A., & Kass, D. A. (2008) · Heart Failure Clinics · doi:10.1016/j.hfc.2007.10.001 · Cited by 315
Hahn, V. S., Yanek, L. R., Vaishnav, J., Ying, W., Vaidya, D. M., Lee, Y. J., Riley, S. J., Subramanya, V., Brown, E. E., Hopkins, C. D., et al. (2020) · JACC Heart Failure · doi:10.1016/j.jchf.2020.04.007 · Cited by 325
Linke, W. A. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.03.029 · Cited by 305
Myocardial Gene Expression Signatures in Human Heart Failure With Preserved Ejection Fraction
Hahn, V. S., Knutsdottir, H., Luo, X., Bedi, K., Margulies, K. B., Haldar, S. M., Stolina, M., Yin, J., Khakoo, A. Y., Vaishnav, J., et al. (2021) · Circulation · doi:10.1161/circulationaha.120.050498 · Cited by 291
LeWinter, M. M., & Granzier, H. L. M. (2010) · Circulation · doi:10.1161/circulationaha.109.860171 · Cited by 260
Contractile Behavior of the Left Ventricle in Diastolic Heart Failure
Aurigemma, G. P., Zile, M. R., & Gaasch, W. H. (2006) · Circulation · doi:10.1161/circulationaha.104.481465 · Cited by 257
Falcão‐Pires, I., Hamdani, N., Borbély, A., Gavina, C., Schalkwijk, C. G., van der Velden, J., van Heerebeek, L., Stienen, G. J. M., Niessen, H. W. M., Leite-Moreira, A. F., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.025270 · Cited by 239
Treatment of Heart Failure With Normal Ejection Fraction
Paulus, W. J., & van Ballegoij, J. J. M. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.06.067 · Cited by 236
CMR-Verified Diffuse Myocardial Fibrosis Is Associated With Diastolic Dysfunction in HFpEF
Su, M.-Y. M., Lin, L., Tseng, Y., Chang, C., Wu, C., Lin, J.-L., & Tseng, W. I. (2014) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2014.04.022 · Cited by 230
Hamdani, N., Bishu, K. G., von Frieling-Salewsky, M., Redfield, M. M., & Linke, W. A. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs353 · Cited by 234
Heart failure with preserved ejection fraction
Gladden, J. D., Linke, W. A., & Redfield, M. M. (2014) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-014-1480-8 · Cited by 235
Ventricular–Vascular Interaction in Heart Failure
Borlaug, B. A., & Kass, D. A. (2011) · Cardiology Clinics · doi:10.1016/j.ccl.2011.06.004 · Cited by 225
Biological Phenotypes of Heart Failure With Preserved Ejection Fraction
Lewis, G. A., Schelbert, E. B., Williams, S. G., Cunnington, C., Ahmed, F. Z., McDonagh, T. A., & Miller, C. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.09.006 · Cited by 220
Manzano‐Fernández, S., Mueller, T., Pascual-Figal, D. A., Truong, Q. A., & Januzzi, J. L. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2010.09.011 · Cited by 209
Role of estrogen in diastolic dysfunction
Zhao, Z., Wang, H., Jessup, J. A., Lindsey, S. H., Chappell, M. C., & Groban, L. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00859.2013 · Cited by 209
Murine Models of Heart Failure With Preserved Ejection Fraction
Valero‐Muñoz, M., Backman, W., & Sam, F. (2017) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2017.07.013 · Cited by 217
Davis, B. R., Kostis, J. B., Simpson, L. M., Black, H. R., Cushman, W. C., Einhorn, P. T., Farber, M. A., Ford, C. E., Levy, D. A., Massie, B. M., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.762229 · Cited by 204
Heart failure with preserved ejection fraction: a clinical dilemma
Michel Komajda, N., & Lam, C. S. P. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu067 · Cited by 198
