The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Elevated HDL Cholesterol Is a Risk Factor for Ischemic Heart Disease in White Women When Caused by a Common Mutation in the Cholesteryl Ester Transfer Protein Gene
Open accessAbstract
Background —The level of HDL cholesterol is inversely related to the risk of ischemic heart disease. Methods and Results —In 9168 women and men from a general population and 946 women and men with ischemic heart disease (all white), we tested the hypothesis that the Ile405Val mutation in the cholesteryl ester transfer protein gene ( CETP ) affects HDL cholesterol levels and the risk of ischemic heart disease. The relative frequencies of Ile/Ile, Ile/Val, and Val/Val carriers were 0.46, 0.43, and 0.11 for both women and men. Women with these 3 genotypes had mean HDL cholesterol levels of 1.68, 1.75, and 1.82 mmol/L, respectively ( P <0.001, ANOVA), as well as a significant decrease in the ratio of total to HDL cholesterol ( P =0.002, ANOVA). On multiple logistic regression analysis, women not treated with hormone replacement therapy who were heterozygous or homozygous for Val405 had a 1.4-fold (95% CI 1.0 to 1.9) to 2.1-fold (95% CI 1.3 to 3.4) increase in the risk of ischemic heart disease. No significant associations were found in men. Conclusions —Increased HDL cholesterol levels caused by mutations in CETP are associated with an increased risk of ischemic heart disease in white women.
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Cited by
Nordestgaard, B. G., Benn, M., Schnohr, P., & Tybjærg-Hansen, A. (2007) · JAMA · doi:10.1001/jama.298.3.299 · Cited by 2,058
Self-citationTriglycerides and cardiovascular disease
Nordestgaard, B. G., & Varbo, A. (2014) · The Lancet · doi:10.1016/s0140-6736(14)61177-6 · Cited by 1,419
Self-citationNordestgaard, B. G. (2016) · Circulation Research · doi:10.1161/circresaha.115.306249 · Cited by 1,116
Self-citationCholesteryl Ester Transfer Protein: A Novel Target for Raising HDL and Inhibiting Atherosclerosis
Barter, P. J., Brewer, H. B., Chapman, M. J., Hennekens, C. H., Rader, D. J., & Tall, A. R. (2003) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000054658.91146.64 · Cited by 870
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Metadata
- Authors
- Agerholm-Larsen, B., Nordestgaard, B. G., Steffensen, R., Jensen, G., & Tybjærg-Hansen, A.
- Venue
- Circulation
- Published
- 2000-04-25
- Volume
- 101
- Issue
- 16
- Pages
- 1907-1912
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2002081006
- Cited by
- 267
- References
- 36
- FWCI
- 19.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Agerholm-Larsen, B., Nordestgaard, B. G., Steffensen, R., Jensen, G., & Tybjærg-Hansen, A. (2000). Elevated HDL Cholesterol Is a Risk Factor for Ischemic Heart Disease in White Women When Caused by a Common Mutation in the Cholesteryl Ester Transfer Protein Gene. Circulation. https://doi.org/10.1161/01.cir.101.16.1907
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