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Hepatic Circulation in Cirrhosis of the Liver
Open accessAbstract
The hepatic blood flow (EHBF) was estimated by the bromsulfalein method in 39 cirrhotic patients. In 91 normal subjects hepatic blood flow averaged 1530 ml. per minute, and in the cirrhotics, hepatic blood flow averaged 1090 ml. per minute. In association with this highly significant reduction in blood flow, hepatic arteriovenous oxygen difference increased and bromsulfalein extraction fell. These findings indicate that hepatic blood flow tends to decrease more than oxidative metabolism of residual functional cells, so that relative ischemia and hypoxia of active liver tissue develop in cirrhotic disease.
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Citations
Cited by
THE CARDIAC OUTPUT AT REST IN LAENNEC'S CIRRHOSIS 1
Kowalski, H. J., & Abelmann, W. H. (1953) · Journal of Clinical Investigation · doi:10.1172/jci102813 · Cited by 586
Vorobioff, J., Bredfeldt, J. E., & Groszmann, R. J. (1983) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1983.244.1.g52 · Cited by 432
Differential Location and Distribution of Hepatic Immune Cells
Freitas-Lopes, M., Mafra, K., David, B., Carvalho-Gontijo, R., & Menezes, G. (2017) · Cells · doi:10.3390/cells6040048 · Cited by 126
Metadata
- Authors
- BRADLEY, S. E., INGELFINGER, F. J., & BRADLEY, G. P.
- Venue
- Circulation
- Published
- 1952-03
- Volume
- 5
- Issue
- 3
- Pages
- 419-429
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2022315878
- Cited by
- 166
- References
- 0
- FWCI
- 12.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Hepatic Circulation in Cirrhosis of the Liver. https://app.cochat.ai/papers/10.1161/01.cir.5.3.419
- The paper
- BRADLEY, S. E., INGELFINGER, F. J., & BRADLEY, G. P. (1952). Hepatic Circulation in Cirrhosis of the Liver. Circulation. https://doi.org/10.1161/01.cir.5.3.419
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
