The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study.
Open accessAbstract
The relationship between the degree of obesity and the incidence of cardiovascular disease (CVD) was reexamined in the 5209 men and women of the original Framingham cohort. Recent observations of disease occurrence over 26 years indicate that obesity, measured by Metropolitan Relative Weight, was a significant independent predictor of CVD, particularly among women. Multiple logistic regression analyses showed that Metropolitan Relative Weight, or percentage of desirable weight, on initial examination predicted 26-year incidence of coronary disease (both angina and coronary disease other than angina), coronary death and congestive heart failure in men independent of age, cholesterol, systolic blood pressure, cigarettes, left ventricular hypertrophy and glucose intolerance. Relative weight in women was also positively and independently associated with coronary disease, stroke, congestive failure, and coronary and CVD death. These data further show that weight gain after the young adult years conveyed an increased risk of CVD in both sexes that could not be attributed either to the initial weight or the levels of the risk factors that may have resulted from weight gain. Intervention in obesity, in addition to the well established risk factors, appears to be an advisable goal in the primary prevention of CVD.
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“Overweight and obesity are independently associated with an increased risk of cardiovascular events, even after the influence of metabolic cardiovascular risk factors linked to excess weight has been accounted for. 3-6”
From Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes (2023) · cites this paper as [4]
In the citing paper
“The PAR for heart failure due to obesity was 14% in women, and 11% in men, higher than that observed for diabetes mellitus, valvular heart disease, or left ventricular hypertrophy.”
From The Framingham Heart Study and the epidemiology of cardiovascular disease: a historical perspective (2014) · cites this paper as [78]
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“A paper by Kenchaiah and colleagues in 2002 using updated Framingham data arrived at similar conclusions.78”
From The Framingham Heart Study and the epidemiology of cardiovascular disease: a historical perspective (2014) · cites this paper as [78]
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Citations
Cites
Obesity and lipoprotein cholesterol in the Framingham offspring study
Garrison, R. J., Wilson, P. W. F., Castelli, W. P., Feinleib, M., Kannel, W. B., & Pm, M. (1980) · Metabolism · doi:10.1016/0026-0495(80)90216-4 · Cited by 150
Self-citationFabsitz, R. R., Feinleib, M., & Hrubec, Z. (1980) · Acta geneticae medicae et gemellologiae · doi:10.1017/s0001566000007789 · Cited by 22
Self-citationCORONARY-ARTERY DISEASE AND OBESITY
Sanders, K. (1959) · The Lancet · doi:10.1016/s0140-6736(59)90419-2 · Cited by 20
Flagged first, then by citations
Research works printed but not linked: 4
- [7]7. Chiang BN, Perlman LV, Epstein FH: Overweight and hyperten- sion. A review. Circulation 39: 403, 1969
- [15]15. Kannel WB, Gordon T: Obesity and cardiovascular disease. The Framingham Study. In Obesity Symposium. Proceedings of a Ser- vier Research Institute Symposium, edited by Burland WL, Sam- uel PD, Yudkin J. Edinburgh, Churchill-Livingstone, 1974, p 24
- [18]18. Garrison RJ, Feinleib M, Castelli WP, McNamara PM: Cigarette smoking as a confounder of the relationship between relative weight and long-term mortality in the Framingham Heart Study. JAMA. In press
- [26]26. Waldron I: Sex differences in longevity. In Second Conference on
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Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Whelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., et al. (2018) · Hypertension · doi:10.1161/hyp.0000000000000065 · Cited by 7,391
Kopelman, P. G. (2000) · Nature · doi:10.1038/35007508 · Cited by 4,795
Effects of Bariatric Surgery on Mortality in Swedish Obese Subjects
Sjöström, L., Narbro, K., Sjöström, C. D., Karason, K., Larsson, B., Wedel, H., Lystig, T., Sullivan, M., Bouchard, C., Carlsson, B., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa066254 · Cited by 4,668
Obesity and cardiovascular disease: a scientific statement from the American Heart Association
Powell-Wiley, T. M., Poirier, P., Burke, L. E., Després, J.-P., Gordon-Larsen, P., Lavie, C. J., Lear, S. A., Ndumele, C. E., Neeland, I. J., Sanders, P., et al. (2021) · Circulation · doi:10.1161/cir.0000000000000973 · Cited by 3,691
Metadata
- Authors
- Hubert, H. B., Feinleib, M., McNamara, P. M., & Castelli, W. P.
- Affiliations
- National Institutes of Health (US)
- Venue
- Circulation
- Published
- 1983-05
- Volume
- 67
- Issue
- 5
- Pages
- 968-977
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2110713453
- Cited by
- 4,241
- References
- 3
- Citations by year
- 2026: 35 · 2025: 67 · 2024: 88 · 2023: 93 · 2022: 107 · 2021: 153 · 2020: 140 · 2019: 141 · 2018: 163 · 2017: 153 · 2016: 183 · 2015: 182 · 2014: 181 · 2013: 165 · 2012: 168
- FWCI
- 31.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- obesity, cardiovascular disease, Framingham Heart Study, coronary artery disease, coronary death, congestive heart failure, stroke, sex differences, weight gain, primary prevention, risk factors
- MeSH terms
- Adult, Aged, Blood Pressure, Body Weight, Cardiovascular Diseases, Cholesterol, Coronary Disease, Female, Follow-Up Studies, Glucose Tolerance Test, Cardiomegaly, Humans, Male, Massachusetts, Middle Aged, Obesity, Regression Analysis, Risk, Sex Factors, Smoking
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