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Cited by 347

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Clinical application of atrial natriuretic polypeptide in patients with congestive heart failure: beneficial effects on left ventricular function.

Open access
Saito, Y, Nakao, K, Nishimura, K, Sugawara, A, Okumura, K, Obata, K, Sonoda, R, Ban, T, Yasue, H, Imura, H·1987·Circulation

Abstract

Synthetic alpha-human atrial natriuretic polypeptide was infused in patients with congestive heart failure (CHF) (New York Heart Association class III or IV) and in those without CHF. The infusion of atrial natriuretic polypeptide (ANP) at a rate of 0.1 microgram/kg/min significantly decreased pulmonary capillary wedge pressure and increased stroke volume index in all of the patients with CHF, whereas it decreased pulmonary capillary wedge pressure but caused no significant change in stroke volume index in the patients without CHF. Concomitant significant reductions in total systemic resistance were observed in both groups of patients. The ANP infusion significantly increased the urine volume, the excretion of sodium, and endogenous creatinine clearance in the patients without CHF. In the patients with CHF, it also showed a tendency to increase all these variables, but the urine volume did not correlate with the reduction in pulmonary capillary wedge pressure. The ANP infusion also decreased plasma aldosterone concentrations in these patients, although no significant difference was observed in the decrement of the plasma aldosterone concentration in the patients with and those without CHF. These findings indicate that the ANP infusion improves left ventricular function in patients with CHF, and suggest that this improvement results mainly from the vasodilating activity of ANP.

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Crossref · 10.1161/01.cir.76.1.115

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Metadata

Authors
Saito, Y., Nakao, K., Nishimura, K., Sugawara, A., Okumura, K., Obata, K., Sonoda, R., Ban, T., Yasue, H., & Imura, H.
Venue
Circulation
Published
1987-07
Volume
76
Issue
1
Pages
115-124
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
OpenAlex
W2056851052
Cited by
347
References
39
FWCI
17.49
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Clinical application of atrial natriuretic polypeptide in patients with congestive heart failure: beneficial effects on left ventricular function. https://app.cochat.ai/papers/10.1161/01.cir.76.1.115
The paper
Saito, Y., Nakao, K., Nishimura, K., Sugawara, A., Okumura, K., Obata, K., Sonoda, R., Ban, T., Yasue, H., & Imura, H. (1987). Clinical application of atrial natriuretic polypeptide in patients with congestive heart failure: beneficial effects on left ventricular function. Circulation. https://doi.org/10.1161/01.cir.76.1.115

Data sources

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.