The DOI matches its Crossref record; 128 of the 128 references it cites were found in a registry or an index.
PENTRAXINS AT THE CROSSROADS BETWEEN INNATE IMMUNITY, INFLAMMATION, MATRIX DEPOSITION, AND FEMALE FERTILITY
Abstract
▪ Abstract C reactive protein, the first innate immunity receptor identified, and serum amyloid P component are classic short pentraxins produced in the liver. Long pentraxins, including the prototype PTX3, are expressed in a variety of tissues. Some long pentraxins are expressed in the brain and some are involved in neuronal plasticity and degeneration. PTX3 is produced by a variety of cells and tissues, most notably dendritic cells and macrophages, in response to Toll-like receptor (TLR) engagement and inflammatory cytokines. PTX3 acts as a functional ancestor of antibodies, recognizing microbes, activating complement, and facilitating pathogen recognition by phagocytes, hence playing a nonredundant role in resistance against selected pathogens. In addition, PTX3 is essential in female fertility because it acts as a nodal point for the assembly of the cumulus oophorus hyaluronan-rich extracellular matrix. Thus, the prototypic long pentraxin PTX3 is a multifunctional soluble pattern recognition receptor at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility.
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Cites
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Self-citationToll-like receptors and innate immunity
Medzhitov, R. (2001) · Nature Reviews Immunology · doi:10.1038/35100529 · Cited by 4,308
C-reactive protein: a critical update
Pepys, M. B., & Hirschfield, G. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18921 · Cited by 3,503
C-reactive protein: a critical update
Pepys, M. B., & Hirschfield, G. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318921 · Cited by 3,436
Serological reactions in pneumonia with a non-protein somatic fraction of Pneumococcus
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Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response
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Self-citationParacrine Actions Of Growth Differentiation Factor-9 in the Mammalian Ovary
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Diversity, Mechanisms, and Significance of Macrophage Plasticity
Locati, M., Curtale, G., & Mantovani, A. (2020) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012418-012718 · Cited by 2,199
Self-citationThe human heart contains distinct macrophage subsets with divergent origins and functions
Bajpai, G., Schneider, C., Wong, N., Bredemeyer, A., Hulsmans, M., Nahrendorf, M., Epelman, S., Kreisel, D., Liu, Y., Itoh, A., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0059-x · Cited by 712
An Integrated View of Humoral Innate Immunity: Pentraxins as a Paradigm
Bottazzi, B., Doni, A., Garlanda, C., & Mantovani, A. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101305 · Cited by 592
Self-citationMacrophage Diversity and Polarization in Atherosclerosis: A Question of Balance
Mantovani, A., Garlanda, C., & Locati, M. (2009) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.180497 · Cited by 426
Self-citationPTX3 Is an Extrinsic Oncosuppressor Regulating Complement-Dependent Inflammation in Cancer
Bonavita, E., Gentile, S., Rubino, M., Maina, V., Papait, R., Kunderfranco, P., Greco, C., Feruglio, F., Molgora, M., Laface, I., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.004 · Cited by 417
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Metadata
- Authors
- Garlanda, C., Bottazzi, B., Bastone, A., & Mantovani, A.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2005-04-01
- Volume
- 23
- Issue
- 1
- Pages
- 337-366
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2144648204
- Cited by
- 836
- References
- 128
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- Garlanda, C., Bottazzi, B., Bastone, A., & Mantovani, A. (2005). PENTRAXINS AT THE CROSSROADS BETWEEN INNATE IMMUNITY, INFLAMMATION, MATRIX DEPOSITION, AND FEMALE FERTILITY. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.23.021704.115756
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