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Elevated C-Reactive Protein Levels and Impaired Endothelial Vasoreactivity in Patients With Coronary Artery Disease
Open accessAbstract
Background —Elevated C-reactive protein (CRP) serum levels, an exquisitely sensitive objective marker of inflammation, relate to long-term prognosis in patients with coronary artery disease and in apparently healthy men. Because abnormalities of endothelial regulation of vascular function may contribute to the occurrence of coronary events, we tested the hypothesis that elevated CRP levels are associated with an abnormal systemic endothelial vascular reactivity. Methods and Results —Endothelium-dependent (10 to 50 μg/min acetylcholine) and endothelium-independent (2 to 8 μg/min sodium nitroprusside) forearm blood flow responses were measured with venous occlusion plethysmography in 60 male patients with angiographically documented coronary artery disease. Forearm blood flow responses to acetylcholine were inversely correlated with CRP serum levels ( r =−0.46, P =0.001). With multivariate analysis that included the classic risk factors for coronary artery disease, elevated CRP serum level remained a statistically significant independent predictor of a blunted endothelial vasodilator capacity. Most important, normalization of elevated CRP levels over time was associated with a normalization of endothelium-mediated forearm blood flow responses after 3 months. Conclusions —Thus, elevated CRP serum levels indicative of a systemic inflammatory response are associated with a blunted systemic endothelial vasodilator function. The identification of elevated CRP levels as a transient independent risk factor for endothelial dysfunction might provide an important clue to link a systemic marker of inflammation to atherosclerotic disease progression.
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Khazova, E. V., & Bulashova, O. V. (2021) · Kazan medical journal · doi:10.17816/kmj2021-510 · Cited by 6
Osteopontin a new probable marker for atherosclerosis in obese women
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“In cardiovascular events CRP has been shown to be a marker of the degree of inflammatory activity and a valuable tool for the risk assessment (Fichtschere et al., 2000).”
BackgroundMethodStrauss‐Kruger, M., Smith, W. T., & Schutte, A. E. (2016) · Heart Lung and Circulation · doi:10.1016/j.hlc.2016.01.019 · Cited by 6
“Endothelial dysfunction [18] as well as IASBPD [19] have been linked to elevated C-reactive protein (CRP) levels, a potential predictor of an increased risk for PVD [20].”
BackgroundCoronary Endothelial Dysfunction, Obesity and Metabolic Syndrome
Quyyumi, A. A. (2014) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000362 · Cited by 6
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Inflammasjon og C-reaktivt protein ved hjerte- og karsykdom
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“It has been shown that CRP can activate complement and is associated with impaired systemic endothelial vascular reactivity in patients with CAV as well as in patients with native atherosclerosis [17, 20, 21].”
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Association of IGF-1 with Coronary Collateral Circulation in Stable Coronary Artery Disease
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Akutes Koronarsyndrom und Entz�ndung
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“Eigene Untersuchungen zeigen den engen Zusammenhang zwischen ACS, erhöhten CRP-Spiegeln sowie einer eingeschränkten endothelabhängigen Gefäßregulation [30, 31], die als solches auch bei Patienten mit ACS ein unabhängiger Prädiktor für zukünftige kardiovaskuläre Ereignisse ist [28].”
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Schwartz, R. G. (2001) · Journal of Nuclear Cardiology · doi:10.1067/mnc.2001.116847 · Cited by 6
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“Systemic inflammation could also impair endothelial function and muscle perfusion, disrupts the uptake of branched-chain amino acids, and consequently reduces muscle energy production and protein synthesis [39].”
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“La proteína C reactiva ultrasensible (PCR-us) es un reactante de fase aguda que ha demostrado aso-ciación con la placa ateromatosa 12 y la disfunción endotelial 13 .”
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Platelets in the pathogenesis of vascular disease and their role as a therapeutic target
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“[35,36] Though studies have documented a direct correlation between serum PRL and decreased FMD, [15,16] no significant correlation was observed between serum PRL and EnD markers in the current study.”
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“For example, hyperhomocysteinemia or elevated C-reactive protein levels have shown to inhibit peripheral arterial vasoreactivity (37, 38) but were not tested in this patient population.”
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Cardiovascular Risk in Hashimoto\'s Thyroiditis: Role of Thyroid Autoimmunity
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Metadata
- Authors
- Fichtlscherer, S., Rosenberger, G., Walter, D. H., Breuer, S., Dimmeler, S., & Zeiher, A. M.
- Affiliations
- Goethe University Frankfurt (DE)
- Venue
- Circulation
- Published
- 2000-08-29
- Volume
- 102
- Issue
- 9
- Pages
- 1000-1006
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2076633296
- Cited by
- 665
- References
- 25
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 8 · 2022: 9 · 2021: 14 · 2020: 11 · 2019: 11 · 2018: 17 · 2017: 16 · 2016: 18 · 2015: 18 · 2014: 26 · 2013: 27 · 2012: 21
- FWCI
- 23.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- C-reactive protein, coronary artery disease, endothelial dysfunction, endothelium-dependent vasodilation, acetylcholine response, forearm blood flow, systemic inflammation, cardiovascular risk factors, atherosclerosis, sodium nitroprusside
- MeSH terms
- Acetylcholine, Adrenergic beta-Antagonists, Aspirin, Brachial Artery, C-Reactive Protein, Coronary Disease, Endothelium, Vascular, Follow-Up Studies, Forearm, Humans, Inflammation, Infusions, Intra-Arterial, Male, Middle Aged, Nitroprusside, Regional Blood Flow, Risk Factors, Vasodilation, Vasodilator Agents, Biomarkers, Multivariate Analysis
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