Current perspectives in diastolic dysfunction and diastolic heart failure
Leite-Moreira, A. F. (2006) · Heart · doi:10.1136/hrt.2005.062950 · Cited by 198
The physiological role of cardiac cytoskeleton and its alterations in heart failure
Sequeira, V., Nijenkamp, L. L. A. M., Regan, J. A., & van der Velden, J. (2013) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2013.07.011 · Cited by 198
Role of endothelial dysfunction in heart failure
Zuchi, C., Tritto, I., Carluccio, E., Mattei, C., Cattadori, G., & Ambrosio, G. (2019) · Heart Failure Reviews · doi:10.1007/s10741-019-09881-3 · Cited by 208
Hamdani, N., Krysiak, J., Kreußer, M. M., Neef, S., dos Remedios, C. G., Maier, L. S., Krüger, M., Backs, J., & Linke, W. A. (2013) · Circulation Research · doi:10.1161/circresaha.111.300105 · Cited by 186
Bishu, K. G., Hamdani, N., Mohammed, S. F., Krüger, M., Ohtani, T., Ogut, O., Brozovich, F. V., Burnett, J. C. J., Linke, W. A., & Redfield, M. M. (2011) · Circulation · doi:10.1161/circulationaha.111.048520 · Cited by 186
Rapid quantification of myocardial fibrosis: a new macro-based automated analysis
Hadi, A. M., Mouchaers, K. T. B., Schalij, I., Grünberg, K., Meijer, G. A., Noordegraaf, A. V., van der Laarse, W. J., & Beliën, J. A. M. (2011) · Cellular Oncology · doi:10.1007/s13402-011-0035-7 · Cited by 188
Heart Failure With Preserved Ejection Fraction
Loffredo, F. S., Nikolova, A., Pancoast, J. R., & Lee, R. T. (2014) · Circulation Research · doi:10.1161/circresaha.115.302929 · Cited by 184
Sarcomeric dysfunction in heart failure
Hamdani, N., Kooij, V., van Dijk, S. J., Merkus, D., Paulus, W. J., dos Remedios, C. G., Duncker, D. J., Stienen, G. J. M., & van der Velden, J. (2007) · Cardiovascular Research · doi:10.1093/cvr/cvm079 · Cited by 179
Heart failure with preserved ejection fraction
HAMO, C. E., DeJong, C., Hartshorne‐Evans, N., Lund, L. H., Shah, S. J., Solomon, S. D., & Lam, C. S. P. (2024) · Nature Reviews Disease Primers · doi:10.1038/s41572-024-00540-y · Cited by 197
Aoki, T., Fukumoto, Y., Sugimura, K., Oikawa, M., Satoh, K., Nakano, M., Nakayama, M., & Shimokawa, H. (2011) · Circulation Journal · doi:10.1253/circj.cj-11-0568 · Cited by 178
Mascherbauer, J., Marzluf, B. A., Tufaro, C., Pfaffenberger, S., Graf, A. C., Wexberg, P., Panzenboeck, A., Jakowitsch, J., Bangert, C., Laimer, D., et al. (2013) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.113.000633 · Cited by 175
Therapeutic targets for cardiac fibrosis: from old school to next-gen
Travers, J. G., Tharp, C. A., Rubino, M., & McKinsey, T. A. (2022) · Journal of Clinical Investigation · doi:10.1172/jci148554 · Cited by 179
Shinmura, K., Tamaki, K., Sano, M., Murata, M., Yamakawa, H., Ishida, H., & Fukuda, K. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.10.018 · Cited by 170
Williams, S. M., Golden‐Mason, L., Ferguson, B. S., Schuetze, K. B., Cavasin, M. A., Demos‐Davies, K., Yeager, M. E., Stenmark, K. R., & McKinsey, T. A. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.12.013 · Cited by 169
Passive Stiffness of Myocardium From Congenital Heart Disease and Implications for Diastole
Chaturvedi, R. R., Herron, T., Simmons, R., Shore, D., Kumar, P., Sethia, B., Chua, F., Vassiliadis, E., & Kentish, J. C. (2010) · Circulation · doi:10.1161/circulationaha.109.850677 · Cited by 167
