The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Adenosine: electrophysiologic effects and therapeutic use for terminating paroxysmal supraventricular tachycardia.
Abstract
Adenosine was administered intravenously to 17 patients undergoing intracardiac electrophysiologic studies. At a mean dose of 179 +/- 88 micrograms/kg (+/- SD), adenosine suppressed sinus node automaticity and depressed atrioventricular (AV) nodal conduction. These effects were less than 20 sec in duration and were not influenced by muscarinic blockade with atropine (0.02 to 0.03 mg/kg). Adenosine at this dose had no effect on antegrade conduction over accessory pathways in patients with Wolff-Parkinson-White syndrome. No independent hemodynamic effects were observed. In six patients, adenosine was administered intravenously during stimulation-induced paroxysmal supraventricular tachycardia. In the five patients in whom the reentry loop of their tachycardia included the AV node, adenosine at a mean dose of 83 +/- 35 micrograms/kg (+/- SD) terminated their tachycardia within 20 sec after peripheral intravenous injection. The dose of adenosine required to terminate these tachycardias did not produce manifest sinus node suppression, and sinus rhythm promptly resumed in all patients. Adenosine did not terminate either supraventricular tachycardia due to intra-atrial reentry or atrial flutter, but did produce transient AV block during these arrhythmias. Our findings demonstrate that the human sinus and AV nodes are sensitive to physiologic doses of adenosine and that adenosine may be used safely and effectively to terminate acute episodes of supraventricular tachycardia that involve the AV node in the reentry pathway.
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Citations
Cites
Comparative pharmacology of calcium antagonists: Nifedipine, verapamil and diltiazem
Henry, P. D. (1980) · The American Journal of Cardiology · doi:10.1016/0002-9149(80)90366-5 · Cited by 843
The control of the metabolism and the hormonal role of adenosine.
Arch, J. R. S., & Newsholme, E. A. (1978) · PubMed · Cited by 415
Intracardiac Electrophysiologic Techniques in Recurrent Syncope of Unknown Cause
DiMARCO, J. P., GARAN, H., HARTHORNE, J. W., & RUSKIN, J. N. (1981) · Annals of Internal Medicine · doi:10.7326/0003-4819-95-5-542 · Cited by 216
Self-citationBelardinelli, L., Fenton, R. A., West, A., Linden, J. M., Althaus, J. S., & Berne, R. M. (1982) · Circulation Research · doi:10.1161/01.res.51.5.569 · Cited by 141
Self-citationGreco, R., Musto, B., Arienzo, V., Alborino, A., Garofalo, S., & Marsico, F. (1982) · Circulation · doi:10.1161/01.cir.66.3.504 · Cited by 97
The Action of Adenosine Upon the Human Heart
Honey, R. M., Ritchie, W. T., & Thomson, W. A. (1930) · QJM · doi:10.1093/qjmed/os-23.92.485 · Cited by 91
Chronotropic and Dromotropic Effects of Adenosine
Belardinelli, L., West, A., Crampton, R. S., & Berne, R. M. (1983) · Springer eBooks · doi:10.1007/978-1-4613-3909-0_24 · Cited by 63
Self-citationActions of adenosine on normal and abnormal impulse initiation in canine ventricle
Rosen, M. R., Danilo, P., & Weiss, R. M. (1983) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1983.244.5.h715 · Cited by 43
Antiadrenergic action of adenosine on ventricular myocardium in embryonic chick hearts
Belardinelli, L. (1982) · Journal of Molecular and Cellular Cardiology · doi:10.1016/0022-2828(82)90207-3 · Cited by 42
Self-citationSustained intra‐atrial reentrant tachycardia. Electrophysiologic study of 20 cases
Coumel, P., FLAMMANG, D., ATTUEL, P., & Leclercq, J. ‐. (1979) · Clinical Cardiology · doi:10.1002/clc.4960020301 · Cited by 34
Cited by
Lerman, B. B., Belardinelli, L., West, G. A., Berne, R. M., & DiMarco, J. P. (1986) · Circulation · doi:10.1161/01.cir.74.2.270 · Cited by 473
Self-citationDiMarco, J. P., Miles, W., Akhtar, M., Milstein, S., Sharma, A. D., Platia, E., McGovern, B., Scheinman, M. M., & Govier, W. C. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-2-104 · Cited by 306
Matching coronary blood flow to myocardial oxygen consumption
Tune, J. D., Gorman, M. W., & Feigl, E. O. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01345.2003 · Cited by 306
Adenosine and Supraventricular Tachycardia
Camm, A. J., & Garratt, C. J. (1991) · New England Journal of Medicine · doi:10.1056/nejm199112053252306 · Cited by 261
Alboni, P., Menozzi, C., Brignole, M., Paparella, N., Gaggioli, G., Lolli, G., & Cappato, R. (1997) · Circulation · doi:10.1161/01.cir.96.1.260 · Cited by 166
Metadata
- Authors
- DiMarco, J. P., Sellers, T. D., Berne, R. M., West, G. A., & Belardinelli, L.
- Venue
- Circulation
- Published
- 1983-12
- Volume
- 68
- Issue
- 6
- Pages
- 1254-1263
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2038607970
- Cited by
- 366
- References
- 10
- FWCI
- 12.76
- Type
- journal article
- Language
- en
- Open access
- closed
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- DiMarco, J. P., Sellers, T. D., Berne, R. M., West, G. A., & Belardinelli, L. (1983). Adenosine: electrophysiologic effects and therapeutic use for terminating paroxysmal supraventricular tachycardia. Circulation. https://doi.org/10.1161/01.cir.68.6.1254
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