The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Randomized, Single-Blind, Placebo-Controlled Pilot Study of Catheter-Based Myocardial Gene Transfer for Therapeutic Angiogenesis Using Left Ventricular Electromechanical Mapping in Patients With Chronic Myocardial Ischemia
Open accessAbstract
Background —Catheter-based myocardial gene transfer (GTx) has not been previously tested in human subjects. Accordingly, we performed a pilot study to investigate the feasibility and safety of catheter-based myocardial GTx of naked plasmid DNA encoding vascular endothelial growth factor-2 (phVEGF-2) in patients with chronic myocardial ischemia. Methods and Results —A steerable, deflectable 8F catheter incorporating a 27-guage needle was advanced percutaneously to the left ventricular myocardium of 6 patients with chronic myocardial ischemia. Patients were randomized (1:1) to receive phVEGF-2 (total dose, 200 μg), which was administered as 6 injections into ischemic myocardium (total, 6.0 mL), or placebo (mock procedure). Injections were guided by NOGA left ventricular electromechanical mapping. Patients initially randomized to placebo became eligible for phVEGF-2 GTx if they had no clinical improvement 90 days after their initial procedure. Catheter injections (n=36) caused no changes in heart rate or blood pressure. No sustained ventricular arrhythmias, ECG evidence of infarction, or ventricular perforations were observed. phVEGF-2–transfected patients experienced reduced angina (before versus after GTx, 36.2±2.3 versus 3.5±1.2 episodes/week) and reduced nitroglycerin consumption (33.8±2.3 versus 4.1±1.5 tablets/week) for up to 360 days after GTx; reduced ischemia by electromechanical mapping (mean area of ischemia, 10.2±3.5 versus 2.8±1.6 cm 2 , P =0.04); and improved myocardial perfusion by SPECT-sestamibi scanning for up to 90 days after GTx when compared with images obtained after control procedure. Conclusions —This randomized trial of catheter-based phVEGF-2 myocardial GTx provides preliminary indications regarding the feasibility, safety, and potential efficacy of percutaneous myocardial GTx to human left ventricular myocardium.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Baumgartner, I., Pieczek, A., Manor, O., Blair, R., Kearney, M., Walsh, K., & Isner, J. M. (1998) · Circulation · doi:10.1161/01.cir.97.12.1114 · Cited by 1,098
Self-citationGepstein, L., Hayam, G., & Ben-Haim, S. A. (1997) · Circulation · doi:10.1161/01.cir.95.6.1611 · Cited by 759
Giordano, F. J., Ping, P., McKirnan, M. D., Nozaki, S., Demaria, A. N., Dillmann, W. H., Mathieu-Costello, O., & Hammond, H. K. (1996) · Nature Medicine · doi:10.1038/nm0596-534 · Cited by 486
Isner, J. M., Baumgartner, I., Rauh, G., Schainfeld, R., Blair, R., Manor, O., Razvi, S., & Symes, J. F. (1998) · Journal of Vascular Surgery · doi:10.1016/s0741-5214(98)70022-9 · Cited by 392
Self-citationTsurumi, Y., Takeshita, S., Chen, D., Kearney, M., Rossow, S. T., Passeri, J., Horowitz, J. R., Symes, J. F., & Isner, J. M. (1996) · Circulation · doi:10.1161/01.cir.94.12.3281 · Cited by 389
Self-citationFrazier, O. H., March, R. J., & Horvath, K. A. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909303411402 · Cited by 373
Nonfluoroscopic, in vivo navigation and mapping technology
Ben-Haim, S. A., Osadchy, D., Scnuster, I., Gepstein, L., Hayam, G., & Josephson, M. E. (1996) · Nature Medicine · doi:10.1038/nm1296-1393 · Cited by 370
Allen, K. B., Dowling, R. D., Fudge, T. L., Schoettle, G. P., Selinger, S. L., Gangahar, D. M., Angell, W. W., Petracek, M. R., Shaar, C. J., & O’Neill, W. W. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909303411403 · Cited by 364
Vale, P. R., Losordo, D. W., Milliken, C. E., Maysky, M., Esakof, D. D., Symes, J. F., & Isner, J. M. (2000) · Circulation · doi:10.1161/01.cir.102.9.965 · Cited by 318
Self-citationGermano, G., Erel, J., Lewin, H., Kavanagh, P. B., & Berman, D. S. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00276-3 · Cited by 315
Cited by
Vascular Endothelial Growth Factor and Angiogenesis
Hoeben, A., Landuyt, B., Highley, M. S., Wildiers, H., Van Oosterom, A. T., & De Bruijn, E. A. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.4.3 · Cited by 1,824
Tse, H.-F., Kwong, Y.-L., Chan, J. K., Lo, G., Ho, C.-L., & Lau, C.-P. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12111-3 · Cited by 850
Vascular Endothelial Growth Factors
Ylä-Herttuala, S., Rissanen, T. T., Vajanto, I., & Hartikainen, J. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.09.053 · Cited by 480
Losordo, D. W., Vale, P. R., Hendel, R. C., Milliken, C. E., Fortuin, F. D., Cummings, N., Schatz, R. A., Asahara, T., Isner, J. M., & Kuntz, R. E. (2002) · Circulation · doi:10.1161/01.cir.0000015982.70785.b7 · Cited by 466
Self-citationKusano, K. F., Pola, R., Murayama, T., Curry, C., Kawamoto, A., Iwakura, A., Shintani, S., Ii, M., Asai, J., Tkebuchava, T., et al. (2005) · Nature Medicine · doi:10.1038/nm1313 · Cited by 304
Self-citation
Metadata
- Authors
- Vale, P. R., Losordo, D. W., Milliken, C. E., McDonald, M. C., Gravelin, L. M., Curry, C. M., Esakof, D. D., Maysky, M., Symes, J. F., & Isner, J. M.
- Venue
- Circulation
- Published
- 2001-05
- Volume
- 103
- Issue
- 17
- Pages
- 2138-2143
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1993966328
- Cited by
- 307
- References
- 12
- FWCI
- 32.29
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Randomized, Single-Blind, Placebo-Controlled Pilot Study of Catheter-Based Myocardial Gene Transfer for Therapeutic Angiogenesis Using Left Ventricular Electromechanical Mapping in Patients With Chronic Myocardial Ischemia. https://app.cochat.ai/papers/10.1161/01.cir.103.17.2138
- The paper
- Vale, P. R., Losordo, D. W., Milliken, C. E., McDonald, M. C., Gravelin, L. M., Curry, C. M., Esakof, D. D., Maysky, M., Symes, J. F., & Isner, J. M. (2001). Randomized, Single-Blind, Placebo-Controlled Pilot Study of Catheter-Based Myocardial Gene Transfer for Therapeutic Angiogenesis Using Left Ventricular Electromechanical Mapping in Patients With Chronic Myocardial Ischemia. Circulation. https://doi.org/10.1161/01.cir.103.17.2138
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
