The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
PTX3, A Prototypical Long Pentraxin, Is an Early Indicator of Acute Myocardial Infarction in Humans
Abstract
Background —Inflammation is an important component of ischemic heart disease. PTX3 is a long pentraxin whose expression is induced by cytokines in endothelial cells, mononuclear phagocytes, and myocardium. The possibility that PTX3 is altered in patients with acute myocardial infarction (AMI) has not yet been tested. Methods and Results —Blood samples were collected from 37 patients admitted to the coronary care unit (CCU) with symptoms of AMI. PTX3 plasma concentrations, as measured by ELISA, higher than the mean+2 SD of age-matched controls (2.01 ng/mL) were found in 27 patients within the first 24 hours of CCU admission. PTX3 peaked at 7.5 hours after CCU admission, and mean peak concentration was 6.94±11.26 ng/mL. Plasma concentrations of PTX3 returned to normal in all but 3 patients at hospital discharge and were unrelated to AMI site or extent, Killip class at entry, hours from symptom onset, and thrombolysis. C-reactive protein peaked in plasma at 24 hours after CCU admission, much later than PTX3 ( P <0.001). Patients >64 years old and women had significantly higher PTX3 concentrations at 24 hours ( P <0.05). PTX3 was detected by immunohistochemistry in normal but not in necrotic myocytes. Conclusions —PTX3 is present in the intact myocardium, increases in the blood of patients with AMI, and disappears from damaged myocytes. We suggest that PTX3 is an early indicator of myocyte irreversible injury in ischemic cardiomyopathy.
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Cites
Acute-Phase Proteins and Other Systemic Responses to Inflammation
Gabay, C., & Kushner, I. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902113400607 · Cited by 6,734
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
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The Prognostic Value of C-Reactive Protein and Serum Amyloid A Protein in Severe Unstable Angina
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Production of C-reactive protein and risk of coronary events in stable and unstable angina
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The heart and cardiovascular system
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Inflammation, Atherosclerosis, and Coronary Artery Disease
Hansson, G. K. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043430 · Cited by 8,773
Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity
Mantovani, A., Dinarello, C. A., Molgora, M., & Garlanda, C. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.012 · Cited by 1,046
Self-citationINFLAMMATION AND ATHEROSCLEROSIS
Hansson, G. K., Robertson, A.-K. L., & Söderberg-Nauclér, C. (2006) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.1.110304.100100 · Cited by 1,046
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Self-citationNon-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response
Garlanda, C., Hirsch, E., Bozza, S., Salustri, A., De Acetis, M., Nota, R., Maccagno, A., Riva, F., Bottazzi, B., Peri, G., et al. (2002) · Nature · doi:10.1038/nature01195 · Cited by 669
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Metadata
- Authors
- Peri, G., Introna, M., Corradi, D., Iacuitti, G., Signorini, S., Avanzini, F., Pizzetti, F., Maggioni, A. P., Moccetti, T., Metra, M., Cas, L. D., Ghezzi, P., Sipe, J. D., Re, G., Olivetti, G., Mantovani, A., & Latini, R.
- Venue
- Circulation
- Published
- 2000-08-08
- Volume
- 102
- Issue
- 6
- Pages
- 636-641
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1993215640
- Cited by
- 425
- References
- 30
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- Peri, G., Introna, M., Corradi, D., Iacuitti, G., Signorini, S., Avanzini, F., Pizzetti, F., Maggioni, A. P., Moccetti, T., Metra, M., Cas, L. D., Ghezzi, P., Sipe, J. D., Re, G., Olivetti, G., Mantovani, A., & Latini, R. (2000). PTX3, A Prototypical Long Pentraxin, Is an Early Indicator of Acute Myocardial Infarction in Humans. Circulation. https://doi.org/10.1161/01.cir.102.6.636
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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