Oxidative Stress as A Mechanism for Functional Alterations in Cardiac Hypertrophy and Heart Failure
Shah, A. K., Bhullar, S. K., Vijayan Elimban, A., & Dhalla, N. S. (2021) · Antioxidants · doi:10.3390/antiox10060931 · Cited by 166
Titin-based mechanical signalling in normal and failing myocardium
Krüger, M., & Linke, W. A. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.01.004 · Cited by 164
Rodriguez, M. L., Graham, B. T., Pabon, L., Han, S. J., Murry, C. E., & Sniadecki, N. J. (2014) · Journal of Biomechanical Engineering · doi:10.1115/1.4027145 · Cited by 167
Histone deacetylase activity governs diastolic dysfunction through a nongenomic mechanism
Jeong, M. Y., Lin, Y. H., Wennersten, S. A., Demos-Davies, K. M., Cavasin, M. A., Mahaffey, J. H., Monzani, V., Saripalli, C., Mascagni, P., Reece, T. B., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aao0144 · Cited by 163
Heart Failure With Preserved Ejection Fraction
Reddy, Y. N. V., & Borlaug, B. A. (2015) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2015.12.002 · Cited by 160
Myocardial hypertrophy and its role in heart failure with preserved ejection fraction
Heinzel, F. R., Hohendanner, F., Jin, G., Sedej, S., & Edelmann, F. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00374.2015 · Cited by 163
Cardiac Titin and Heart Disease
LeWinter, M. M., & Granzier, H. L. M. (2013) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000007 · Cited by 155
Rosch, S., Kresoja, K., Besler, C., Fengler, K., Schöber, A. R., von Roeder, M., Lücke, C., Gutberlet, M., Klingel, K., Thiele, H., et al. (2022) · Circulation · doi:10.1161/circulationaha.122.059280 · Cited by 157
Protein kinase-A phosphorylates titin in human heart muscle and reduces myofibrillar passive tension
Krüger, M., & Linke, W. A. (2006) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-006-9090-5 · Cited by 150
Heart Failure with Preserved Ejection Fraction: Uncertainties and Dilemmas
Ferrari, R., Böhm, M., Cleland, J. G. F., Paulus, W. J., Pieske, B. M., Rapezzi, C., & Tavazzi, L. (2015) · European Journal of Heart Failure · doi:10.1002/ejhf.304 · Cited by 150
Structure–function relations of the giant elastic protein titin in striated and smooth muscle cells
Granzier, H. L. M., & Labeit, S. (2007) · Muscle & Nerve · doi:10.1002/mus.20886 · Cited by 145
The Control of Diastolic Calcium in the Heart
Eisner, D. A., Caldwell, J. L., Trafford, A. W., & Hutchings, D. C. (2020) · Circulation Research · doi:10.1161/circresaha.119.315891 · Cited by 146
Selby, D. E., Palmer, B. M., LeWinter, M. M., & Meyer, M. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.10.069 · Cited by 137
Titin Is a Major Human Disease Gene
LeWinter, M. M., & Granzier, H. L. M. (2013) · Circulation · doi:10.1161/circulationaha.112.139717 · Cited by 138
Cardiac titin: Structure, functions and role in disease
LeWinter, M. M., Wu, Y., Labeit, S., & Granzier, H. L. M. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2006.06.035 · Cited by 136
Right Ventricular Myocardial Stiffness in Experimental Pulmonary Arterial Hypertension
Rain, S., Andersen, S., Najafi, A., Schultz, J. G., Bós, D. D. S. G., Handoko, M. L., Bogaard, H. J., Noordegraaf, A. V., Andersen, A., van der Velden, J., et al. (2016) · Circulation Heart Failure · doi:10.1161/circheartfailure.115.002636 · Cited by 138
