The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Tissue Doppler Imaging Consistently Detects Myocardial Abnormalities in Patients With Hypertrophic Cardiomyopathy and Provides a Novel Means for an Early Diagnosis Before and Independently of Hypertrophy
Open accessAbstract
Background — Left ventricular hypertrophy (LVH), the clinical hallmark of familial hypertrophic cardiomyopathy (FHCM), is absent in a significant number of subjects with causal mutations. In transgenic rabbits that fully recapitulate the FHCM phenotype, reduced myocardial tissue Doppler (TD) velocities accurately identified the mutant rabbits, even in the absence of LVH. We tested whether humans with FHCM also consistently showed reduced myocardial TD velocities, irrespective of LVH. Methods and Results — We performed 2D and Doppler echocardiography and TD imaging in 30 subjects with FHCM, 13 subjects who were positive for various mutations but did not have LVH, and 30 age- and sex-matched controls (all adults; 77% women). LV wall thickness and mass were significantly greater in FHCM subjects ( P <0.01 versus those without LVH and controls). There were no significant differences in 2D echocardiographic, mitral, and pulmonary venous flow indices between mutation-positives without LVH and controls. In contrast, systolic and early diastolic TD velocities were significantly lower in both mutation-positives without LVH and in FHCM patients than in controls ( P <0.001). Reduced TD velocities had a sensitivity of 100% and a specificity of 93% for identifying mutation-positives without LVH. Conclusions — Myocardial contraction and relaxation velocities, detected by TD imaging, are reduced in FHCM, including in those without LVH. Before and independently of LVH, TD imaging is an accurate and sensitive method for identifying subjects who are positive for FHCM mutations.
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Cites
Recommendations for Quantitation of the Left Ventricle by Two-Dimensional Echocardiography
Schiller, N. B., Shah, P. M., Crawford, M., DeMaria, A., Devereux, R., Feigenbaum, H., Gutgesell, H., Reichek, N., Sahn, D., Schnittger, I., et al. (1989) · Journal of the American Society of Echocardiography · doi:10.1016/s0894-7317(89)80014-8 · Cited by 8,121
Sudden Death in Young Competitive Athletes: Clinical, Demographic, and Pathological Profiles
Maron, B. J. (1996) · JAMA · doi:10.1001/jama.1996.03540030033028 · Cited by 1,693
Niimura, H., Bachinski, L. L., Sangwatanaroj, S., Watkins, H., Chudley, A. E., McKenna, W., Kristinsson, A., Roberts, R., Sole, M., Maron, B. J., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199804303381802 · Cited by 761
Self-citationNagueh, S. F., Lakkis, N. M., Middleton, K. J., Spencer, W. H., Zoghbi, W. A., & Quiñones, M. A. (1999) · Circulation · doi:10.1161/01.cir.99.2.254 · Cited by 530
Self-citationThe Molecular Genetic Basis for Hypertrophic Cardiomyopathy
Marian, A. J., & Roberts, R. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1340 · Cited by 438
Self-citationLim, D.-S., Lutucuta, S., Bachireddy, P., Youker, K., Evans, A., Entman, M., Roberts, R., & Marian, A. J. (2001) · Circulation · doi:10.1161/01.cir.103.6.789 · Cited by 386
Self-citationPathogenesis of diverse clinical and pathological phenotypes in hypertrophic cardiomyopathy
Marian, A. (2000) · The Lancet · doi:10.1016/s0140-6736(99)06187-5 · Cited by 235
Self-citationA transgenic rabbit model for human hypertrophic cardiomyopathy
Marian, A. J., Wu, Y., Lim, D.-S., McCluggage, M., Youker, K., Yu, Q.-T., Brugada, R., DeMayo, F., Quinones, M., & Roberts, R. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7956 · Cited by 181
Self-citationNagueh, S. F., Kopelen, H. A., Lim, D.-S., Zoghbi, W. A., Quiñones, M. A., Roberts, R., & Marian, A. J. (2000) · Circulation · doi:10.1161/01.cir.102.12.1346 · Cited by 171
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2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy
Authors/Task Force members, Elliott, P. M., Anastasakis, A., Borger, M. A., Borggrefe, M., Cecchi, F., Charron, P., Hagege, A. A., Lafont, A., Limongelli, G., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu284 · Cited by 4,332
Hypertrophic Cardiomyopathy: A Systematic Review
Maron, B. J. (2002) · JAMA · doi:10.1001/jama.287.10.1308 · Cited by 2,224
Hypertrophic Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy
Marian, A. J., & Braunwald, E. (2017) · Circulation Research · doi:10.1161/circresaha.117.311059 · Cited by 1,403
Self-citationEzekowitz, J. A., O'Meara, E., McDonald, M. A., Abrams, H., Chan, M., Ducharme, A., Giannetti, N., Grzeslo, A., Hamilton, P. G., Heckman, G. A., et al. (2017) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2017.08.022 · Cited by 676
A Clinician’s Guide to Tissue Doppler Imaging
Ho, C. Y., & Solomon, S. D. (2006) · Circulation · doi:10.1161/circulationaha.105.579268 · Cited by 359
Metadata
- Authors
- Nagueh, S. F., Bachinski, L. L., Meyer, D., Hill, R., Zoghbi, W. A., Tam, J. W., Quiñones, M. A., Roberts, R., & Marian, A. J.
- Venue
- Circulation
- Published
- 2001-07-10
- Volume
- 104
- Issue
- 2
- Pages
- 128-130
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2130211781
- Cited by
- 616
- References
- 9
- FWCI
- 20.18
- Type
- journal article
- Language
- en
- Open access
- green
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- Nagueh, S. F., Bachinski, L. L., Meyer, D., Hill, R., Zoghbi, W. A., Tam, J. W., Quiñones, M. A., Roberts, R., & Marian, A. J. (2001). Tissue Doppler Imaging Consistently Detects Myocardial Abnormalities in Patients With Hypertrophic Cardiomyopathy and Provides a Novel Means for an Early Diagnosis Before and Independently of Hypertrophy. Circulation. https://doi.org/10.1161/01.cir.104.2.128
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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