The DOI matches its Crossref record; 155 of the 155 references it cites were found in a registry or an index.
Matching coronary blood flow to myocardial oxygen consumption
Abstract
At rest the myocardium extracts ∼75% of the oxygen delivered by coronary blood flow. Thus there is little extraction reserve when myocardial oxygen consumption is augmented severalfold during exercise. There are local metabolic feedback and sympathetic feedforward control mechanisms that match coronary blood flow to myocardial oxygen consumption. Despite intensive research the local feedback control mechanism remains unknown. Physiological local metabolic control is not due to adenosine, ATP-dependent K+channels, nitric oxide, prostaglandins, or inhibition of endothelin. Adenosine and ATP-dependent K+channels are involved in pathophysiological ischemic or hypoxic coronary dilation and myocardial protection during ischemia. Sympathetic β-adrenoceptor-mediated feedforward arteriolar vasodilation contributes ∼25% of the increase in coronary blood flow during exercise. Sympathetic α-adrenoceptor-mediated vasoconstriction in medium and large coronary arteries during exercise helps maintain blood flow to the vulnerable subendocardium when cardiac contractility, heart rate, and myocardial oxygen consumption are high. In conclusion, several potential mediators of local metabolic control of the coronary circulation have been evaluated without success. More research is needed.
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Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525
A novel potent vasoconstrictor peptide produced by vascular endothelial cells
Yanagisawa, M., Kurihara, H., Kimura, S., Tomobe, Y., Kobayashi, M., Mitsui, Y., Yazaki, Y., Goto, K., & Masaki, T. (1988) · Nature · doi:10.1038/332411a0 · Cited by 10,729
ATP-regulated K+ channels in cardiac muscle
Noma, A. (1983) · Nature · doi:10.1038/305147a0 · Cited by 2,328
Liu, G. S., Thornton, J., Van Winkle, D. M., Stanley, A. W., Olsson, R. A., & Downey, J. M. (1991) · Circulation · doi:10.1161/01.cir.84.1.350 · Cited by 1,351
Identification of Epoxyeicosatrienoic Acids as Endothelium-Derived Hyperpolarizing Factors
Campbell, W. B., Gebremedhin, D., Pratt, P. F., & Harder, D. R. (1996) · Circulation Research · doi:10.1161/01.res.78.3.415 · Cited by 1,221
Intracellular ATP directly blocks K+ channels in pancreatic B-cells
Cook, D. L., & Hales, N. (1984) · Nature · doi:10.1038/311271a0 · Cited by 1,208 · cited 1×
“These channels are present in a variety of tissues including vascular smooth muscle, arterial endothelial cells, cardiac muscle, skeletal muscle, brain, and pancreatic -cells (9, 35, 107, 144, 153, 158, 182).”
BackgroundHyperpolarizing Vasodilators Activate ATP-sensitive K + Channels in Arterial Smooth Muscle
Standen, N. B., Quayle, J. M., Davies, N. W., Brayden, J. E., Huang, Y., & Nelson, M. T. (1989) · Science · doi:10.1126/science.2501869 · Cited by 1,190
Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow
Berne, R. M. (1963) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1963.204.2.317 · Cited by 1,012
Cytochrome P450 2C is an EDHF synthase in coronary arteries
Fisslthaler, B., Popp, R., Kiss, L., Potente, M., Harder, D. R., Fleming, I., & Busse, R. (1999) · Nature · doi:10.1038/46816 · Cited by 911
The role of adenosine in the regulation of coronary blood flow.
Berne, R. M. (1980) · Circulation Research · doi:10.1161/01.res.47.6.807 · Cited by 875
Cited by
Effect of exercise training on endothelium‐derived nitric oxide function in humans
Green, D. J., Maiorana, A., O'Driscoll, G., & Taylor, R. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.068197 · Cited by 1,040
Regulation of coronary blood flow during exercise
Duncker, D. J., & Bache, R. J. (2008) · Physiological Reviews · doi:10.1152/physrev.00045.2006 · Cited by 936
Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control
Huang, Z. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24650 · Cited by 520
Gladwin, M. T., Raat, N. J. H., Shiva, S., Dezfulian, C., Hogg, N., Kim-Shapiro, D. B., & Patel, R. P. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00407.2006 · Cited by 329
The functional nitrite reductase activity of the heme-globins
Gladwin, M. T., & Kim-Shapiro, D. B. (2008) · Blood · doi:10.1182/blood-2008-01-115261 · Cited by 293
Metadata
- Authors
- Tune, J. D., Gorman, M. W., & Feigl, E. O.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2004-07
- Volume
- 97
- Issue
- 1
- Pages
- 404-415
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2061112342
- Cited by
- 306
- References
- 155
- FWCI
- 43.59
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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