Travers, J. G., Wennersten, S. A., Peña, B., Bagchi, R. A., Smith, H. E., Hirsch, R. A., Vanderlinden, L. A., Lin, Y., Dobrinskikh, E., Demos-Davies, K. M., et al. (2021) · Circulation · doi:10.1161/circulationaha.120.046462 · Cited by 132
Passive myocardial mechanical properties: meaning, measurement, models
Emig, R., Zgierski-Johnston, C. M., Timmermann, V., Taberner, A. J., Nash, M. P., Kohl, P. K., & Peyronnet, R. (2021) · Biophysical Reviews · doi:10.1007/s12551-021-00838-1 · Cited by 139
Molecular and Cellular Basis for Diastolic Dysfunction
van Heerebeek, L., Franssen, C., Hamdani, N., Verheugt, F. W. A., Somsen, G. A., & Paulus, W. J. (2012) · Current Heart Failure Reports · doi:10.1007/s11897-012-0109-5 · Cited by 123
van Dijk, S. J., Paalberends, E. R., Najafi, A., Michels, M., Sadayappan, S., Carrier, L., Boontje, N. M., Kuster, D. W. D., van Slegtenhorst, M., Dooijes, D., et al. (2012) · Circulation: Heart Failure · doi:10.1161/circheartfailure.111.963702 · Cited by 124
Self-citationNenadic, I., Urban, M. W., Mitchell, S. A., & Greenleaf, J. F. (2011) · Physics in Medicine and Biology · doi:10.1088/0031-9155/56/7/021 · Cited by 124
Biomarkers of Heart Failure with Normal Ejection Fraction: A Systematic Review
Cheng, J. M., Akkerhuis, K. M., Battes, L. C., van Vark, L. C., Hillege, H. L., Paulus, W. J., Boersma, E. H., & Kardys, I. (2013) · European Journal of Heart Failure · doi:10.1093/eurjhf/hft106 · Cited by 121
Diastolic heart failure: mechanisms and controversies
Ouzounian, M., Lee, D. S., & Liu, P. P. (2008) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio1245 · Cited by 121
Tuning the molecular giant titin through phosphorylation: Role in health and disease
Hidalgo, C. G., & Granzier, H. L. M. (2013) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2012.10.005 · Cited by 121
A novel mechanism of heart failure with normal ejection fraction
MacIver, D. H., & Townsend, M. (2007) · Heart · doi:10.1136/hrt.2006.114082 · Cited by 120
González, A., López, B., Querejeta, R., Zubillaga, E., Echeverría, T., & Dı́ez, J. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.149112 · Cited by 119
Methawasin, M., Strom, J. G., Slater, R. E., Fernandez, V., Saripalli, C., & Granzier, H. L. M. (2016) · Circulation · doi:10.1161/circulationaha.116.023003 · Cited by 120
In Vivo Assessment of Myocardial Stiffness with Acoustic Radiation Force Impulse Imaging
Hsu, S. J., Bouchard, R. R., Dumont, D. M., Wolf, P. D., & Trahey, G. E. (2007) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2007.05.009 · Cited by 119
Sarcomeric protein isoform transitions in cardiac muscle: A journey to heart failure
Yin, Z., Ren, J. T., & Guo, W. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.11.003 · Cited by 115
Runte, K. E., Bell, S. P., Selby, D. E., Häußler, T. N., Ashikaga, T., LeWinter, M. M., Palmer, B. M., & Meyer, M. (2017) · Circulation Heart Failure · doi:10.1161/circheartfailure.117.004311 · Cited by 116
Chronic low‐grade inflammation in heart failure with preserved ejection fraction
Mesquita, T., Lin, Y., & Ibrahim, A. G.-E. (2021) · Aging Cell · doi:10.1111/acel.13453 · Cited by 118
Cardiac Disorders and Pathophysiology of Sarcomeric Proteins
van der Velden, J., & Stienen, G. J. M. (2018) · Physiological Reviews · doi:10.1152/physrev.00040.2017 · Cited by 117
Therapeutic approaches in heart failure with preserved ejection fraction: past, present, and future
