The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Free radicals and myocardial injury: pharmacologic implications.
Open accessAbstract
A GROWING NUMBER of articles purport to demon- strate the importance of oxygen free radicals in a variety of pathophysiologic processes, including injury due to radiation, inflammation, and oxygen toxicity.The purpose of this essay is to examine the hypothesis that activated oxygen species may play a role in the extension of myocardial injury due to ischemia fol- lowed by reperfusion.Activated oxygen species include-superoxide anion, hydrogen peroxide, and hydroxyl radical.By virtue of an unpaired electron, they react with virtually all cell components, especially the sulfhydryl-containing ami- no acids and the unsaturated fatty acids.The potential consequences of unimpeded free-radical reactions in- clude denaturation of proteins, peroxidation of mem- brane lipids, generation of chemotactic factors, and impairment of collagen synthesis.As a result, there may be a loss of enzyme activity, disturbed membrane permeability, and increased inflammatory cell infiltra- tion.The intracellular defenses against oxygen radi- cal-mediated tissue damage include superoxide dis- mutase (SOD), an enzyme that catalyzes dismutation of superoxide anion to hydrogen peroxide.Two addi- tional cytoplasmic enzymes, catalase (CAT) and glutathione peroxidase, degrade hydrogen peroxide to water and oxygen.
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Citations
Cites
Myocardial reperfusion: a double-edged sword?
Braunwald, E., & Kloner, R. A. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112160 · Cited by 1,367
Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog.
Romson, J. L., Hook, B. G., Kunkel, S. L., Abrams, G. D., Schork, M. A., & Lucchesi, B. R. (1983) · Circulation · doi:10.1161/01.cir.67.5.1016 · Cited by 1,164
Self-citationOxygen free radicals in ischemic acute renal failure in the rat.
Paller, M. S., Hoidal, J. R., & Ferris, T. F. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111524 · Cited by 1,058
Jolly, S. R., Kane, W. J., Bailie, M. B., Abrams, G. D., & Lucchesi, B. R. (1984) · Circulation Research · doi:10.1161/01.res.54.3.277 · Cited by 900
Self-citationLeukocyte capillary plugging in myocardial ischemia and reperfusion in the dog.
Engler, R. L., Schmid‐Schönbein, G. W., & Pavelec, R. S. (1983) · PubMed Central · Cited by 855
Xanthine oxidase as a source of free radical damage in myocardial ischemia
CHAMBERS, D., PARKS, D., PATTERSON, G., ROY, R., MCCORD, J., YOSHIDA, S., PARMLEY, L., & DOWNEY, J. (1985) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(85)80017-1 · Cited by 672
Role of oxygen in the cellular damage induced by re-oxygenation of hypoxic heart
Guarnieri, C. (1980) · Journal of Molecular and Cellular Cardiology · doi:10.1016/0022-2828(80)90081-4 · Cited by 537
Mullane, K. M., Read, N., Salmon, J. A., & Moncada, S. (1984) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21794-3 · Cited by 471
Korthuis, R. J., Granger, D. N., Townsley, M. I., & Taylor, A. E. (1985) · Circulation Research · doi:10.1161/01.res.57.4.599 · Cited by 410
Myers, M. L., Bolli, R., Lekich, R. F., Hartley, C. J., & Roberts, R. (1985) · Circulation · doi:10.1161/01.cir.72.4.915 · Cited by 323
Cited by
Oates, J. A., Wood, A. J. J., & Hirsh, J. (1991) · New England Journal of Medicine · doi:10.1056/nejm199105303242206 · Cited by 830
Yet, S.-F., Tian, R., Layne, M. D., Wang, Z. Y., Maemura, K., Solovyeva, M., Ith, B., Melo, L. G., Zhang, L., Ingwall, J. S., et al. (2001) · Circulation Research · doi:10.1161/hh1401.093314 · Cited by 420
Metadata
- Authors
- Werns, S. W., Shea, M. J., & Lucchesi, B. R.
- Venue
- Circulation
- Published
- 1986-07
- Volume
- 74
- Issue
- 1
- Pages
- 1-5
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2060933702
- Cited by
- 295
- References
- 19
- FWCI
- 33.40
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Werns, S. W., Shea, M. J., & Lucchesi, B. R. (1986). Free radicals and myocardial injury: pharmacologic implications. Circulation. https://doi.org/10.1161/01.cir.74.1.1
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
