Heart Rate after Cardiac Transplantation
Open accessAbstract
Two patients who have undergone heart transplantation 7 and 15 months previously were studied to determine basal heart rate, the effects of exercise, and acute changes in venous return and blood pressure as well as of vagal stimulation. In one case the effects of body temperature, isoprenaline (isoproterenol), beta blockade, and atropinization on heart rate were studied. Mean resting heart rates of 110 and 90, respectively, were observed in the two cases without any significant change with time since the surgical implantation. Sinus arrhythmia was not observed and heart rate was found to increase with exercise following isoprenaline infusion and following increase in body temperature. A decrease was observed after beta blockade, but no significant direct or baroreceptor reflex effects could be produced by changes in venous return, systemic blood pressure, vagal stimulation, and atropinization. Both patients are thus effectively denervated, and there is no evidence of reinnervation to date.
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Chemical and surgical denervation unmask the intrinsic rate of the sinus node, resulting in an increase in the resting heart rate to around 90 bpm and above.
“Chemical and surgical denervation unmask the intrinsic rate of the sinus node, resulting in an increase in the resting heart rate to around 90 bpm and above 16–19.”
From Sinus Tachycardia: a Multidisciplinary Expert Focused Review (2022) · cites this paper as [16]
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Cites
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- Authors
- BECK, W., BARNARD, C. N., & SCHRIRE, V.
- Affiliations
- University of Cape Town (ZA)
- Venue
- Circulation
- Published
- 1969-10
- Volume
- 40
- Issue
- 4
- Pages
- 437-445
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2039340624
- Cited by
- 81
- References
- 16
- Citations by year
- 2025: 1 · 2022: 1 · 2018: 2 · 2015: 1 · 2013: 1
- FWCI
- 5.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Council of Scientific and Industrial Research, India
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- heart transplantation, heart rate, resting heart rate, exercise response, isoproterenol, beta-adrenergic blockade, atropinization, vagus nerve stimulation, baroreflex, venous return, blood pressure, sinus arrhythmia, cardiac denervation, reinnervation, body temperature
- MeSH terms
- Aorta, Blood Pressure, Body Temperature, Cardiac Output, Central Venous Pressure, Physical Exertion, Heart Rate, Histocompatibility Testing, Humans, Male, Middle Aged, Oxygen Consumption, Propranolol, Respiration, Transplantation, Homologous, Heart Transplantation
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