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Cited by 938

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Intracoronary Stenting and Angiographic Results: Strut Thickness Effect on Restenosis Outcome (ISAR-STEREO) Trial

Open access
Kastrati, Adnan, Mehilli, Julinda, Dirschinger, Josef, Dotzer, Franz, Schühlen, Helmut, Neumann, Franz-Josef, Fleckenstein, Martin, Pfafferott, Conrad, Seyfarth, Melchior, Schömig, Albert·2001·Circulation

Abstract

Background —Increased thrombogenicity and smooth muscle cell proliferative response induced by the metal struts compromise the advantages of coronary stenting. The objective of this randomized, multicenter study was to assess whether a reduced strut thickness of coronary stents is associated with improved follow-up angiographic and clinical results. Methods and Results —A total of 651 patients with coronary lesions situated in native vessels >2.8 mm in diameter were randomly assigned to receive 1 of 2 commercially available stents of comparable design but different thickness: 326 patients to the thin-strut stent (strut thickness of 50 μm) and 325 patients to the thick-strut stent (strut thickness of 140 μm). The primary end point was the angiographic restenosis (≥50% diameter stenosis at follow-up angiography). Secondary end points were the incidence of reinterventions due to restenosis-induced ischemia and the combined rate of death and myocardial infarctions at 1 year. The incidence of angiographic restenosis was 15.0% in the thin-strut group and 25.8% in the thick-strut group (relative risk, 0.58; 95% CI, 0.39 to 0.87; P =0.003). Clinical restenosis was also significantly reduced, with a reintervention rate of 8.6% among thin-strut patients and 13.8% among thick-strut patients (relative risk, 0.62; 95% CI, 0.39 to 0.99; P =0.03). No difference was observed in the combined 1-year rate of death and myocardial infarction. Conclusions —The use of a thinner-strut device is associated with a significant reduction of angiographic and clinical restenosis after coronary artery stenting. These findings may have relevant implications for the currently most widely used percutaneous coronary intervention.

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Crossref · 10.1161/01.cir.103.23.2816

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Metadata

Authors
Kastrati, A., Mehilli, J., Dirschinger, J., Dotzer, F., Schühlen, H., Neumann, F.-J., Fleckenstein, M., Pfafferott, C., Seyfarth, M., & Schömig, A.
Venue
Circulation
Published
2001-06-12
Volume
103
Issue
23
Pages
2816-2821
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
OpenAlex
W2107406419
Cited by
938
References
15
FWCI
26.70
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Intracoronary Stenting and Angiographic Results: Strut Thickness Effect on Restenosis Outcome (ISAR-STEREO) Trial. https://app.cochat.ai/papers/10.1161/01.cir.103.23.2816
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Kastrati, A., Mehilli, J., Dirschinger, J., Dotzer, F., Schühlen, H., Neumann, F.-J., Fleckenstein, M., Pfafferott, C., Seyfarth, M., & Schömig, A. (2001). Intracoronary Stenting and Angiographic Results: Strut Thickness Effect on Restenosis Outcome (ISAR-STEREO) Trial. Circulation. https://doi.org/10.1161/01.cir.103.23.2816

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