Wintrich, J., Kindermann, I., Ukena, C., Selejan, S., Werner, C. M., Maack, C., Laufs, U., Tschöpe, C., Anker, S. D., Lam, C. S. P., et al. (2020) · Clinical Research in Cardiology · doi:10.1007/s00392-020-01633-w · Cited by 106
Ultrafast Ultrasound Imaging in Pediatric and Adult Cardiology
Villemain, O., Baranger, J., Friedberg, M. K., Papadacci, C., Dizeux, A., Messas, E., Tanter, M., Pernot, M., & Mertens, L. (2019) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2019.09.019 · Cited by 104
Heart failure with preserved ejection fraction: Refocusing on diastole
Abbate, A., Arena, R. A., Abouzaki, N. A., Tassell, B. W. V., Canada, J. M., Shah, K. B., Biondi‐Zoccai, G., & Voelkel, N. F. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.11.106 · Cited by 104
Heart Failure with Preserved Ejection Fraction: Persistent Diagnosis, Therapeutic Enigma
Bhuiyan, T., & Maurer, M. S. (2011) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-011-0184-2 · Cited by 102
Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy
Beverborg, N. G., Später, D., Knöll, R., Hidalgo, A., Yeh, S. T., Elbeck, Z., Silljé, H. H. W., Eijgenraam, T. R., Siga, H., Zurek, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25439-0 · Cited by 102
Raskin, A., Lange, S., Banares, K., Lyon, R. C., Zieseniß, A., Lee, L. K., Yamazaki, K. G., Granzier, H. L. M., Gregorio, C. C., McCulloch, A. D., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.372839 · Cited by 98
Cardiac Fibrosis in the Pressure Overloaded Left and Right Ventricle as a Therapeutic Target
Schimmel, K., Ichimura, K., Reddy, S., Haddad, F., & Spiekerkoetter, E. F. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.886553 · Cited by 106
Cardiac function and modulation of sarcomeric function by length
Hanft, L. M., Korte, F. S., & McDonald, K. S. (2007) · Cardiovascular Research · doi:10.1093/cvr/cvm099 · Cited by 96
Metadata
- Authors
- Borbély, A., van der Velden, J., Papp, Z., Bronzwaer, J. G. F., Edes, I., Stienen, G. J. M., & Paulus, W. J.
- Affiliations
- From the Laboratory for Physiology (A.B., J.v.d.V., J.G.F.B., G.J.M.S., W.J.P.), Institute for Cardiovascular Research, VUMC, Amsterdam, the Netherlands, and the Division of Clinical Physiology (A.B., Z.P., I.E.), Institute of Cardiology, UDMHSC, Debrecen, Hungary.
- Amsterdam Cardiovascular Sciences (NL)
- Venue
- Circulation
- Published
- 2005-02-15
- Volume
- 111
- Issue
- 6
- Pages
- 774-781
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2140058582
- Cited by
- 536
- References
- 44
- Citations by year
- 2026: 13 · 2025: 19 · 2024: 21 · 2023: 24 · 2022: 25 · 2021: 28 · 2020: 37 · 2019: 20 · 2018: 28 · 2017: 32 · 2016: 35 · 2015: 30 · 2014: 35 · 2013: 24 · 2012: 20
- FWCI
- 14.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion, other-oa)
- Pure Amsterdam UMC (submittedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Keywords
- heart failure with preserved ejection fraction, cardiomyocyte stiffness, passive tension, collagen volume fraction, sarcomeric proteins, protein kinase A, sarcomere length, diastolic dysfunction, left ventricular end-diastolic pressure, myocardial fibrosis
- MeSH terms
- Aged, Aged, 80 and over, Calcium, Diastole, Female, Heart Failure, Hemodynamics, Humans, Male, Middle Aged, Myocardium, Stroke Volume, Ventricular Function, Left, Ventricular Pressure, Cyclic AMP-Dependent Protein Kinases, Myocytes, Cardiac
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
